Ameres Lab

The Ameres Lab is a molecular biology research group at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna, Austria.

The implementation of distinct gene expression profiles is essential for organismal development, physiological responses to external stimuli and pathogens, and defines a primary cause for disease. We are fascinated by the molecular events that control these processes at the post-transcriptional level by focusing on two major areas:

Small RNA silencing. Small silencing RNAs regulate gene expressio

n in nearly all eukaryotes and have enormous biotechnological and therapeutic potential. Among these, microRNAs belong to the larges family of trans-acting gene regulatory molecules in multicellular organisms. In flies and mammals, they control more than half of the protein-coding transcriptome, and act as key regulators of organismal development, physiology, and disease. We are interested in molecular mechanisms that govern small RNA silencing pathways in flies and mammals. Our focus lies on processes that regulate the production of small RNAs, their assembly into functional ribonucleoprotein complexes, and the disassembly thereof in response to synthetic and natural triggers. Our goal is to unravel mechanistic principles of small RNA-mediated gene regulation, a phenomenon that impacts virtually every aspect of metazoan biology. The Epitranscriptome. For RNA to fulfil its essential function within the cellular environment, numerous chemical modifications have evolved to sculpt its physical and functional interactions. Although more than hundred types of RNA modifications have built the descriptive foundation of what is referred to as the epitranscriptome, their mode of action remains largely unknown. We are studying the function of chemical RNA modifications, at the intersection of small RNA silencing pathways and general RNA metabolism. Our focus lies on the post-transcriptional addition of nucleotides to the 3´ end of RNA (i.e. tailing) by the only rudimentary characterized enzyme family of terminal nucleotidyltransferases in order to dissect the regulation of microRNA biogenesis and function; and the role of small RNA ribose methylation in order to gain insights into the antiviral immune response through the RNAi pathway in flies. The emerging concepts will inevitable impact our view on more general functions of post-transcriptional modifications in RNA metabolism. And we are applying our mechanistic insights to the development of novel epitranscriptomics approaches to probe post-transcriptional gene regulatory networks at the transcriptome-wide level. Drosophila melanogaster provides a unique combination of in vitro biochemical methods, cell culture experiments, and in vivo genetics to dissect the mechanisms and biological implications of RNA silencing. We are combining the strength of this model organism with the power of modern deep-sequencing technology and bioinformatics. The hypotheses that emerge from our fly studies are directly tested in human cell extracts and in cultured mammalian cell lines in order to determine the conservation and divergence of key principles in small RNA-mediated gene regulation and RNA metabolism in flies and mammals. Overall, our goal is to determine fundamental biological mechanisms of post-transcriptional gene regulation through pathways with enormous biological, biomedical, and technological impact.

01/10/2024

Great Master's project ahead! 👀 The Ameres lab is looking for a student to systematically dissect the RNA exosome, a key player involved in RNA processing and degradation in the mammalian system 🧫 Read more ➡️ https://tinyurl.com/uakz5psy

05/07/2024

🚨 Paper Alert! In Nature Methods, a Vienna BioCenter-wide collaboration involving Perutz group leader Stefan Ameres, Julius Brennecke and Ulrich Elling from Institute of Molecular Biotechnology, and Alexander Stark from Research Institute of Molecular Pathology (IMP), has developed ORFtag - a groundbreaking method to systematically investigate proteins and their functions 🙌 This innovative technique tags proteins in mammalian cells, enabling genome-wide screens of protein functionality with remarkable efficiency.

More info ➡️ https://tinyurl.com/8khp6bdp

Universität Wien
Medizinische Universität Wien

08/02/2024

🔎 New ahead: The lab of Stefan Ameres is looking for a research assistant/lab manager with good organisational skills and a passion for science 🤝 The lab's goal is to investigate fundamental cellular mechanisms in the regulation of gene expression and RNA metabolism 🧫

More information ➡️ http://tinyurl.com/r6bpb6sd

11/04/2023

🚨 Deadline reminder! Don't miss out on Microsymposium, our international conference on . The last day to register is April 19. https://bit.ly/microsymp23

Organizers: Institute of Molecular Biotechnology, Gregor Mendel Institute, Research Institute of Molecular Pathology (IMP), Max Perutz Labs Vienna, Austrian Academy of Sciences

Event Sponsors: Eclipsebio, The Company of Biologists, New England Biolabs, Lexogen, QIAGEN, Sino Biological, Inc. ZEISS Group

Our amazing speaker line-up:
🧬 Yiliang DING, John Innes Centre
🧬 Olivier DUSS, EMBL
🧬 Niels GEHRING, University of Cologne
🧬 Torben HEICK JENSEN, Aarhus University
🧬 Florian HEYD, Freie Universität Berlin
🧬 Valérie HILGERS, Max Planck Institute of Immunobiology and Epigenetics
🧬 Axel INNIS, Institut Européen de Chimie et Biologie (IECB)
🧬 Joanna JACHOWICZ, Institute of Molecular Biotechnology
🧬 Stefanie JONAS, ETH Zurich
🧬 Joshua MENDELL, UT Southwestern Medical Center
🧬 Marlene OEFFINGER, Montreal Clinical Research Institute (IRCM)
🧬 Ramesh PILLAI, University of Geneva
🧬 Geraldine SEYDOUX, Johns Hopkins University
🧬 Irina SOLOVEI, LMU Munich
🧬 Felipe Karam TEIXEIRA, University of Cambridge
🧬 Nadine VASTENHOUW, University of Lausanne
🧬 Karsten WEIS, ETH Zurich

15/02/2023

14/08/2022

The Ameres lab is looking for a highly motivated Research Assistant/Labmanager with organizational talent and a passion for science.
➡️ Read more: https://bit.ly/3Pft9Ea
Universität Wien

29/11/2021

Congratulations to Stella for a great Master Thesis defense! It has been great to have you in the lab! Thanks a lot for your contributions and all the best for your future!

04/05/2021

We are looking for an experienced research technician!

Interested in cell cultures and the regulation of gene expression and RNA metabolism? 🔬 Then this might be something for you: the Ameres Lab is looking for a highly motivated research assistant with a passion for science to join the team.
https://bit.ly/3telN8O

Register for the upcoming Microsymposium! Excellent speaker list! As always, registration is free of charge!

18/02/2021

Registration for the 15th microsymposium on small RNA biology in April is now open!

Apply for PhD and Postdoc speaker slots, and share your exciting results with the RNA community!

http://imba.oeaw.ac.at/microsymposium

Research Institute of Molecular Pathology (IMP)
GMI - Gregor Mendel Institute of Molecular Plant Biology
Max Perutz Labs
Vienna Biocenter Scientific Training

21/12/2020

Congratulations to Raphael (and all other recipients) for receiving the Vienna BioCenter PhD award! We are very proud of you!

Each year the Vienna BioCenter awards prizes for the best theses of the year. The winners in 2020: Borja Mateos (Konrat Lab), Anete Romanauska (Köhler Lab), Raphael Manzenreither (Ameres Lab), Maria Inês Leça (Keays Lab). Congratulations!!
Research Institute of Molecular Pathology (IMP)
Universität Wien
Max Perutz Labs
Medizinische Universität Wien
Vienna Biocenter Scientific Training

29/10/2020

02/10/2020

Very happy to be joining the Max Perutz Max Perutz Labs Vienna !

We are happy to welcome Stefan Ameres - new group leader at the Perutz and Professor for RNA biology at Universität Wien! 🎉 Stefan and his lab will focus their reseach on the mechanism and biology of RNA silencing.
Learn more about his work: https://www.maxperutzlabs.ac.at/research/research-groups/ameres
Foto: Hannes Tkadletz

Adresse

Dr./Bohr-Gasse 3
Wien
1030

Webseite

http://www.imba.oeaw.ac.at/research/stefan-ameres/

Benachrichtigungen

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