19/06/2025
๐ก๐ผ๐ ๐ท๐๐๐ โ๐ป๐ผ๐ป-๐ถ๐ป๐๐ฎ๐๐ถ๐๐ฒ.โ ๐ง๐ต๐ถ๐ ๐ณ๐ถ๐ฒ๐น๐ฑ ๐ถ๐ ๐ฟ๐ฎ๐ฝ๐ถ๐ฑ๐น๐ ๐ฒ๐๐ผ๐น๐๐ถ๐ป๐ด, ๐ด๐น๐ผ๐ฏ๐ฎ๐น๐น๐ ๐ฐ๐ผ๐ป๐ป๐ฒ๐ฐ๐๐ฒ๐ฑ, ๐ฎ๐ป๐ฑ ๐ฐ๐น๐ถ๐ป๐ถ๐ฐ๐ฎ๐น๐น๐ ๐ฎ๐บ๐ฏ๐ถ๐๐ถ๐ผ๐๐.
A new paper in Frontiers in Neuroscience maps 20 years of global research on Transcranial Ultrasound Stimulation (TUS), a promising tool for non-invasive neuromodulation, from Alzheimer's therapy to brain-computer interface (BCI) integration.
The analysis covers 577 papers (2004โ2024), uncovering trends in output, key institutions, collaboration patterns, and the shifting landscape of clinical and mechanistic TUS studies.
๐๐ฒ๐ ๐๐ถ๐ด๐ต๐น๐ถ๐ด๐ต๐๐:
๐ฏ๐๐น๐ผ๐ฏ๐ฎ๐น ๐ฆ๐ฐ๐ฎ๐น๐ฒ: TUS research has surged, especially after 2013. The U.S., China, and Germany lead, with Harvard and the University of Toronto as institutional hubs.
๐ฏ๐ก๐ฒ๐๐ฟ๐ผ๐ฑ๐ฒ๐ด๐ฒ๐ป๐ฒ๐ฟ๐ฎ๐๐ถ๐๐ฒ ๐๐ผ๐ฐ๐๐: Studies show TUS can improve memory and motor function in Alzheimerโs and Parkinsonโs, even without opening the blood-brain barrier.
๐ฏ๐๐บ๐ฒ๐ฟ๐ด๐ถ๐ป๐ด ๐ง๐ต๐ฒ๐บ๐ฒ๐: Keyword bursts spotlight โfunctional connectivity,โ โhuman motor cortex,โ and โfocused ultrasoundโ as rising themes.
๐ฏ๐๐ป๐ด๐ถ๐ป๐ฒ๐ฒ๐ฟ๐ถ๐ป๐ด ๐๐ต๐ฎ๐น๐น๐ฒ๐ป๐ด๐ฒ๐: Safety remains top priority, with concerns around skull variability, off-target effects, and long-term impact still under investigation.
๐ฏ๐๐ ๐
๐ง๐จ๐ฆ: AI-enhanced systems are being explored for personalized targeting, stimulation timing, and real-time feedback via EEG, fMRI, and fNIRS.
๐ฏ ๐๐ฟ๐ผ๐บ ๐ง๐ต๐ฒ๐ผ๐ฟ๐ ๐๐ผ ๐๐น๐ถ๐ป๐ถ๐ฐ: Most studies are still preclinical. Multi-center trials and standardized TUS parameters are key to translation and regulatory acceptance.
Transcranial Ultrasound is no longer fringe; itโs becoming one of the most scalable, precise, and AI-compatible tools in the neurotech stack.
Authors: Jianfeng Wang, Yihui Wang, and Shaoqiang Qin
๐ Read more: https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1595061/full