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Ipbln-Csic

Name: Ipbln-Csic
Address: Avenida del Conocimiento, 17, Granada, 18016, ES
Telephone: +34647716821

Casa
España
Granada
Ipbln-Csic

Instituto de Parasitología y Biomedicina López-Neyra. Conocer para curar. Instituto de Parasitología y Biomedicina López-Neyra (ipbln).

Centro de en , Consejo Superior de Investigaciones Científicas

29/05/2026

Today Dr. Alexandre Calon (Head of the Translational Research in Tumor Microenvironment Laboratory) has given a seminar at IPBLN.

Titled: ‘Beyond Cancer Cells: The Tumor Microenvironment in Precision Oncology’.

The lecture has explored the role of the tumor microenvironment in cancer progression and treatment response. It has highlighted recent findings on how cancer-associated fibroblasts shape therapy resistance, tumor immunity, and the development of precision oncology strategies.

Alexandre Calon leads the Translational Research in Tumor Microenvironment (TReaTME) laboratory at the Hospital del Mar Research Institute (IMIM, Barcelona, Spain). His research focuses on how tumor–stroma interactions influence metastasis and therapy resistance, particularly in colorectal and breast cancer. The lab combines patient-derived organoids, primary stromal cells, humanized immunocompetent models, and molecular profiling of patient samples to study cancer-associated fibroblasts, immune regulation, and mechanisms of treatment response. Projects are closely integrated with prospective patient studies and clinical trials, aiming to advance clinically relevant biomarkers and personalized medicine.

27/05/2026

Ayer los alumnos que han participado en el proyecto PIIISA de este año expusieron en el Parque de las Ciencias sus resultados.

8 alumnos del IES Francisco Ayala en colaboración con:

- Fuencisla Matesanz
- Unidad de cultivos celulares: María del Carmen Ruiz
- Unidad de microscopía: Laura Montosa y Flores García San José
- Unidad de genómica: Alicia Barroso y Luz Canet
- Unidad de Bioinformática: Eduardo Andrés León, Daniel J. García, Gonzalo Ariza, Laura C. Terrón.

Durante este proyecto han aprendido a trabajar como auténticos investigadores biomédicos:
✨ Cultivando células en laboratorio
✨ Aplicando tratamientos con rotenona para inducir disfunción mitocondrial
✨ Comparando células tratadas con grupos control (WT)
✨ Analizando las mitocondrias mediante microscopía para observar cambios en su morfología y actividad
✨ Estudiando cómo la inhibición mitocondrial puede provocar fragmentación y alteraciones celulares
✨Realizando análisis de RNA-seq diferencial para identificar genes y rutas biológicas afectadas
✨Aprendiendo a exponer resultados científicos mediante la elaborando un póster científico y compartiendo sus resultados con la sociedad en el Parque de las ciencias de Granada

Todo ello relacionando sus resultados con enfermedades neurodegenerativas como el Alzheimer o la esclerosis múltiple.

Una experiencia única donde han podido acercarse a la investigación desarrollar pensamiento científico y descubrir cómo la biología molecular ayuda a entender enfermedades complejas.

27/05/2026

El pasado jueves vino el Centro de Dia AMAL de aldeas infantiles ( ) a realizar dos talleres al IPBLN. Lo pasaron genial haciendo pulsera genéticas y extracción de ADN 🤯

Gracias a la actividad, los niños y niñas se divirtieron y salieron emocionados con su ADN🧬

25/05/2026

📅ACTIVIDADES DE LA SEMANA EN EL IPBLN → del 25 al 29 de Mayo 2026

# SEMINARIO EXTERNO - VIERNES 29 de Mayo

Este viernes vendrá el Dr. Alexandre Calon, Head of the Translational Research in Tumor Microenvironment Laboratory (IMIM, Barcelona, Spain) con su ponencia.

Título: ‘Beyond Cancer Cells: The Tumor Microenvironment in Precision Oncology’

🕛 Hora: 12:00
📍 Lugar: Salón de actos IPBLN

📅WEEKLY ACTIVITIES AT IPBLN → May 25-29, 2026

# SEMINAR - FRIDAY, May 29th

This Friday Dr. Alexandre Calon, Head of the Translational Research in Tumor Microenvironment Laboratory (IMIM, Barcelona, Spain) will host a seminar here at the IPBLN.

Title: ‘Beyond Cancer Cells: The Tumor Microenvironment in Precision Oncology’

🕛 Time: 12:00 a.m.
📍 Place: IPBLN Conference Hall

22/05/2026

Today Dr. David Monchaud (ICMUB, Dijon, France) has given a seminar at the IPBLN.

Titled: “Chemical Modulation of DNA/RNA G-Quadruplex (G4) Structures in Human Cells”.

Guanine (G)-rich DNA and RNA sequences can uniquely fold into structures known as G-quadruplexes (G4s). These four-stranded structures play key roles in DNA transactions (replication, transcription, repair) and genome stability. Over the past two decades, the field has evolved rapidly thanks to the development and use of small molecules—G4 ligands—designed to engage and probe G4s in cells. While thousands of ligands have been created, the ability to chemically destabilize them was long missing, precluding real chemical biology approaches. Surprisingly, the first hints of G4 destabilization came from TMPyP4—a molecule initially hailed as a G4 stabilizer. This study opened the way for new research into G4-unfolder molecules, culminating in PhpC, the most extensively studied destabilizer to date. PhpC has been shown to reshape DNA and RNA G4 landscapes in various cancer and neural cells, revealing the deep regulatory roles G4s play. This talk will explore the emergence of these molecules (referred to as molecular helicases) and their potential as both chemical biology tools and therapeutic agents in G4-linked diseases, including age-related disorders. The field now stands at an exciting turning point—where disrupting G4s may be just as powerful as stabilizing them.

21/05/2026

Esta semana visitaron el Instituto de Parasitología y Biomedicina López-Neyra (IPBLN) alumnado del IES Montevives ( iesmontevives ).

Han conocido las unidades de Bioinformática 💻, Proteómica🧪, Microscopía 🔬, Animalario 🐁 y Prevención de Riesgos Laborales.

¡Muchas gracias por la visita!👀

¡Esperamos haber impulsado o incluso despertado algunas vocaciones científicas! 🤗

19/05/2026

Hoy en el Instituto de Parasitología y Biomedicina López-Neyra (IPBLN), Janet Martín Campos, ha realizado un seminario WIP.

Título: ‘Unraveling GAAA TREs: Mechanism, expansion and implications in renal cell carcinoma’.

Today at Instituto de Parasitología y Biomedicina López-Neyra (IPBLN), Janet Martín Campos gave a WIP seminar.

Title: ‘Unraveling GAAA TREs: Mechanism, expansion and implications in renal cell carcinoma’.

15/05/2026

Today, we hosted a seminar by Verónica I. Dorero at the IPBLN.

Title: ‘A Molecular Perspective of Celiac Disease: Linking Peptide Nanostructures, Innate Immunity, and the Microbiome’.

Gluten-related disorders (GRDs) are a group of diseases that occur after eating gluten, a protein found in wheat, barley, rye, and related grains. The most common GRDs are celiac disease (CD), wheat allergy (WA), and non-celiac gluten sensitivity (NCGS). These conditions involve abnormal immune responses to gluten-containing foods, which may lead to intestinal and systemic symptoms. In CD, gluten ingestion triggers an adaptive immune reaction characterized by T-cell activation and the generation of anti-tissue transglutaminase and anti-endomysial antibodies. This immune cascade causes damage to the small intestinal mucosa, often seen as villous atrophy and crypt hyperplasia. Patients can present with gastrointestinal symptoms such as diarrhea and malabsorption, but extraintestinal features like fatigue are also common, and in some cases, individuals may remain asymptomatic. CD is strongly associated with genetic predisposition, particularly the HLA-DQ2 and/or HLA-DQ8 alleles, but 30% of the general population carries these alleles; the worldwide prevalence of CD is 1%. Therefore, other environmental factors account for the onset of disease.
We are interested in the early stages of disease development, where the chemical behavior of gluten peptides and their interactions with the innate immune system and the microbiome may play a significant role. The aim is to develop therapeutic or nutritional approaches for prevention and treatment, grounded in a profound understanding of the biochemistry of gluten peptides. She has presented their latest results.

15/05/2026

Cientifiqueando con el Centro Albaysos ⚗️🧬 en una segunda sesión de .

¡¡Muchas gracias por la visita de ayer, equipo!! 👏😊

14/05/2026

¡Hoy estamos en la rueda de prensa del Pint Of Science Granada 2026!

En el siguiente enlace podéis ver todos los eventos que se van a realizar en Granada: https://pintofscience.es/events/granada/

Dirección

Avenida Del Conocimiento, 17
Granada
18016

Horario de Apertura

Lunes	08:00 - 20:00
Martes	08:00 - 20:00
Miércoles	08:00 - 20:00
Jueves	08:00 - 20:00
Viernes	08:00 - 20:00

Teléfono

+34647716821

Página web

http://www.ipb.csic.es/, http://canal.ipb.csic.es/

Notificaciones

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