Xiamen Sinopeg Biotech Co., Ltd.

Xiamen Sinopeg Biotech Co., Ltd. SINOPEG is a dynamic science company with professional R&D, Manufacturing and Sales capability.

The company is mainly engaged in drug delivery system (DDS) and new medical materials business.

🔥 TIDES USA 2026 is in full swing! 🔥Our colleagues Candice Zheng and XiaBo LIU from SINOPEG are already at Booth  #1010,...
13/05/2026

🔥 TIDES USA 2026 is in full swing! 🔥

Our colleagues Candice Zheng and XiaBo LIU from SINOPEG are already at Booth #1010, ready to connect with you! 👋🤝

If you're attending the event and would like to explore collaborations, discuss the latest innovations in DDS, or simply have a great conversation — don't hesitate to stop by Booth #1010! 📍

Let's make the most of this amazing gathering. See you there! 👀✨

Accelerate Radiopharmaceutical R&D with a Complete Precursor Building Block Platform 🧬⚛️At Sinopeg, we’re dedicated to e...
11/05/2026

Accelerate Radiopharmaceutical R&D with a Complete Precursor Building Block Platform 🧬⚛️

At Sinopeg, we’re dedicated to empowering radiopharmaceutical innovators with a comprehensive library of precursor building blocks covering all three core modules of radiopharmaceutical molecules:

🔹 Ligand (small molecules, peptides, antibodies) – for precise targeting
🔹 Linker (PEG, heterocycles, short peptides) – connecting ligand & chelator
🔹 Chelator (DOTA, DOTAGA, NOTA, PSC, etc.) – for stable radionuclide chelation

✅ GMP-grade building blocks – independently controlled
✅ Modular synthesis platform – individual or custom combinations available
✅ Tailored solutions – to significantly accelerate your early-stage R&D

Our experienced synthesis team ensures high purity and stability, e.g.:
Monodisperse PEG homolog impurities ≤0.2%, single impurity ≤1%

🔥 What truly sets us apart –
We’ve achieved stable, large-scale supply of critical precursors, backed by a robust quality research system and impurity identification/control capabilities. We provide complete cold kit services for IND filing, supporting dual filing in China and the U.S. and other global regulatory submissions.

🔄 End-to-end radiopharmaceutical precursor enablement –
From molecular design, CMC, clinical supply to commercial production – we cover the full lifecycle, leveraging precursors to boost the efficiency of hot drug development.

⏳ What makes radiopharmaceutical R&D faster?
A deep respect for both time and quality.

As one of the few CDMOs in China solely focused on radiopharmaceutical precursors, our expertise is concentrated and our services are specialized. We look forward to partnering with you!

📩 Contact us:
WeChat / Phone: +86 18050049791
Email: [email protected]

🧬 Unlocking the Next Generation of Precision Drug Delivery with DMG-pSar25In the rapidly evolving world of nanomedicine,...
09/05/2026

🧬 Unlocking the Next Generation of Precision Drug Delivery with DMG-pSar25

In the rapidly evolving world of nanomedicine, “precision drug delivery” is no longer just a vision—it’s becoming reality. And at the heart of this breakthrough lie high-performance nanocarriers.

🔬 Enter DMG-pSar25 – a next-gen polymer that’s redefining what’s possible in targeted delivery. Its secret? A smart “anchor + shield” design:

🔹 DMG (hydrophobic anchor) – firmly embeds into lipid bilayers, ensuring structural stability.
🔹 pSar25 (hydrophilic polysarcosine shell) – forms a robust hydration layer, providing excellent antifouling properties and biocompatibility while evading immune clearance.

🧪 This unique structure makes DMG-pSar25 an ideal building block for advanced LNPs and liposomes.

🚀 Why Polysarcosine? The PEG Alternative You’ve Been Waiting For

PEG lipids have long been the gold standard for prolonging circulation time—but their limitations are hard to ignore:
⚠️ Anti-PEG antibodies
⚠️ Hypersensitivity reactions
⚠️ Accelerated blood clearance (ABC phenomenon)

🧬 Polysarcosine (pSar) – a poly-peptide based on endogenous sarcosine – offers a compelling upgrade:
✅ Biodegradable
✅ Non-toxic
✅ Minimal immunogenicity
✅ Suppresses ABC induction even after repeated dosing

That’s a game-changer for chronic disease treatments like cancer or inflammatory disorders.

🎯 Beyond Replacement: Targeted Delivery Potential

By functionalizing the end group of DMG-pSar25, we can covalently attach targeting ligands – enabling precise cell/tissue recognition, reducing off-target effects, and improving therapeutic outcomes.

👉 At Sinopeg, we don’t just supply high-purity polysarcosine – we also offer customization services to accelerate your nanocarrier development.

💡 Emerging Applications

🔹 mRNA delivery – protecting nucleic acids from enzymatic degradation
🔹 Targeted therapy – reducing chemotherapy side effects
🔹 Immunotherapy & regenerative medicine – opening new frontiers

📌 Conclusion

DMG-pSar25 combines structural elegance, low immunogenicity, and targeting potential – making it a powerful candidate for next-gen precision medicine.

Whether you need PEG derivatives or polysarcosine-based solutions, Sinopeg provides integrated, quality-controlled platforms for every R&D need.

Let’s shape the future of nanomedicine together. 💊🧬

🚀 TIDES USA 2026 is almost here!We’re excited to announce that Sinopeg will be exhibiting at Booth  #1010 – and our coll...
07/05/2026

🚀 TIDES USA 2026 is almost here!

We’re excited to announce that Sinopeg will be exhibiting at Booth #1010 – and our colleagues Yaping Zheng and Xiaobo Liu can’t wait to meet you in person! 🙌

📍 Venue: Hynes Convention Center, Boston
📅 Date: May 11–14, 2026

Whether you’re an old friend or a new connection, please stop by Booth 1010 to chat about oligonucleotides, peptides, mRNA, and the latest innovations in PEGylation technology. Let’s explore new possibilities together! 🔬✨

See you in Boston! 👋

https://www.sinopeg.com/join-us-at-tides-usa-2026-in-hynes-convention-center-booth-1010_n260

Excited to share that SINOPEG is now offering high-purity Retatrutide side chains to support the next generation of meta...
28/04/2026

Excited to share that SINOPEG is now offering high-purity Retatrutide side chains to support the next generation of metabolic therapeutics. 💊✨

As the demand for innovative peptide-based treatments continues to grow, purity and consistency in critical intermediates are more important than ever. Our team at SINOPEG ensures:

✅ Rigorously tested purity profiles
✅ Reliable scalability for R&D and commercial needs
✅ Stringent quality control standards

Whether you're advancing preclinical programs or optimizing GMP manufacturing — we're here to help.

📞 Call or message us today to request technical data or discuss your project requirements.

Let’s accelerate peptide innovation together. 🚀

🔬 Unlocking Next-Generation Diabetes Therapies with SINOPEGWe are proud to introduce SINOPEG – your trusted partner in t...
23/04/2026

🔬 Unlocking Next-Generation Diabetes Therapies with SINOPEG

We are proud to introduce SINOPEG – your trusted partner in the development of advanced fatty acid-modified side chains 💊

As GLP-1 analogs (e.g., semaglutide, liraglutide) revolutionize diabetes and obesity treatment, the critical role of high-purity fatty acid side chain intermediates cannot be overstated. These modifications drive:
✅ Extended half-life
✅ Improved albumin binding
✅ Enhanced patient compliance with once-weekly dosing

✨ SINOPEG specializes in the design and scale-up of lipophilic side chains, including C22, C20, C18, and custom fatty acid derivatives, meeting the rigorous demands of anti-diabetic drug development.

🔑 Why choose SINOPEG?

🌟 GMP-grade manufacturing

📄 Full regulatory support (DMF ready)

⚡ Agile scale-up from R&D to commercial supply

📩 Let’s accelerate your GLP-1 pipeline together. Contact us today: https://www.sinopeg.com/intermediate-of-anti-diabetic-drug_c3

🔬 Next-generation ADC linkers: when glycochemistry meets precision oncologyGlycan-based linkers are emerging as a powerf...
22/04/2026

🔬 Next-generation ADC linkers: when glycochemistry meets precision oncology

Glycan-based linkers are emerging as a powerful tool in antibody-drug conjugate (ADC) design, offering a unique combination of high hydrophilicity, biocompatibility, and tumor-specific payload release.

Unlike conventional linkers, these sugar derivatives leverage tumor-overexpressed glycosidases (e.g., β-glucuronidase, β-galactosidase) to enable selective cleavage inside cancer cells, minimizing off-target toxicity while improving solubility.

Two major design strategies stand out:

1️⃣ Aminosugar-modified linkers (non-cleavable) – e.g., glucosamine, cyclodextrin. They enhance water solubility and allow higher drug-loading ratios without aggregation.

2️⃣ Glycosidase-cleavable linkers – designed for precise intratumoral release. The β-glucuronide linker, in particular, shows excellent stability in circulation and efficient cleavage in the lysosomal environment of tumor cells.

🔓 Emerging motifs like α-L-iduronide and OHPAS scaffolds further push the boundaries of cleavage efficiency and hydrophilicity, opening new avenues for solid tumor targeting.

This “hydrophilic + cleavable” dual-advantage linker class represents a smart solution for next-gen ADCs with a wider therapeutic window.

💡 What's your take on glycan-based linkers – a niche tool or the new standard in ADC design?

Reference:

Fu Q , Kong X , Liu Y ,et al.The role of hydrophilic linkers in next-generation antibody-drug conjugates[J].Journal of Controlled Release, 2026, 391(c):114612.DOI:10.1016/j.jconrel.2026.114612

Unlocking the clinical potential of nanomedicines starts with smarter materials. 🧬🔬The clinical performance of nano-drug...
17/04/2026

Unlocking the clinical potential of nanomedicines starts with smarter materials. 🧬🔬

The clinical performance of nano-drug delivery systems heavily depends on the physicochemical properties and in vivo behavior of carrier materials. The new generation of materials must combine stealth effect, structural uniformity, and biodegradability.

Enter monodisperse polysarcosine (pSar) – an ideal candidate meeting all these demands. ✨

🧬 Superior stealth effect
pSar consists of N-methyl glycine repeats, no chiral centers, and no hydrogen bond donors for protein binding. This creates an exceptionally stable hydration layer, effectively preventing opsonin adsorption and minimizing protein corona formation. The result? ✅ Prolonged circulation half-life ✅ Reduced immune clearance ✅ Avoidance of the accelerated blood clearance (ABC) phenomenon – making pSar-decorated nanocarriers more reliable for in vivo applications.

📐 Uniform structure for reproducibility
Monodisperse pSar features highly consistent chain lengths, enabling the formation of uniform micelles and vesicles with stable drug loading. This ensures excellent batch-to-batch reproducibility and predictable pharmacokinetics – a solid foundation for clinical translation.

🌱 Biocompatible & biodegradable
pSar is enzymatically degraded in vivo into naturally occurring sarcosine – non-toxic and easily excreted without long-term accumulation. Multiple studies confirm that pSar-based antibody-drug conjugates and nanomedicines achieve potent anti-tumor efficacy together with outstanding safety profiles.

🎯 The road ahead
As research advances, monodisperse polysarcosine is poised to play a pivotal role in tumor-targeted therapy and precision drug delivery – driving nanomedicine toward greater efficacy and safety.

What are your thoughts on next-generation stealth materials? Let’s discuss in the comments! 👇

🎉 Only one month to go until TIDES USA 2026 – the premier event for oligonucleotides and peptides innovation!SINOPEG is ...
16/04/2026

🎉 Only one month to go until TIDES USA 2026 – the premier event for oligonucleotides and peptides innovation!
SINOPEG is thrilled to join this year's gathering. Come meet us in person at Booth #1010 to explore how our advanced DDS solutions can power your next-generation therapeutics.
📅 Date: May 11-14, 2026
📍 Location: Hynes Convention Center
🎟️ Exclusive offer for our community:
Save 10% on your registration with VIP Code 👉 SPONSOR10 (apply at checkout).
We look forward to connecting, sharing insights, and building new partnerships. Let’s make TIDES 2026 a milestone event together!

Is PEG losing its crown? 👑 Meet poly(sarcosine) – a low-immunity alternative for repeat dosing. 🧬For decades, poly(ethyl...
10/04/2026

Is PEG losing its crown? 👑 Meet poly(sarcosine) – a low-immunity alternative for repeat dosing. 🧬

For decades, poly(ethylene glycol) (PEG) has been the gold standard "stealth coat" in drug delivery. 🥇
But repeated administration comes with a hidden cost: anti-PEG antibodies. ⚠️

These antibodies trigger accelerated blood clearance (ABC) – reducing efficacy and raising the risk of hypersensitivity. A real challenge for chronic or multi-dose therapies. 🔁💉

So what’s the alternative that stays invisible, dose after dose?
✨ Poly(sarcosine) (pSar). ✨

pSar is a polypeptide-like polymer with excellent biocompatibility and a flexible backbone. Unlike PEG, it barely triggers immune recognition. 🧪
In animal models of repeated dosing, pSar does not induce significant antibody responses or the ABC phenomenon. 🐭✅

The result? Long-circulating carriers that work – every single time. 💊🔁💪

Why is pSar so "low-profile"?
Its unique backbone structure and strong hydration capacity resist protein adsorption and evade immune attack. 🛡️💧
This makes it especially valuable for chronic diseases and nucleic acid delivery. 🧬🧠

Even better: pSar’s molecular weight, chain length, and end groups can be precisely tuned – from LNPs and hydrogels to mRNA adjuvants and long-acting injectables. 🎛️📦

Of course, this technology is still in the lab-to-clinic transition. Long-term safety and scalable manufacturing need further validation. 🔬🚧
But the potential is undeniable.

Poly(sarcosine) opens a promising path to overcome the repeat-dosing dilemma – without the immune baggage. 🧳🚫

What are your thoughts on moving beyond PEG? Let's discuss. 💬👇

Exciting news! Sinopeg’s DHA-1 series cationic lipids now granted US patent – completing our “Grand Slam” in China, Euro...
09/04/2026

Exciting news! Sinopeg’s DHA-1 series cationic lipids now granted US patent – completing our “Grand Slam” in China, Europe, and the US! 🇨🇳🇪🇺🇺🇸

Following the European patent authorization in February 2026, we are proud to announce that our US patent application (No. 18/269,728) for DHA-1, SNP24-1, SNP25-1, SNP26-1, and other cationic lipids has been officially approved by the USPTO – in Markush-style form.

Why Markush-style matters:
It protects not just individual compounds but the entire family of structures sharing the same core scaffold – offering broader coverage, stronger barriers against design-arounds, and greater peace of mind for our customers’ commercial programs.

Global IP & compliance leadership:

🇨🇳 China patent (2022)

🇪🇺 Europe patent (2026.02)

🇺🇸 US Markush patent (2026.04)

CDE pharmaceutical excipient filing (F20230000445) & FDA DMF (039452) already in place.

Beyond single compounds:
Our patent portfolio covers the full LNP delivery system – from lipids and compositions to liposomes, nucleic acid formulations, and applications.

One-stop LNP solutions – full component supply, globally protected.

📩 For more information on DHA-1 series and our LNP lipid portfolio, please contact us or visit https://www.sinopeg.com

Address

Jianye Building D, Torch Hi-Tech Industrial Development Zone, Xiang’an District
Xiamen
361000

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