Sapien Biosciences

25/03/2022

Dr. Jugnu Jain shares her thoughts on entrepreneurship with the T-Hub Hyderabad

03/02/2022

Research Associate
Job Location : Hyderabad
Biobanking data Base development and Project ex*****on

03/02/2022

Research Associate / Senior Research Associate
Job Location : Hyderabad

30/12/2021

Landscape of Kinase gene fusions in cancers

https://sapienbio.co.in/?p=5625

Tyrosine kinases such as ALK, RET and ROS1 are often activated by translocations or chromosomal rearrangements that result in increased oncogenic activity and are attractive candidates for targeted therapy. In our , we have identified many patient samples harbouring ALK, RET and ROS1 rearrangements by NGS.

FDA approved drugs such as Crizotinib (Xalkori, ), Ceritinib (Zykadia, ), and Alectinib (Alecensa, ) that target the kinase activity of ALK; Pralsetinib (Gavreto, Roche) targeting RET fusions in NSCLC; Entrectinib (Rozlytrek, Roche) for ROS1+ metastatic NSCLCs, and novel drugs in offer promising therapeutic approaches for not just lung but also breast, colorectal and other solid tumours.

Landscape of Kinase gene fusions in cancers December 30, 2021/0 Comments/in Blog /by admin Tyrosine kinases such as ALK, RET and ROS1 are often activated by translocations or chromosomal rearrangements that result in increased oncogenic activity and are attractive candidates for targeted therapy. In...

27/11/2021

ALK targeted therapy for lung cancer: Integration of NGS genome profiling in management of ALK-mutated NSCLCs in India

https://sapienbio.co.in/?p=5618

The NGS genotyping of our NSCLC cases using ThermoFisher’s Oncomine panel identified 8 genetic variants in the ALK gene in 9 cases (16.67%), some of which, such as G1202R and S1206Y surprisingly confer resistance to treatment, but demonstrate sensitivity to second-generation ALK inhibitors such as and , which are currently approved for the treatment of metastatic lung cancers (Sullivan I et al., Ther Adv Med Oncol 2016).

Integration of NGS genetic profiling of tumour samples could play a beneficial role in the management of ALK mutated NSCLCs in India by helping identify the best targeted therapy among Brigatinib, Ceritinib and Crizotinib upfront, based on the mutational profile.

Cancer Research Foundation
Resources:
https://www.alkpositive.org/
https://www.cancer.org/cancer/lung-cancer/treating-non-small-cell/targeted-therapies.html
https://www.lung.org/lung-health-diseases/lung-disease-lookup/lung-cancer/symptoms-diagnosis/biomarker-testing/alk-lung-cancer

ALK targeted therapy for lung cancer: Integration of NGS genome profiling in management of ALK-mutated NSCLCs in India November 27, 2021/0 Comments/in Blog /by admin The NGS genotyping of our NSCLC cases using ThermoFisher’s Oncomine panel identified 8 genetic variants in the ALK gene in 9 cases (...

18/11/2021

Building Genotype-Phenotype Correlation Data for Lung Cancer in India

https://sapienbio.co.in/?p=5604

Sapien is curating real world data for the lung cancer cases in the biobank. While 90-95% of our NSCLC samples are biopsies which are mostly exhausted in patient diagnosis and subsequent clinical evaluation, the resection samples are being characterized genomically in Oncomine panel to correlate the demographic, diagnostic, treatment and outcomes data with genetic mutations.
The first of such 48 cases showed a very high number of SNVs (479), CNVs (5), Fusions (6) and indels (14). Highest number of mutations were observed in KEAP1 (43.2% of all mutations), followed by STK11 (31.5% of all mutations).

Building Genotype-Phenotype Correlation Data for Lung Cancer in India November 18, 2021/0 Comments/in Blog /by admin Sapien is curating real world data for the lung cancer cases in the biobank. While 90-95% of our NSCLC samples are biopsies which are mostly exhausted in patient diagnosis and subsequ...

13/10/2021

KRAS mutations in Breast cancer may be treatable

https://sapienbio.co.in/?p=5596

For decades, mutations in have been known to cause cancers in multiple organs and the gene KRAS itself was considered ‘undruggable’. Of the many mutations, KRAS-G12C is known to occur in nearly 13% of cases. There were no known treatments that can target KRAS-G12C mutation until recently. May 2021 heralded the of Sotorasib, granted to , for treatment of with the G12C mutation in KRAS. Exciting results showed a reduction in tumour burden in more than 37% of the trial participants. This paves the way for testing the efficacy of the drug in multiple other cancers harbouring this driver mutation.
Our data identified nearly 7.8% of breast cancer samples bearing the KRAS-G12C mutation, bringing hope of this to people with .

KRAS mutations in Breast cancer may be treatable October 13, 2021/0 Comments/in Blog /by adminFor decades, mutations in have been known to cause cancers in multiple organs and the gene KRAS itself was considered ‘undruggable’. Of the many mutations, KRAS-G12C is known to occur in nearly 13...

31/07/2021

1st August – World Lung Cancer Day – Focusing on Treatment for Lung Cancer
https://sapienbio.co.in/?p=5588

In recognition of , It is important for everyone to learn about the for Lung cancer along with the importance of through and timely treatment to decrease .

In cancer care, different types of doctors often work together to create a patient’s overall treatment plan that combines different types of treatments. This is called a multidisciplinary team.

There are 5 main treatment options : i) Surgery, ii) , iii) , iv) Targeted therapy v)

includes , Wedge resection, Segmentectomy, .

is the use of to destroy cancer cells, usually by keeping the cancer cells from growing, dividing, and making more cells. It has been shown to improve both the length and quality of life for people with lung cancer of all stages. Targeted therapy is a that targets the cancer’s specific genes, proteins, or the tissue environment that contributes to cancer growth and survival. This type of treatment blocks the growth and spread of cancer cells and limits damage to healthy cells. Immunotherapy, also called biologic therapy, is designed to boost the body's natural defenses to fight the cancer. It uses material made either by the body or in a laboratory to improve, target, or restore immune system function.

1st August – World Lung Cancer Day – Focusing on Treatment for Lung Cancer July 31, 2021/0 Comments/in Blog /by adminIn recognition of , It is important for everyone to learn about the for Lung cancer along with the importance of through ...

14/07/2021

Prostate cancer slide 1 – showcase of Prostate cancer inventory at Sapien
https://sapienbio.co.in/?p=5578
Prostate cancer is the most common gender specific cancer. Prostate is the second leading site of cancer among males in large Indian cities like Delhi, Kolkata, Pune and Thiruvananthapuram, third leading site of cancer in cities like Bangalore and Mumbai. According to the Indian Council of Medical Research (ICMR) and various state cancer registries, prostate cancer is the second most common form of cancer among Indian males with an incidence rate of nine to 10 per 1,00,000 population, which is higher than Africa and other parts of Asia . Almost 75% of men diagnosed with prostatic cancer are 65 or older, but the tumors can be seen in younger adults and even in children and adolescents. Hence regular screening above the age of 60 must be done for the early signs. Early screening is the best possible way to prevent and to treat the cancer before it spreads. Screening is done by checking PSA levels, and/or MRI, Ultrasound or biopsy along with physical examination.

showcase of Prostate cancer inventory at Sapien July 14, 2021/0 Comments/in Blog /by adminProstate cancer is the most common gender specific cancer. Prostate is the second leading site of cancer among males in large Indian cities like Delhi, Kolkata, Pune and Thiruvananthapuram, third leading site o...

07/06/2021

Pediatric gliomas
https://sapienbio.co.in/?p=5565
Individuals below the age of 18 years are susceptible to and so is paramount. Many different treatment options are available including , , and surgery based on the type of and disease severity. Excellent follow up care both by family, clinics and organizations such as Pediatric Brain Tumor Consortium, Pediatric Brain Tumor Foundation, and others will restore a healthy life to those affected.

American Brain Tumor Association; https://www.linkedin.com/company/theabta/
Children's Brain Tumor Foundation; https://www.linkedin.com/company/cbtf/
International Brain Tumour Alliance; https://www.linkedin.com/company/international-brain-tumour-alliance/about/
A Kids' Brain Tumor Cure Foundation (PLGA Foundation); https://www.linkedin.com/company/a-kids'-brain-tumor-cure/about/
National Brain Tumor Society; https://www.linkedin.com/company/national-brain-tumor-society/
Pediatric Brain Tumor Foundation; https://www.linkedin.com/company/pediatric-brain-tumor-foundation/
ABC2 (Accelerate Brain Cancer Cure); https://www.linkedin.com/company/accelerate-brain-cancer-cure/

Pediatric gliomas June 7, 2021/0 Comments/in Blog /by adminIndividuals below the age of 18 years are susceptible to and so is paramount. Many different treatment options are available including , , and surgery based on the type of....

26/05/2021

Mutations and mutation analysis in cancer are very useful for specific that target the and spare normal cells. , especially is a well-established option for . With novel therapies and being discovered with increasing frequency, the treatment options available for combating cancers are increasingly dependent on . With adequate and along with a helping hand, defeating this deadly disease has never looked more promising.

Targeted therapy in Gliomas based on genetic screening ? May 26, 2021/0 Comments/in Blog /by adminMutations and mutation analysis in cancer are very useful for specific that target the and spare normal cells. , especially is a well-establish...