27/05/2026
๐ง๐๐ ๐ฃ๐ฟ๐ผ๐ฑ๐๐ฐ๐ ๐๐ถ๐ด๐ต๐น๐ถ๐ด๐ต๐๐: ๐๐ถ๐ด๐ต๐น๐ ๐ฆ๐ฒ๐น๐ฒ๐ฐ๐๐ถ๐๐ฒ ๐๐ฒ๐น๐น-๐๐๐น๐๐๐ฟ๐ฒ-๐๐ฟ๐ฎ๐ฑ๐ฒ ๐๐ฆ๐๐ฏ ๐๐ป๐ต๐ถ๐ฏ๐ถ๐๐ผ๐ฟ ๐ณ๐ผ๐ฟ ๐ถ๐ฃ๐ฆ ๐๐ฒ๐น๐น ๐ฅ๐ฒ๐ฝ๐ฟ๐ผ๐ด๐ฟ๐ฎ๐บ๐บ๐ถ๐ป๐ด ๐ฎ๐ป๐ฑ ๐ข๐ฟ๐ด๐ฎ๐ป๐ผ๐ถ๐ฑ ๐๐๐น๐๐๐ฟ๐ฒ
CHIR 99021 is a small-molecule inhibitor with high specificity for glycogen synthase kinase 3 (GSK-3). Inhibition of GSK-3 stabilizes ฮฒ-catenin, resulting in activation of Wnt target genes and promotion of long-term self-renewal. Mechanistically, this involves suppression of T-cell factor 3 (Tcf3), itself a transcriptional repressor of key pluripotency factors such as Oct4, Sox2, and Nanog.
Accordingly, CHIR 99021 is widely used in chemical reprogramming cocktails for iPSC generation, as well as in organoid culture systems where Wnt activation is required. We offer two grades of CHIR 99021: a general-use grade and a cell culture grade, the latter of which has been tested for endotoxin and mycoplasma contamination for your peace of mind.
๐๐๐๐ซ๐ง ๐๐จ๐ซ๐: https://www.tcichemicals.com/BE/en/product/tci-topics/ProductHighlights_20260525
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๐จ๐ซ ๐๐ง๐ช๐ฎ๐ข๐ซ๐ข๐๐ฌ/๐๐ซ๐๐๐ซ๐ฌ: ๐ฉ [email protected]