06/12/2026
For decades, the conversation around impact sports and brain health has been dominated by a sense of inevitability. We know that thousands of sub-concussive "micro-hits" (Repetitive Head Acceleration Events) accumulate over a single season, quietly triggering neuroinflammation 🧠
Until now, our approach has been almost entirely reactive. But a groundbreaking new study published in the Journal of Neurotrauma by researchers at the University of Utah provides the first clinical evidence that we can make the brain itself more resilient before the impacts occur.
The Study by the Numbers: Dr. Hannah Lindsey, Dr. Elisabeth Wilde et al. ran a randomized, double-blind, sham-controlled trial tracking 26 active NCAA Division I football players over a full 16-week season 💡
Using advanced diffusion MRI, they tracked two key structural biomarkers: Restricted Diffusion Imaging (RDI) for neuroinflammation, and Quantitative Anisotropy (QA) for axonal stress.
The Findings ("Fire vs. Ice"):
The Sham Group (Unprotected): Displayed a massive, statistically significant spike in neuroinflammation (RDI) and axonal stress across white-matter tracts. In fact, 50% of the variance in their brain inflammation was driven directly by the cumulative hits of the season. The damage concentrated heavily in the "Cone of Vulnerability"—deep brain regions like the midbrain and brainstem.
The Active itPBM Group: Despite taking the exact same hits on the field, the athletes using our intranasal-transcranial photobiomodulation (itPBM) device 3 days a week showed remarkable brain stability. They experienced no significant increases in inflammation, and deep survival structures were completely spared.
Why the "Nasal Key" Matters: Standard transcranial headsets can only reach the top and sides of the skull. By combining transcranial LEDs with a patented intranasal module (projecting 810 nm near-infrared light pulsed at 40 Hz Gamma), the light reaches the ventral underside and deep midbrain structures often missed by standard gear.
The Bigger Picture: This clinical validation lays the groundwork for an even larger milestone. The U.S. Department of Defense has awarded a landmark $4.6M grant to the University of Utah and NYU to launch a massive 300-participant clinical trial. This study will investigate our itPBM technology as a drug-free intervention to restore brain health, improve mood, and mitigate chronic symptoms for service members, veterans, and first responders living with mTBI: https://medicine.utah.edu/neurology/news/2025/12/shining-new-light-treatment-traumatic-brain-injury
We are entering a new era of brain resilience. Read the full published study summary here: https://www.vielight.com/blog/utah-neurotrauma-study-advanced-diffusion-mri-brain-resilience-vielight-neuro/