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New research reports novel molecular and pathways alterations associated with AD pathology. These findings are relevant ...
09/04/2021

New research reports novel molecular and pathways alterations associated with AD pathology. These findings are relevant for the development of personalized diagnosis and treatment approaches in AD.

Background Multiple pathophysiological processes have been described in Alzheimer’s disease (AD). Their inter-individual variations, complex interrelations, and relevance for clinical manifestation and disease progression remain poorly understood. We hypothesize that specific molecular patterns in...

Experts and patients see things differently when it comes to research milestones.
07/04/2021

Experts and patients see things differently when it comes to research milestones.

Background Commentators suggest that patients have unrealistic expectations about the pace of research advances and that such expectations interfere with patient decision‐making. Objective The obj...

"Glial cell line-derived neurotrophic factor plays an important role in the protection of dopaminergic neurons, but ther...
05/04/2021

"Glial cell line-derived neurotrophic factor plays an important role in the protection of dopaminergic neurons, but there are few reports of the relationship between GDNF and its precursors and cognitive impairment in Parkinson’s disease."

Neural Regen Res, Official publication of Publishing House of Neural Regeneration Research China Association of Rehabilitation Medicine,China

All Parkinson's research that is being conducted in the next year in one place.
29/03/2021

All Parkinson's research that is being conducted in the next year in one place.

# # # # At the start of each year, it is a useful practise to layout what is planned over the next 12 months. The events that are scheduled for the year to come, so that we can keep an eye out for …

"Because of its vast complexity, it is no surprise that we continuously learn new things about the brain."
26/03/2021

"Because of its vast complexity, it is no surprise that we continuously learn new things about the brain."

In this feature, we outline some studies that are helping to change the way we see our brain and how it interacts with the rest of our body.

The Parkinson's Disease Treatment Market is expected to exceed more than US$ 6.0 Billion by 2024 at a CAGR of 6% in the ...
24/03/2021

The Parkinson's Disease Treatment Market is expected to exceed more than US$ 6.0 Billion by 2024 at a CAGR of 6% in the given forecast period.

Dec 17, 2020 (Heraldkeepers) -- The Parkinson's Disease Treatment Market is segmented on the lines of its drug class, distribution channel, patient care...

"Advances made by basic, translational, and clinical neuroscience research in the next 50 years have great potential for...
22/03/2021

"Advances made by basic, translational, and clinical neuroscience research in the next 50 years have great potential for lasting improvements in human health, the economy, and society."

On the 50th anniversary of the Society for Neuroscience, we reflect on the remarkable progress that the field has made in understanding the nervous system, and look forward to the contributions of the next 50 years. We predict a substantial acceleration of our understanding of the nervous system tha...

"Although further clinical studies should clarify whether BBB disruption is a specific feature of AD pathogenesis, incre...
19/03/2021

"Although further clinical studies should clarify whether BBB disruption is a specific feature of AD pathogenesis, increasing evidence indicates that each component of the neurovascular unit is significantly affected in the presence of AD-related pathologies in animal models and human patients."

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer's Disease.

After exclusion of PD cases with known mutations, the study demonstrated that carriers of single mutations were at a sma...
17/03/2021

After exclusion of PD cases with known mutations, the study demonstrated that carriers of single mutations were at a small but significantly increased risk of PD.

Abstract. Biallelic Parkin (PRKN) mutations cause autosomal recessive Parkinson’s disease (PD); however, the role of monoallelic PRKN mutations as a risk factor

"Stern said the two-phase process described in the study “is the basic engine that drives most or even all forms of dege...
17/02/2021

"Stern said the two-phase process described in the study “is the basic engine that drives most or even all forms of degeneration forward.""

Rice University biochemists have proposed that degenerative diseases as varied as Alzheimer's, Parkinson's and muscle atrophy occur in two distinct phases marked by protein signaling changes that could result in patients responding differently to the same treatment.

"In animal models of these diseases, restoration of OXR1 has been shown to reduce or eliminate the deleterious effects o...
15/02/2021

"In animal models of these diseases, restoration of OXR1 has been shown to reduce or eliminate the deleterious effects of oxidative stress induced cell death, delay the onset of symptoms, and reduce overall severity."

Parkinson’s disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal damage resulting from ischemia are among the notable neurodegenerative diseases in which oxidative stress occurs shortly before the onset of neurodegeneration. A shared feature of these diseases is the depletion...

Dopamine is a neurotransmitter, a chemical that helps send messages in the brain. In people with Parkinson’s disease, th...
12/02/2021

Dopamine is a neurotransmitter, a chemical that helps send messages in the brain. In people with Parkinson’s disease, the neurons in the brain that produce dopamine die off.

Parkinson's Disease (PD) affects ~10 million people worldwide. Recent research is close to understanding the changes within individual cells causing PD.

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