長瀬研究室 - 創薬化学

Our research object is to create drugs for acting the central nervous system. In particular, the orexin receptor agonists are the most attractive and significant goal, because orexin receptor is related with sleep/wake switching, eating and emotion behavior and we have no specific drugs. Creation of non-peptide small molecules would lead to be treatment for trouble sleeping, narcolepsy, and also b

e useful in resolving the mechanism of eating behavior, depressant and anxiety symptoms. Also, we continue our efforts to create first-in-class drugs acting on central nervous system, such as cancer and neuropathic pain, Parkinson’s disease, schizophrenia, and epilepsy via opioid research, which is our long-term research area. Our fundamental discipline is Medicinal Chemistry which is the only one domain (group) in IIIS. Medicinal chemistry is an interdisciplinary science, because it rest on not only organic synthetic chemistry, but medical science, pharmaceutical science, biochemistry, molecular biology, pharmacology, ADME study and drug formulation. We expect that you would grow into an excellent medicinal chemist and offer first-in-class drugs to patients in the future.