Isca Biochemicals

Isca Biochemicals Custom and catalogue peptides and biochemicals

30/03/2026

LA3IK is a novel Migration and Invasion Enhancer 1 (MIEN1) based hexapeptide, which is able to inhibit EGF mediated tumour progression in androgen independent, EGFR overexpressing PC3 prostate cancer cells. LA3IK selectively disrupts EGFR–ERBB2 heterodimerisation, reducing both phosphorylation of EGFR and downstream signaling through NF-κB, Src, and STAT3, leading to impaired EGF-driven migration and invasion while sparing proliferation. Transcriptomic analyses shows downregulation of the angiogenesis related genes ANGPTL4 and VEGFC. Crucially, LA3IK exhibits cancer selectivity, inhibiting EGF signaling in prostate tumours while preserving physiological EGFR function in healthy liver tissue.

LA3IK is a novel Migration and Invasion Enhancer 1 (MIEN1) based hexapeptide, which is able to inhibit EGF mediated tumour progression in androgen independent, EGFR overexpressing PC3 prostate cancer cells. LA3IK selectively disrupts EGFR–ERBB2 he

20/01/2026

WRPRFa is a peptide generated from a panel based on the ASIC3 modulating tetrapeptide RPRFa, by introducing changes at each each amino acid to understand their contribution to RPRFa activity. WRPRFa is the most potent ASIC3 activator to date, and has a specific intermolecular contact with the channel. WRPRFa stabilizes the activated state of ASIC3, increasing its sensitivity to protons and effectively removes acute desensitisation. ASIC3 can undergo tachyphylaxis at very acidic pH, which is accelerated by WRPRFa. WRPRFa is a selective and effective in vitro tool to study the interaction of RFamides and ASICs, and by extension gating mechanisms and the biophysics and biology of ASIC3.

WRPRFa is a peptide generated from a panel based on the ASIC3 modulating tetrapeptide RPRFa, by introducing changes at each each amino acid to understand their contribution to RPRFa activity. WRPRFa is the most potent ASIC3 activator to date, and has a s

02/12/2025

TAT (47-57) is a widely used and well characterised cell penetrating fragment of the HIV transactivator protein (TAT). TAT (47-57) is an arginine-rich TAT peptide which penetrates plasma membrane through passive diffusion to deliver a large variety of cargoes, from small particles to proteins, nucleic acids, and liposomes.

TAT (47-57) is a widely used and well characterised cell penetrating fragment of the HIV transactivator protein (TAT). TAT (47-57) is an arginine-rich TAT peptide which penetrates plasma membrane through passive diffusion to deliver a large variety of car

02/12/2025

Klotho-derived peptide 6 (KP6) binds to Wnt ligands and disrupts the engagement of Wnts with low density lipoprotein receptor-related protein 6 (LRD6), interrupting Wnt/β-catenin signaling. Klotho, an anti-aging protein, is kidney protective in Diabetic kidney disease (DKD). In vitro, KP6 prevents podocyte injury and inhibits β-catenin activation induced by high glucose without affecting Wnt expression. KP6 inhibits β-catenin activation in vivo and blocks the expression of its downstream target genes in glomerular podocytes and tubular epithelial cells. In DKD animal models, chronic infusion of KP6 reverses established proteinuria, attenuates glomerular hypertrophy, mitigates podocyte damage, and ameliorates glomerulosclerosis and interstitial fibrotic lesions.

Klotho-derived peptide 6 (KP6) binds to Wnt ligands and disrupts the engagement of Wnts with low density lipoprotein receptor-related protein 6 (LRD6), interrupting Wnt/β-catenin signaling. Klotho, an anti-aging protein, is kidney prote

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