Jotbody Beyond Affinity

Jotbody Beyond Affinity Jotbody’s core team has profound expertise in two cutting-edge fields: nanobodies and extracellular vesicles.

What sets us apart is our exceptional ability to bring together the best of both worlds.

What if how you attach a nanobody to resin could dramatically boost binding capacity? A study published on Journal of Ch...
21/08/2025

What if how you attach a nanobody to resin could dramatically boost binding capacity? A study published on Journal of Chromatography demonstrates exactly that—using SpyCatcher/SpyTag chemistry to directionally orient nanobodies and enhance affinity resin performance....

Discover how SpyCatcher/SpyTag chemistry boosts affinity chromatography with oriented nanobody immobilization, delivering 3x higher binding capacity, stability, and efficiency.

A pioneering 2024 study in Nature Medicine suggests this is possible—using extracellular vesicles (EVs), microscopic mes...
19/08/2025

A pioneering 2024 study in Nature Medicine suggests this is possible—using extracellular vesicles (EVs), microscopic messengers released by cells, to carry tell-tale disease markers. Researchers found that two EV proteins—tau isoform ratios (3R/4R) and TDP 43—can accurately differentiate disorders like Frontotemporal Dementia (FTD), Amyotrophic Lateral Sclerosis (ALS), and Progressive Supranuclear Palsy (PSP) using just a blood sample!...

Explore how extracellular vesicles (EVs) from blood, carrying tau ratios and TDP-43 protein, could transform diagnosis of ALS, FTD, and PSP with high accuracy.

Introduction Burn patients face a high risk of sepsis, a life-threatening complication where early detection can save li...
12/08/2025

Introduction Burn patients face a high risk of sepsis, a life-threatening complication where early detection can save lives. Traditional diagnostic tools often fail to provide rapid, accurate results, especially during the early stages. A new study explores an innovative approach: using plasma-derived extracellular vesicles (EVs) analyzed by label-free Raman spectroscopy as biomarkers for sepsis in burn patients. Research Highlights Patient cohort…...

Discover how plasma-derived extracellular vesicles analyzed by label-free Raman spectroscopy can serve as early biomarkers for sepsis in burn patients, offering >90% diagnostic accuracy.

Researchers have developed NbHB1, a camelid-derived nanobody, to purify recombinant Hepatitis B surface antigen virus-li...
12/08/2025

Researchers have developed NbHB1, a camelid-derived nanobody, to purify recombinant Hepatitis B surface antigen virus-like particles (rHBsAg-VLPs) with large scale performance. This approach combines high specificity, excellent reusability, and scalability — all essential for modern vaccine production....

Nanobody NbHB1 resin achieves 96% purity, 81% recovery, and 25-cycle durability for scalable Hepatitis B vaccine purification.

Adeno‑associated virus serotype 8 (AAV8) is a gold standard viral vector in gene therapy. However, conventional antibody...
05/08/2025

Adeno‑associated virus serotype 8 (AAV8) is a gold standard viral vector in gene therapy. However, conventional antibody-based affinity columns suffer from low ligand density, poor stability, and high cost, which limit throughput and product quality. A new study presents a custom nanobody (Nb9) affinity resin that exhibits 9.12 mg ligand/mL, enables clean one-step AAV8 purification, and maintains over 70% binding capacity after 20 purification cycles, challenging the limitations of traditional resins. ...

Discover how nanobody-based affinity chromatography transforms AAV8 purification—delivering high ligand density, superior binding, and robust reusability beyond traditional antibody columns.

Are engineered extracellular vesicles (EVs) the new frontier for delivering genome editors and therapeutic payloads? In...
05/08/2025

Are engineered extracellular vesicles (EVs) the new frontier for delivering genome editors and therapeutic payloads? In a landmark 2025 Nature Communications study led by Samir EL Andaloussi et al., researchers engineered EVs to deliver multimodal cargo—including CRISPR/Cas9 RNPs and Cre recombinase—with remarkable in vitro and in vivo efficiency....

Learn how a new EV engineering platform enables high efficiency delivery of genome editors and multimodal therapeutics, overcoming challenges of endosomal escape and cargo stability.

Small ubiquitin-related modifier (SUMO) fusion tags facilitate protein expression and stability, but purifying SUMO-tagg...
29/07/2025

Small ubiquitin-related modifier (SUMO) fusion tags facilitate protein expression and stability, but purifying SUMO-tagged proteins is often plagued by inefficiencies: unstable antibody columns, low throughput, and limited reusability. A research paper introduced VS2 resin, a camelid VHH nanobody-based chromatography resin targeting SUMO. It combines high affinity, wide specificity, and durable performance, enabling efficient one-step purification—delivering cleaner, faster, and more sustainable protein workflows than conventional antibody resins....

Discover VS2, a camelid VHH nanobody based chromatography resin that delivers 16.23 mg/mL binding, specificity for eight SUMO fusions, and retains over 80% capacity after 25 NaOH cycles—a superior alternative to antibody columns.

Could engineering dopamine onto EV surfaces offer a breakthrough for Parkinson’s Disease? A recent 2024 Journal of Extra...
29/07/2025

Could engineering dopamine onto EV surfaces offer a breakthrough for Parkinson’s Disease? A recent 2024 Journal of Extracellular Vesicles study by Dong-Gyu Jo demonstrates that dopamine-conjugated EVs (termed Dopa‑EVs) selectively target dopaminergic neurons, induce protective autophagy, and reverse neurodegeneration in models of Parkinson’s Disease....

Explore how dopamine-conjugated EVs engineered for targeted dopaminergic neuron delivery induce autophagy, rescue neuronal loss, and improve behavior in Parkinson’s models—demonstrating breakthrough surface engineering.

A Molecular Therapy review by Fatah Kashanchi reveals EVs as versatile, natural nanoparticles that transport RNAs and ev...
22/07/2025

A Molecular Therapy review by Fatah Kashanchi reveals EVs as versatile, natural nanoparticles that transport RNAs and even CRISPR guides—protecting cargo integrity and targeting challenging tissues like the brain and tumors....

Explore how RNA-loaded extracellular vesicles (EVs) are emerging as safer, more targeted gene therapy vectors—delivering miRNA, siRNA, mRNA, and CRISPR guides across biological barriers with low toxicity.

Aflatoxin B₁ (AFB₁), a potent carcinogenic mycotoxin, frequently contaminates staples like corn and peanuts worldwide. T...
22/07/2025

Aflatoxin B₁ (AFB₁), a potent carcinogenic mycotoxin, frequently contaminates staples like corn and peanuts worldwide. Traditional rapid immunochromatographic strips (ICTS) often fail to detect trace levels needed for food safety. In July 2025, a research paper from International Journal of Biological Macromolecules introduced a nanobody-based fluorescent ICTS merging high-affinity G8 nanobodies with aggregate quantum microspheres (AQMs). This novel strip achieves an ultra-sensitive limit of detection (LOD) of 0.03 ng/mL and delivers results in just 8 minutes, breaking performance records for on-site toxin detection....

Aflatoxin B₁ (AFB₁), a potent carcinogenic mycotoxin, frequently contaminates staples like corn and peanuts worldwide. Traditional rapid immunochromatographic strips (ICTS) often fail to detect trace levels needed for food safety. In July 2025, a research paper from International Journal of ...

Bladder cancer affects over half a million people annually worldwide, and current detection methods—cystoscopy and urine...
15/07/2025

Bladder cancer affects over half a million people annually worldwide, and current detection methods—cystoscopy and urine assays—are either invasive or low in accuracy. In 2025, a research paper on Applied Bio materials reported a new lateral flow immunoassay (LFIA) using nanobodies (VHH) coupled with gold nanoparticle clusters (AuNP) to rapidly and precisely detect the urinary biomarker survivin, revolutionizing early and noninvasive bladder cancer diagnostics....

Discover the new nanobody-based AuNP cluster LFIA for rapid, accurate bladder cancer biomarker detection. Achieving an LOD of 3.90 ng/mL, it promises noninvasive, affordable diagnostics.

A 2024 study by Migara Jayasinghe et al. reveals that Engineered EVs significantly improved immune activation, resulting...
15/07/2025

A 2024 study by Migara Jayasinghe et al. reveals that Engineered EVs significantly improved immune activation, resulting in tumor killing....

Explore how 2024 Molecular Therapy research shows ligand displaying EVs achieve over 90% tumor cell killing, safer liver profiles, and potent ex vivo T cell cytotoxicity—ushering in safer, precise cancer immunotherapy.

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