10/12/2025
We’re proud to share that our own Clint Valentine is a co-author on a new publication in Bioinformatics Advances introducing MutSeqR, an open-source R package for analyzing error-corrected sequencing (ECS) data for applications in genetic toxicology.
At Fulcrum, we’ve been contributing to the open-source foundations of error-corrected sequencing for more than a decade, so this collaboration between Health Canada | Santé Canada and University of Ottawa feels especially meaningful.
MutSeqR provides a standardized, easy-to-understand workflow for analyzing ECS data across technologies like Duplex Sequencing and SMM-Seq, helping researchers and regulators interpret mutation frequency, dose-response, and mutational spectra with greater consistency.
“This work reflects my (and our) commitment to open and reproducible science,” said Clint. “It’s rewarding to see the tools we helped build become part of frameworks that support regulatory standard-setting and public benefit too. We see MutSeqR as part of a broader shift toward community maintained and open genomics methods that support regulatory genetic toxicology decision-making—bridging research, policy, and public health with shared analytical standards.”
📄 Read the paper: https://doi.org/10.1093/bioadv/vbaf265
💻 Explore the code: github.com/EHSRB-BSRSE-Bioinformatics/MutSeqR
Read more about the project and what’s next for open-source ECS analysis on our blog:
🔗 https://blog.fulcrumgenomics.com/p/mutseqr-open-standards-for-error
