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The Le Grand Lab

Name: The Le Grand Lab
Address: 105 Boulevard de l'hôpital, Paris, 75013, FR
Telephone: 667537091

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France
Paris
The Le Grand Lab

Our research aim at deciphering how extracellular signals regulate muscle stem cell fate.

Understanding the molecular mechanisms by which stem cells undergo cell fate decisions, especially self-renewal, is one of the fundamental goals of modern regenerative medicine. Reconstruction of the adult skeletal muscle tissue relies on a pool of resident committed muscle stem cells called the satellite cells. Our research aim at (1) deciphering how extracellular signals regulate normal satellit

e cell fate and (2) understanding the deregulations of these pathways in age-associated muscle atrophy and in neuro-muscular diseases.

20/04/2018

We publish our latest pre-print today on BioRxiv. Have a look and let us know what you think!

Adult tissue repair and regeneration require the activation of resident stem/progenitor cells that can self-renew and generate differentiated progeny. The regenerative capacity of skeletal muscle relies on muscle satellite cells (MuSCs) and their interplay with different cell types within the niche....

24/11/2017

Lorenzo Giordani represented the lab very well at the SFM meeting, and was awarded a prize for best presentation.

01/07/2017

We were at the Gordon Myogenesis Meeting a couple weeks ago. Great Science and good times with friends and colleagues.

09/03/2017

WE published our Rspo1 story in Cell Reports today. Cheers!

19/10/2016

Our latest paper is published today in the new journal Cell Discovery. Check out our work, it is the first ever demonstration of the control of a histone methyltransferase sub-cellular localization by an extracellular signaling pathway.

Cell Discovery, Published online: 18 October 2016; | doi:10.1038/celldisc.2016.37

24/09/2016

"1000 chercheurs dans les écoles" est une opération nationale de sensibilisation des publics scolaires organisée par l'AFM Téléthon et l'APBG

14/07/2016

Today we posted our latest manuscript on the pre-print server BiorXiv. This is the PhD work of Floriane Lacour, with great help from our lab engineer Elsa Vezin. Please share, discuss, and most of all wish us luck for getting published in a peer-reviewed journal soon. Any input on our work, through comments on the BioRxiv website, this page, our emails will be strongly appreciated.

Tissue regeneration requires the selective activation and repression of specific signaling pathways in stem cells. As such, the Wnt signaling pathways have been shown to control stem cell fate. In many cell types, the R-Spondin (Rspo) family of secreted proteins acts as potent activators of the cano...

09/07/2016

Our Grad Student Francesco Girardi won a PhD fellowship from the Université Pierre et Marie Curie. We are all happy for him.

20/06/2016

Our team member, Elsa Vezin, collaborated with Bruno Cadot's team and first author Valérie Vilmont, to help getting their paper published in Scientific reports. It is a great feeling to help!

http://www.nature.com/articles/srep27804

28/05/2016

Latest team picture, taken by our friend Bruno Cadot.

23/05/2016

https://media.giphy.com/media/JIX9t2j0ZTN9S/giphy.gif

05/05/2016

Visiting Hong Kong University of Science & Technology to work with my colleague Tom Cheung.
http://cheunglab.ust.hk

Adresse

105 Boulevard De L'hôpital
Paris
75013

Téléphone

667537091

Site Web

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