01/04/2026
We are thrilled to announce the publication of our latest research article in Microchemical Journal entitled: “In situ microRaman spectroscopy as a screening tool for assessing human DNA preservation in ancient dental remains.” https://doi.org/10.1016/j.microc.2026.117446
https://www.iesl.forth.gr/en/situ-micro-raman-spectroscopy-fast-and-efficient-screening-tool-assessing-human-dna-preservation
https://phohs.iesl.forth.gr/raman-spectrometry-for-screening-ancient-teeth-for-dna/
Aggelos Philippidis, Victor Pinon, Demetrios Anglos
Photonics Laserart Forth, E-RIHS.gr
,
🔬 A Faster Way to Assess DNA Preservation in Ancient Teeth
Exciting new research introduces in situ micro-Raman spectroscopy as a rapid, non-invasive screening tool for evaluating human DNA preservation in ancient dental remains.
Supported by the Theodore Papazoglou FORTH Synergy Grant (Spectra-Gen), interdisciplinary teams from IESL (Photonics Laserart Forth), IMBB (Ancient DNA Lab), and FORTH-Institute of Computer Science analyzed a large collection of ancient teeth from excavations across Greece, spanning 8,000 years.
Published in Microchemical Journal, the study presents a straightforward spectrochemical approach that helps identify which samples are most likely to yield usable human DNA—before costly genetic analysis begins.
💡 How it works:
🔵Uses a compact, mobile micro-Raman spectrometer
🔵Analyzes intact teeth non-invasively, focusing on cementum
🔵Applies a molecular marker (Amide-to-Phosphate ratio, Am-I/P)
🔵Estimates protein (collagen) content relative to mineral matrix
📊 Results show a strong correlation between protein-rich dental tissue and successful recovery of endogenous human DNA—making this a powerful pre-screening method for archaeogenetics.
This approach can significantly streamline ancient DNA workflows, saving time, resources, and precious samples.
🔗View more: https://www.iesl.forth.gr/en/situ-micro-raman-spectroscopy-fast-and-efficient-screening-tool-assessing-human-dna-preservation