Laboratório de Genética Humana - UMa

Laboratório de Genética Humana - UMa Genética Forense (Testes de Paternidade)
Genética Clínica
Citogenética

O Laboratório de Genética Humana é uma unidade de investigação e prestação de serviço, criado pela Universidade da Madeira, em 2001, face à carência a nível regional de laboratórios especializados na realização de testes de DNA, na deteção de anomalias genéticas e na deteção de patologias genéticas diversas.

02/03/2025

Dietary fructose promotes tumor growth in animal models of melanoma, breast cancer, and cervical cancer.

02/03/2025

A new weapon against cancer cells has been discovered by scientists.

Despite being responsible for thousands of deaths annually due to food poisoning, the disease-causing bacterium salmonella might just be our unexpected ally in the fight against cancer.

Researchers have discovered that salmonella can be genetically modified to enhance the cancer-fighting abilities of T cells, a type of white blood cell crucial to the body's immune response. Previous attempts to utilize salmonella in cancer therapies have been hampered by its tendency to deplete asparagine, an amino acid essential for T cell activation.

This depletion inadvertently hinders the T cells' ability to effectively target and destroy cancer cells. However, this new research pinpoints the specific mechanism responsible for this immune suppression, offering a potential solution to unlock the full therapeutic potential of salmonella. By further engineering the bacteria to avoid attacking asparagine, scientists believe they can create a powerful ally in the fight against cancer.

This modified salmonella would not only target the tumor itself, but also empower the immune system to mount a more robust attack against cancer cells. This innovative approach has shown promising results in mice with bowel cancer, offering hope for more effective treatments for colorectal and potentially other cancers in the future. The next steps involve further research and development to translate these findings into safe and effective treatments for human patients, offering new hope in the ongoing battle against cancer.

learn more: https://news.cancerresearchuk.org/2025/01/23/fighting-fire-with-fire-could-salmonella-treat-bowel-cancer/ #:~:text=But%20things%20have%20changed.,mouse%20models%20of%20bowel%20cancer.

02/03/2025

Humanity came close to extinction 800,000 years ago. Only 1,280 of our ancestors survived.

A recent study published in Science suggests that a catastrophic "ancestral bottleneck" reduced the global population to just 1,280 breeding individuals, wiping out 98.7% of the early human lineage.

This population crash, lasting about 117,000 years, likely resulted from extreme climate shifts, prolonged droughts, and dwindling food sources.

Using a groundbreaking genetic analysis method called FitCoal, researchers analyzed modern human genomes to trace this dramatic decline, potentially explaining a gap in the African and Eurasian fossil record.

Despite the near-extinction, this bottleneck may have played a crucial role in shaping modern humans. Scientists believe it contributed to a key evolutionary event—chromosome fusion—which may have set Homo sapiens apart from earlier hominin species, including Neanderthals and Denisovans. The study raises intriguing questions about how this small population survived, possibly through early fire use and adaptive intelligence. Understanding this ancient crisis helps scientists piece together the story of human evolution and the resilience that allowed our species to thrive against all odds.

learn more https://www.eurekalert.org/news-releases/999720

15/12/2024

We aren't the only human species to have ever walked on the face of the Earth.

We, homo sapiens, have a close relative with a tragic history - the Neanderthals or the neanderthalensis.

These cousins of ours lived in Europe and West Asia about 45,000 years ago. Even though we share 99.7% of our DNA with the Neanderthals, we look slightly different from each other. Compared to humans, Neanderthals were shorter and thicker, had more developed jaws and weak chins.

They also had large nostrils that allowed them to breathe the cold air in Europe. Interestingly, Neanderthals had bigger heads and thus bigger brains than our ancestors. It is unclear whether this made them extra clever. But if we were so similar in many ways, why did we survive while they went extinct? The Neanderthals disappeared from different parts of Europe at different time points. The reasons behind their disappearance varied from one location to another. Similar to modern extinction of animals, Neanderthals may have disappeared due to competition and environmental factors. For centuries, our ancestors, who gave rise to modern humans, lived alongside the Neanderthals and both of them may have interbred, which shaped the evolution of modern humans. Neanderthals had bodies that evolved to withstand cold, while Homo sapiens had technology on their side.

Humans sewed clothing with needles and lived in complex shelters. They hunted a wide range of animals, birds, and fish with bows and arrows. Unlike Neanderthals, our ancestors may have also lived in larger groups. This allowed them to develop advanced social and cognitive skills. With all these factors, Homo sapiens could have simply been better equipped to survive. At the same time, Neanderthals had a shorter lifespan. Their children died at an earlier age. Ultimately, the emergence of a new, technologically more advanced species called humans, may have created too much of a pressure for the Neanderthals. Recent findings, however, suggest that Neanderthals were as smart as Homo sapiens. They invented similar tools and developed a culture of their own.

The only big difference seems to lie in the size of their groups. They formed smaller communities that lived far from each other. It turned out that networking was as important back then as it is now. As small groups disappeared, their culture and progress perished with them. Climate could have also played a role in the disappearance of the Neanderthals. 70,000 to 12,000 years ago, the climate greatly fluctuated.

There is evidence of dramatic cold waves that roughly coincide with the extinction of the Neanderthals. Imagine being used to living in a warm and mild land, when suddenly you are surrounded with icebergs or violent erupting volcanoes.

They had to rebuild their shelters, get accustomed to hunting new species and gathering new plants. Even though it is unlikely that a major environmental disaster killed the Neanderthals, these constant shifts in climate could have been detrimental to their survival. One theory suggests that Neanderthals may have also engaged in violent clashes with their rival Homo sapiens. It’s unlikely to be the case because Neanderthals were powerful hunters who couldn’t be easily wiped out in battle. Another theory suggests that Neanderthals died out because of deficiencies in their diet. During cold conditions where plants hardly grow, Neanderthals relied on meat as their source of energy.

Meat is rich in protein, but their bodies were not equipped to metabolize high amounts of protein. And since winters were long, they were forced to eat meat for long periods of time, which may have contributed to their extinction. In reality, the Neanderthals never perished. They live in us. Our ancestors may have interbred with the Neanderthal and passed on their DNA to us.

Analysis of human DNA showed that up to 4% of modern human DNA may have come from the Neanderthals. Neanderthals are not the only long lost human species. Denisovans from Siberia faced the same fate as our ancestors slowly spread around the globe. Unfortunately, we have far too little data to understand the interactions between these coexisting species. Perhaps, an unexpected finding will change our view of our cousin species once and for all.

22/07/2024

Estudo reescreve a História: OS PRIMEIROS HUMANOS CHEGARAM À PENÍNSULA IBÉRICA HÁ 1,3 MILHÕES DE ANOS

Alguma vez se perguntou quando é que os primeiros humanos pisaram a Europa? Um novo estudo sugere que isso aconteceu muito antes do que os cientistas pensavam – e de uma forma surpreendente.

Imagine uma época muito anterior à invenção da roda ou da escrita. Estamos a falar de há cerca de 1,3 milhões de anos.

É nessa altura que os investigadores acreditam agora que os primeiros seres humanos chegaram à Europa, mais concretamente ao atual sul de Espanha.

Uma equipa de cientistas espanhóis, liderada por Lluís Gibert, investigador da Universidade de Barcelona, tem estado a escavar o passado num local chamado Orce, no sul de Espanha.

O que descobriram é bastante surpreendente: os restos humanos mais antigos alguma vez descobertos na Europa. Os investigadores afirmam que as suas descobertas podem reescrever a história da migração humana.

Então, como é que os investigadores sabem a idade destes restos mortais? É aqui que entra a ciência. Os investigadores, que publicaram os resultados do seu estudo no início do mês na revista Earth-Science Reviews, utilizaram uma técnica chamada paleomagnetismo.

O paleomagnetismo é como ler o diário magnético da Terra. Os investigadores observam que os pólos magnéticos do nosso planeta se invertem de tempos a tempos. Essa inversão deixa uma marca em certos minerais, como uma espécie de tinta invisível.

Os cientistas podem ler estas marcas para descobrir quando é que as coisas aconteceram no passado.
(...)
“Defendemos a hipótese de que os humanos chegaram à Europa pelo Estreito de Gibraltar, porque não foram encontrados vestígios mais antigos em nenhum outro local da rota alternativa”, acrescenta Gibert.

Os investigadores estabelecem um paralelo intrigante com outra migração humana antiga. “A humanidade chegou à Europa quando dispunha da tecnologia necessária para atravessar barreiras marítimas, como aconteceu há um milhão de anos na ilha das Flores, na Indonésia”, diz Gibert.

Isto sugere que os nossos antigos antepassados eram marinheiros mais capazes do que se pensava.
ZAP //

Ler artigo completo em: https://zap.aeiou.pt/estudo-reescreve-a-historia-os-primeiros-humanos-chegaram-a-espanha-ha-13-milhoes-de-anos-615518

11/06/2023

How farming reshaped our smiles and our speech

19/05/2023

Prehistoric hearths found near Madrid date back about 250,000 years, with nearby tools showing food traces

30/03/2023

The first ancient DNA sequences from peoples of the medieval Swahili civilization push aside colonialist stories and reveal genetic connections from the past.

Endereço

Universidade Da Madeira
Madeira
9020-105

Horário de Funcionamento

Segunda-feira 08:30 - 17:30
Terça-feira 08:30 - 17:30
Quarta-feira 08:30 - 17:30
Quinta-feira 08:30 - 17:30
Sexta-feira 08:30 - 17:30

Telefone

+351291705390

Notificações

Seja o primeiro a receber as novidades e deixe-nos enviar-lhe um email quando Laboratório de Genética Humana - UMa publica notícias e promoções. O seu endereço de email não será utilizado para qualquer outro propósito, e pode cancelar a subscrição a qualquer momento.

Compartilhar