Miraculix-Lab

Name: Miraculix-Lab
Address: Hans Knöll Straße 6, Jena, 07745, DE
Telephone: +4936412716023

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Deutschland
Jena
Miraculix-Lab

University spin-off and inventor of the QTests, the first quantitative test kits for determining potencies at home. 🍄🔬

30/04/2026

🚀5 Years of Miraculix: Let’s Celebrate the Right Way!
Five years ago we started bringing science and subculture together and today we’re bigger than ever. Miraculix stands for evidence-based knowledge around psychedelics, Analysis, harm reduction and open minds. 🍄🔬
On June 19th, 2026 we’re celebrating at Rosenkeller Jena and we’re going all in.

🧠 Psychedelic & Drug Science Pub
Because the Miraculix feeling isn’t just about partying – it’s about creating real value. Where else do you get the chance to talk directly with scientists and researchers about psychedelic topics while the music is already playing? We’re bringing together some of the voices in psychedelic research for talks, discussions and a Psychedelic Quiz with prizes. Full speaker lineup in the slides above.

🎵 Live Music & 2 Floors of DJs
We are beyond grateful that so many talented local collectives and DJs are coming together to celebrate with us and support what we do. From House to Tekno, Hip Hop to Groove Techno this night is going to hit different. Full lineup in the slides above.

📍 Rosenkeller Jena | 🕗 8 PM | 🎟️ Entry €10
Over the next few days we’ll be sharing more about each part of the evening, the speakers, the music and everything in between.

Next week we’ll be launching presale tickets so keep an eye out!
If you have the chance to make it to Jena that night – you are more than welcome. We’d love to celebrate with you. Mush love ❤️

10/04/2025

Two types of self-grow mushrooms: 🍄
All-in-one bags and grain-only bags — which one do you prefer?

We’d love to hear your experiences with both types, your lessons learned, and which setup works best for you. In our latest blog, we dive deep more and give you tips, and also how to work for best conditions for each method.Check the full article via the link in our bio for all the insights.

Note: This guide is for educational purposes only. Psilocybin cultivation may be restricted or illegal depending on your location. Always research your local laws before starting.

08/04/2025

Is it really always what it seems? A small excerpt from our mobile setup in which identical looking 💊 were analyzed with our QTest.

The result clearly showed that these are 2 completely different substances. So stay safe.

03/04/2025

Exciting news. Next week we’re launching the very first edition of the miraculix Journal Club — and you’re invited to be part of it. If you don’t want to miss this
month’s topic, just comment “SCIENCE” below to get early access.

Each month, we select a HOT topic in the world of psychedelics — from groundbreaking research to practical, real-life questions — and break it down in a way that’s clear, accessible, and relevant.

We’ll share the core of the discussion sparked by your contributions in our posts, along with a take-home message shaped by the perspectives of the community.

That’s why your input matters. Sharing your knowledge, reflections, personal insights, or even questions in the comments is not only welcome — it’s essential. We’ll actively include selected contributions in the monthly summary to highlight the
richness of voices in our community. What you share might help someone else learn, reflect, or see things from a new angle.

Today’s topic: Can I test positive for magic mushroom consumption?

We explain how psilocybin is metabolized in the body, what drug tests can (and can’t) detect, and why timing plays a crucial role. We highly recommend reading the full article on our website, where we break everything down in detail and answer the most common questions. Link in bio

27/03/2025

Microdosing is trending—but what does the science actually say?

In our latest blog, we break down what microdosing really is, how it works, and what the
most recent research (as of 2025) reveals about its effects and risks. While many users
report mood boosts, creativity, and cognitive benefits, the science remains cautious.

Microdosing—the practice of taking small, sub-hallucinogenic doses of psychedelics like
L*D, psilocybin, or Amanita muscaria—has become increasingly popular. This post reviews
current data from clinical trials, sociological studies, and harm-reduction reports. Findings
are mixed. Some suggest microdosing may influence mood or neuroplasticity, but placebo
effects explain much of the hype. Risks like overstimulation, toxic exposure, and unregulated
products can’t be ignored.

In 2025, there’s still no gold-standard protocol, no universally safe compound, and no
one-size-fits-all answer. What we do know is that more rigorous research is urgently needed.
Until then, those exploring microdosing—clinicians, researchers, or individuals—must
proceed with curiosity, caution, and critical thinking.

We strongly recommend reading the full post for a clear and evidence-based perspective.
Link in bio.

20/03/2025

Do magic mushrooms go bad? 🍄🔬 You might think you know the answer, but do you know the scientific mechanisms behind it?

Mushrooms degrade over time, not just because of external factors but due to chemical as well as enzymatic oxidation. The characteristic blue discoloration seen when mushrooms are bruised is a sign of this enzymatic oxidation, but even in storage, degradation continues if conditions aren’t ideal. A study by Gotvaldová et al. (2020) examined the impact of storage on tryptamine stability, showing that dried mushrooms kept in the dark at room temperature retained the most psilocybin, whereas freezing caused significant loss.

In our latest blog post, we take a deep dive into how storage affects the potency of mushrooms and the best ways to prevent degradation. We also best insightsfrom Dr. Felix Blei and how to recognize microbial contamination and keep your mushrooms safe.

We strongly recommend reading the full post on our website, where we explain everything in detail—link in bio! 🔗

Have you ever noticed changes in potency over time? Share your experiences in the comments! 💬👇

06/03/2025

In connection with our scientific projects, we are funded by the Free State of Thuringia within the framework of the Thuringia Scholarship, with the project 2024 SU 0144, in accordance with the FTI-Thuringia PERSONS guideline. The aim of this funding is to promote the professional development of highly qualified specialists and scientists through targeted support and to retain them in Thuringia in the long term.

27/02/2025

How many Psilocybe species make hallucinogenic truffles? You know how you always make too many jars than you actually fruit? This was also true in our case with a jar of Psilocybe caerulescens. But wait, are these sclerotia? Has this even been documented? A publication from 1987 can be found in the literature [1]. Otherwise, our first brief search was unsuccessful. Of course, we couldn’t keep this from you, and perhaps it has been circulating in the Shroomery for a long time, but take a look for yourself and tell us about your own experiments.

You may remember a post some time ago when we tried to get various Psilocybe species to bear fruit in the laboratory. One of them was Psilocybe caerulescens, grown from a spore print that Alan sent us along with other exciting species. Thank you 🥰

But what are sclerotia? The ones shown in Slide 7 were formed by P. tampanensis, representing a subterranean survival stage. They do not help with reproduction. The sclerotia shown were grown on a supplemented grain mixture in screw-top jars for 3 months in the dark. In the sclerotia, the mycelium is highly condensed and is surrounded by a thick cortex layer to survive, for example, persistent dry periods or forest fires [2].

The exciting thing is that so far, all truffle strains can be traced back to Psilocybe mexicana and Psilocybe tampanensis, and we are not aware of any other sclerotia production in the genus Psilocybe. If you look at current phylogeny analyses, however, it seems absolutely logical that P. caerulescens is also capable of producing sclerotia, as it is in the /Mexicanae clade, along with P. mexicana, P. tampanensis, and P. samuiensis (ITS based). That means it has a common ancestor (section Mexicanae) [3].

The source is a Biorvix paper by and and our Psilocybe bioinformatics Godfather Jason Slot, among others.

What do you say? Should I harvest the single jar, clone the truffles, then freeze-dry and analyze them with HPLC? Who else is curious to know how much content the truffles have and which other alkaloids or natural substances are present?

25/02/2025

miraculix WIP 🧪🥼

20/02/2025

After the psilocybin-related topics have repeatedly received such great feedback from you, we’re continuing today with the next cracker. And with a paper that is particularly close to our hearts, because it comes from the Hoffmeister working group 🤎

In a collaboration between the University of Jena and the local HKI and MPI, Eike Schäfer and colleagues were able to show the production of over nine different terpenes, including β-copaene and δ-cadinene in the fruiting bodies of Psilocybe cubensis. You can see which terpenes were also found in the in-vitro product assays of P. cubensis in the start graphic and Figure 7. However, it was not only possible to detect these terpenes, but also how the fungi produce these known natural substances. The enzyme CubA was identified as a multifunctional sesquiterpene synthase. CubA was four-fold upregulated in fruiting bodies vs. vegetative mycelium, which pointed to a function of this gene in the mushrooms.

And now the most exciting part: Thanks to bioinformatics, we can already assume that all psilocybin-producing fungi also produce terpenes. A whole range of them revealed an unexpected wealth of genes putatively encoding sesquiterpene synthases, ranging from 17 genes in P. mexicana to 24 in P. serbica. Intriguingly, both P. cubensis, P. cyanescens, and P. serbica encode only a single gene for a clade II synthase. Yet, the only literature available regarding Psilocybe terpenoids is a single report on a seco-aromadendrane-type, ledene-derived sesquiterpenoid, psilosamuiensin A in P. samuiensis.

This publication once again focuses on the diversity of natural substances produced by Psilocybe and shows how little we know about the other ingredients and their cumulative effects. In addition to various tryptamines, beta-carbolines, lumichromes, and diketopiperazines, yet another class of natural substances has now been identified in magic mushrooms. Once again, a direct comparison can be drawn with cannabis, which also contains a large number of different active substances, including a variety of terpenes that modulate the effect of cannabinoids (entourage effect).

13/02/2025

After last week’s discussion on strain variability and the influence of cultivation conditions, we move forward with two key publications: Bradshaw et al. (2024) and Maekawa et al. (2020)—studies that add valuable insights to the ongoing discourse.

However, we’ve noticed that our content is often hidden from our audience, limiting access to
these important discussions. To ensure that no valuable knowledge is lost, we’re launching
The miraculix Journal Club—a dedicated space where scientific literature is critically examined, discussed, and questioned within a community that values deep inquiry and knowledge-sharing.

For scientists, journal clubs are more than just reading groups—they are a vital part of scientific training. These gatherings help researchers stay updated with the latest discoveries, refine their critical thinking, and engage in deep discussions about methodology,
results, and implications. It’s where ideas are challenged, perspectives are broadened, and
the true meaning of scientific inquiry comes to life. Now, we’re bringing this tradition beyond
the lab and into the community. Curious to join? Comment “SCIENCE” below, and we’ll send
you the registration details.

This Week’s Topic: The Evolutionary Mystery of Psilocybin. For over 70 million years, certain
fungi have retained the ability to produce psilocybin. Why did psilocybin evolve in fungi?

Recent genomic studies suggest that the psilocybin biosynthetic gene cluster (BGC) was
transferred across species through horizontal gene transfer (HGT) rather than evolving in a
single lineage. This strongly implies an adaptive advantage—but for what purpose? Was
psilocybin developed as a defense mechanism, an ecological adaptation, or something else
entirely? Nature rarely does things by accident.

What do you think? Drop your thoughts below!

Adresse

Hans Knöll Straße 6
Jena
07745

Telefon

+4936412716023

Webseite

https://uswebshop.miraculix-lab.com/, https://www.miraculix-lab.de/en, https://euwebshop.miraculix-lab.de/

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