Centre of Chemical Synthesis & Polymer Technology - CCSPT - IOS

The Centre of Chemical Synthesis & Polymer Technology (CCSPT) is a hub of innovation of three dynamic research groups: the Organic Synthesis Research Group, the Polymer Composites Research Group, and the Microbiology & Tissue Culture Research Group. Organic Synthesis Research Group

Organic Synthesis Research Group concentrates on creating and understanding new molecules, which will lead to the di

scovery of new or refined drugs as well as novel and potential organocatalysts. The research group focuses in the research area of organic chemistry namely development of synthetic methodology, in addition to structural exploration and synthetic studies of some nitrogen heterocycles with a pyrrolidine ring system such as proteasome inhibitor lactacystin, hypotensive drug codonopsinine, lipophilic neurotoxin janolusimide and angiogenesis inhibitor streptopyrrolidine. By means of 2,3- and 2,4-pyrrolidinedione intermediates, the group concentrates on synthesizing lactone-lactam and lactam-lactam bicyclic systems which are highly likely to be important precursors towards the development of pharmaceutical agents. A research on potential organocatalysts which revolves around not only environment-friendly catalysts but also pyrrolidinium type ionic liquids are also being explored based on previous knowledge of the chemical properties of the pyrrolidine ring moiety. The Organic Synthesis Research Group has assisted Sime Darby Research Sdn Bhd in developing derivatives of L-quebrachitol which include mannitol, inositol and inositol triphosphate, with potential confectionery and pharmaceutical values. Recently, it has secured a research grant under the Transdisciplinary Research Grant Scheme (TRGS) with the research teams from iPROMISE UiTM developing strategies in generating and investigating potential multi-target inhibitors with derivatives of chalcones and flavones for targets related to inflammation; this collaborative effort is therefore hoped to eventually develop leads in drug discovery. The Organic Synthesis Research Laboratory is equipped with Nuclear Magnetic Resonance Spectroscopy (NMR) and High Resolution Mass Spectroscopy (HRMS) and the group has continually exercised collaboration with other research teams within as well as outside the university and provides capacity building for potential organic chemists.