16/09/2025
Lumefantrine API (Active Pharmaceutical Ingredient)
Product Name: Lumefantrine
CAS No.: 82186-77-4
Molecular Formula: C₃₀H₃₂Cl₃NO
Molecular Weight: 528.9 g/mol
Description:
Lumefantrine is a highly effective antimalarial active pharmaceutical ingredient (API) belonging to the aryl amino alcohol class of antimalarials. It is commonly used in combination therapy with Artemether (Artemether + Lumefantrine) for the treatment of acute uncomplicated Plasmodium falciparum malaria.
Mechanism of Action:
Lumefantrine interferes with the polymerization of heme inside the malaria parasite, leading to accumulation of toxic heme and parasite death.
Key Features:
Broad-spectrum efficacy against multidrug-resistant Plasmodium falciparum.
Used in WHO-recommended Artemisinin-based Combination Therapy (ACT).
High safety profile when combined with Artemether.
Widely supplied for formulation into tablets/capsules.
Available in bulk quantities.
📌 Manufacturer & Supplier:
AVIGHNA CHEMICAL PRIVATE LIMITED
Ahmedabad, India
📧 [email protected]
🌐 www.avighnachemical.com