23/10/2024
⍰ What is an immune synapse and why is it relevant for cell therapy?
(A bit of micro-learning for your Wednesday, chopped up into small pieces of digestible information.)
An immune synapse is the interface between an antigen-presenting cell or target cell and a lymphocyte or natural killer cell.
It’s formed in a highly stable, organized manner.
This interface includes T cell receptor (TCR) clustering, checkpoint or costimulatory receptor binding, cell-cell adhesion proteins, and more.
Proper formation of the immune synapse between a cancer cell and an effector cell is crucial.
It initiates immune cell activation, sustains proliferation, and increases cytokine secretion against cancer cells.
The organization of the TCR and molecules at the binding site impacts immune cell function.
And investigating the synaptic structure helps researchers understand the mechanism of action.
This leads to better predictions of immunotherapy efficacy.
👉 Learn about immune synapses and more on our cell avidity resource page on lumicks.com
