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GeneXplain - Science is good

Name: GeneXplain - Science is good
Address: Am Exer 19b, Wolfenbüttel, 38302, DE
Telephone: +4953319922000

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GeneXplain - Science is good

Welcome to SCIENCE IS GOOD by geneXplain proud owners of TRANSFAC. We spread verified science facts across many fields. "Let's Question Everything."

Like, follow, & share for more fascinating insights. The geneXplain GmbH distributes software solutions for genome, network and compound analysis, in short: everything you need for life sciences oriented towards personalized medicine.The tools we distribute are handpicked based on their functionality and proven reliability, they will not let you down. The online platform we have developed integrat

es public and private domain sources, the best of both worlds: Everyone is invited to contribute!With geneXplain products, your research is off to a good start.

25/05/2026

A recent Council for Scientific and Industrial Research (CSIR, India)-led study used RNA-seq, machine learning, and deep learning to identify biomarkers associated with progression from dengue fever to severe dengue.
We were pleased to see TRANSFAC® used in the regulatory enrichment analysis. The study reported MTF-1 and Kaiso motif signals among differentially expressed genes, linking severe dengue progression to metal ion homeostasis, oxidative stress, ferroptosis, and stress-response regulation. This is exactly where curated regulatory knowledge adds value to AI-driven biomarker discovery: ML models can identify predictive signatures, while TRANSFAC® helps explain the regulatory mechanisms behind them.
Congratulations to the authors Srilekha Anumulapuri Dr. J J Venkata Nagamani . Dr. Agiesh Kumar Balakrishna Pillai Dr. Srinivasa Rao Mutheneni from Council for Scientific and Industrial Research (CSIR, India), , and Institute of Advanced Virology.
At geneXplain, we are proud to see TRANSFAC® supporting scientists in infectious disease research, biomarker discovery, and systems-level interpretation of transcriptomic data.
Read the paper: https://doi.org/10.1177/11769343261449312
Learn more about TRANSFAC®: https://genexplain.com/transfac-product/
Visit geneXplain: www.geneXplain.com

06/05/2026

“Pre-vaccination immune signatures of children with inborn errors of immunity associate with COVID-19 vaccine response” published in Human Vaccines & Immunotherapeutics.
Read the full paper: vhttps://doi.org/10.1080/21645515.2026.2661495 The study addresses an important question in modern vaccinology: Why do some individuals with inborn errors of immunity respond strongly to mRNA vaccination, while others show weaker humoral responses?

By profiling immune cell subsets before vaccination, the authors showed that vaccine responsiveness is already reflected in the pre-vaccination transcriptional state of the immune system. High responders displayed stronger inducible immune programs in activated memory B cells and peripheral T follicular helper cells, including genes such as NFKB1, CD69, TIGIT, CD40L, BATF, and BTK.
We were especially pleased to see that TRANSFAC® was used and cited in the regulatory interpretation of these findings. In the study, motif analysis using TRANSFAC helped enriched transcription factor binding motifs associated with vaccine-response-related gene signatures, highlighting candidate regulators such as NF-κB1, GATA1, HNF1B, and SND1.

For researchers working in gene regulation, immunology, vaccinology, systems biology, transcriptomics, and drug discovery, we invite you to subscribe to the geneXplain weekly newsletter to receive scientific insights. Subscribe here: https://genexplain.com/blog/

18/04/2026

Today is the final day to bridge the gap between “raw data” and “biological insight” while locking in your annual price (40% off) for future renewals (https://genexplain.com/35-year-anniversary-offer/).

While gene lists show you what is happening, TRANSFAC tells you why. By locking in your access today, you aren't just buying a database; you’re investing in a faster, more mechanistic route to your next publication or discovery.

How your research benefits today:
1. Pinpoint the exact transcription factors and master regulators driving your expression profiles.
2. Trace gene expression changes back to their upstream signaling pathways with evidence-based precision.
3. Identify actionable drug targets and biomarkers by integrating RNA-Seq, ChIP-Seq, and epigenomics into one unified workflow.

Eliminate guesswork by using a curated knowledgebase built on over 35 years of peer-reviewed data. Lock in your 35th Anniversary Pricing Here: https://genexplain.com/35-year-anniversary-offer/ Once reserved, it remains valid for the next 3 weeks, giving you time to discuss with your PI or procurement.

17/04/2026

2 days left: Lock it or miss it
Dear Researcher, If you’re working with omics data, this is not just another tool - it’s how you move from lists to real biological insight.
What you gain:
• Identify key transcription factors and master regulators
• Connect gene expression with upstream signaling
• Discover disease mechanisms, biomarkers, and drug targets
• Integrate RNA-Seq, ChIP-Seq, and other omics data into one coherent analysis
Secure your access now:
Click https://genexplain.com/35-year-anniversary-offer/ before April 17, 24:00 to reserve your discount.
Once reserved, it remains valid for the next 3 weeks, giving you time to discuss with your PI or procurement.

15/04/2026

Dear colleague, Less than 3 days remain to reserve your TRANSFAC discount (https://genexplain.com/35-year-anniversary-offer/), valid for 3 weeks once claimed.
Before you decide, we want to address the question we hear most often from academic users evaluating us against other tools: "What does TRANSFAC actually give me that I can't get elsewhere?" The honest answer is not a longer feature list. It's the data underneath the features. TRANSFAC is built on more than three decades of manual expert curation from primary literature. Every transcription factor binding site, every PWM, every regulatory interaction in TRANSFAC and TRANSPATH has been read, evaluated, and annotated by domain experts, not scraped, not predicted, not inferred from sequence similarity alone.

Reserve your discount, Click (https://genexplain.com/35-year-anniversary-offer/) before April 17, 24:00 to reserve your discount. Once reserved, it remains valid for the next 3 weeks, giving you time to discuss with your PI or procurement.

14/04/2026

Is AI predicting drugs, or is it actually making decisions? We discussed the critical gap in modern AI-driven drug discovery. While many AI models can generate a list of "relevant" drugs, they often fail to provide the mechanistic reasoning required to choose the right one.

TRANSFAC DISEASES: A comprehensive ecosystem that bridges the gap between DNA regulation and clinical therapy. By integrating 35+ years of structured biological knowledge with upstream analysis, TRANSFAC DISEASES moves beyond simple data integration into mechanism-based reasoning.

We’ve opened a limited anniversary offer for TRANSFAC® designed to support researchers working with multi-omics data. You can reserve the offer now and complete formal procedures afterwards (3 weeks), Secure your offer: https://genexplain.com/35-year-anniversary-offer/

14/04/2026

Dear Researchers, Today we’re opening a limited anniversary offer for TRANSFAC®, designed to support researchers working with multi-omics data.
TRANSFAC is designed to address this by enabling you to:
Identify key transcription factors and master regulators
Link gene expression changes to upstream signaling pathways
Move from descriptive data to mechanistic understanding
You can reserve the offer now (5 days) and complete formal procedures afterwards (3 weeks):
Secure your offer: https://genexplain.com/35-year-anniversary-offer/

13/04/2026

Dear Researchers, Today we’re opening a limited 35-Year Anniversary Offer for TRANSFAC®, designed to support researchers working with multi-omics data.

Include: A very special price for all TRANSFAC plans: https://genexplain.com/35-year-anniversary-offer/

+20–40% discount on TRANSFAC plans
+Annual price locked in for future renewals
+1–3 hours of expert support (over-the-shoulder guidance)
+Take up to 3 weeks to complete internal approvals, procurement procedures, and payment.

Watch a 3-minute video to see how this applies to your research: https://youtu.be/9PCQY_s8zNw

09/04/2026

The gold standard in transcription factor research is hitting a massive milestone. Next week, TRANSFAC® turns 35. To honour the community that made this possible, GeneXplain is launching the most significant offer in the history of the database.
These offers will be time-sensitive and exclusive. To ensure you receive the discount codes and consultation booking links the moment they go live, Subscribe to our Newsletter Here: https://genexplain.com/blog/

We aren't just offering a sale; we’re opening the doors to the future of your research. This is a once-in-a-lifetime opportunity to access world-class data at an unprecedented value:
Historic Discounts: The largest price reductions ever seen across all TRANSFAC® packages.
Expert Consultation: Complimentary sessions with our top bioinformaticians to help you maximize your data integration.
Unmatched Accuracy: Secure the latest version of the world's most deeply curated library of transcription factors and binding sites.

🔬 Why Now?
If you’ve been waiting for the "perfect time" to upgrade your lab's capabilities or switch to a licensed version, this is it. This deal is designed to ensure every researcher, from independent labs to global institutions has the tools they need to break new ground in 2026.

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