25/07/2024
Creatine monohydrate CAS 6020-87-7
Introduction:
Introduction: Creatine monohydrate is a pharmaceutical raw material and a dietary supplement additive. It can inhibit the generation of muscle fatigue factors, alleviate fatigue and tension, restore physical fitness, accelerate protein synthesis in the human body, make muscles more robust, enhance muscle elasticity, reduce cholesterol, blood lipids, and blood sugar levels, improve muscle atrophy in middle-aged and elderly individuals, and delay aging.
Uses: It is utilized as a food additive, cosmetic surfactant, feed additive, beverage additive, pharmaceutical raw material, and dietary supplement additive. It can also be directly formulated into capsules, tablets, or taken orally.
Nutritional Fortifier: Creatine monohydrate is acclaimed as one of the most popular and effective nutritional supplements, standing alongside protein products as one of the "best-selling supplements." It is considered a "must-use" product for bodybuilders and is widely used by athletes in various sports such as soccer and basketball to enhance energy levels and strength. Creatine is not a banned substance and is naturally present in numerous foods, making it permissible by any sports organization. According to a small-scale study in Japan, creatine monohydrate can improve muscle function in patients with mitochondrial diseases, although the extent of improvement varies based on individual biochemical and genetic characteristics of the patient's muscle fibers.
Production Route: The preparation method for creatine monohydrate includes the following steps: Step 1: Nucleophilic substitution reaction between hydroxyacetonitrile aqueous solution and methylamine aqueous solution to generate methylaminoacetonitrile, with a reaction temperature of 10°C to 40°C and a reaction time of 1 hour to 6 hours; Step 2: The reaction liquid of methylaminoacetonitrile from Step 1 undergoes hydrolysis in the presence of sodium hydroxide to obtain a solution of creatine sodium, with a hydrolysis temperature of 60°C to 80°C and a hydrolysis time of 2 hours to 6 hours; Step 3: Adjust the pH to 9 to 12, and conduct a condensation reaction with cyanamide to obtain creatine monohydrate, with a condensation temperature of 50°C to 90°C and a condensation time of 1 hour to 6 hours. The method of the present invention features mild reaction conditions, minimal by-products, and high yield, making it suitable for industrial production.
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