12/04/2016
In our efforts to promote the COMU , we do collect information about it from all over
the word and forward it to Scientists working for multinational companies
COMU is rather stable as a solid. Importantly, take into consideration that the degradation products of COMU will be totally inactive.
The degradation compound corresponding to the uranium part is the urea and the urea will not react with the amine.
The use of all uronium salts came with a potential side reaction, the formation of the guanidino compound.
This is a competitive reaction
COMU can react with incoming protected amino acid to give the Oxyma active ester and can react with the amine function to give the guanidino.
For this reason and in solid-phase, we always propose to use a slight defect of uronium salts, to avoid the reaction with the free amine.
In solution, it is also very recommendable to run a preactivation of the incoming amino acid in order to consume all the uronium salt before to enter in touch with the free amine.
Regards.
YOAV
