Małopolskie Centrum Biotechnologii

Małopolskie Centrum Biotechnologii MCB is an international post-graduate research institute of the Jagiellonian University. nutrigenomiki).

Małopolskie Centrum Biotechnologii (MCB) powstało jako projekt mający na celu utworzenie interdyscyplinarnego ośrodka badawczego umożliwiającego wykonywanie kompleksowych badań na różnych poziomach funkcjonowania organizmu. Małopolskie Centrum Biotechnologii tworzy 6 ośrodków o zróżnicowanych, ale komplementarnych tematykach badawczych oraz 5 laboratoriów niezależnych grup badawczych. Obszary dzia

łalności naukowej MCB (biotechnologia, choroby zakaźne, bezpieczeństwo żywności, biologia strukturalna, nutrigenomika, neurobiologia oraz bioinformatyka) wchodzą w skład grupy tematycznej Bio, stanowiącej jeden z czterech „strategicznych obszarów tematycznych badań i rozwoju technologii w Polsce". Budowa nowych, unikalnych w skali światowej specjalistycznych laboratoriów pozwalających m.in. na hodowlę komórek skóry dla celów terapeutycznych (przeszczepy autologiczne), czy badań nad patogenami 3 klasy bezpieczeństwa biologicznego w niewątpliwy sposób przyczyni się do poprawy jakości badań i warunków pracy naukowców. Nowoczesna aparatura pozwala na prowadzenie badań w nowych obszarach nauki, które dotychczas, ze względu na brak wyposażenia były niedostępne (np. badania neuroadaptowalnych technologii czy opracowywanie nowoczesnych metod bioremediacji uwzględniających zastosowanie mikroorganizmów glebowych). Ponadto, budowa i wyposażenie nowych pomieszczeń laboratoryjnych przyczynią się do jakościowej poprawy realizowanych prac badawczych, poszerzenia zakresu prowadzonych projektów we współpracy z przemysłem farmaceutycznym, biotechnologicznym, przetwórstwa żywności, medycyny i ochrony zdrowia (powstający Ośrodek Badań Genetycznych i Nutrigenomiki stanie się filarem NuGO – europejskiej sieci doskonałości ds. Mamy nadziję, że działalność Małopolskiego Centrum Biotechnologii przyczyni się do równiesz do zwiększenia wykorzystania efektów prac B+R w przedsiębiorstwach. Podsumowowując, MCB jest odpowiedzią na zapotrzebowanie trzech grup społecznych: przedsiębiorców poprzez otwarcie możliwości współpracy i komercjalizacji badań, naukowców przez stworzenie warunków pracy na wysokiej klasy aparaturze badawczej a także społeczności lokalnej poprzez dostęp do najnowocześniejszych metod badawczych i diagnostycznych. Rzeczowa realizacja projektu rozpoczęła się w 2009 roku i zostanie zakończona w 2014 roku. Całkowity koszt projektu szacowany jest na 91 861 829,53 PLN.

 What happens when you slow down one of the most fundamental processes in our cells? 🧬🚦For a long time, scientists belie...
28/05/2026



What happens when you slow down one of the most fundamental processes in our cells? 🧬🚦

For a long time, scientists believed that DNA replication and transcription had to move at a coordinated pace to prevent DNA damage and genome instability. But a new study in Science Advances completely flips this assumption!

By slowing down transcription, researchers found that DNA replication didn't suffer—it actually got faster and remained perfectly stable. Even more surprising? Slower transcription helped stem cells rewire themselves into a naive pluripotent state, meaning transcription speed could be a key dial for controlling cell identity.

This breakthrough research was led by Dr. María Gómez's team at Universidad Autónoma de Madrid, with the input of our scientists: dr. hab. Magdalena Masłoń and PhD student Shraddha Shinde.

Congrats to all authors!

The research done in MCB was funded by Narodowe Centrum Nauki and NAWA Narodowa Agencja Wymiany Akademickiej.

Uniwersytet Jagielloński

Check the full paper: https://www.science.org/doi/10.1126/sciadv.adz6211

Fantastic news from our neighbors at WBBiB UJ! 🎉 Wydział Biochemii, Biofizyki i Biotechnologii - Uniwersytet Jagiellońsk...
28/05/2026

Fantastic news from our neighbors at WBBiB UJ! 🎉 Wydział Biochemii, Biofizyki i Biotechnologii - Uniwersytet Jagielloński
They have just opened a brand-new Creative Space at the Library of Natural Sciences, transforming traditional reading rooms into modern coworking zones and cozy relaxation areas. 🚀

🤝 The best part? We can use it too!
Since we share the campus, this space is open to the MCB community as well! It’s the perfect spot for your next project meeting, a change of scenery for laptop work, or a coffee break to network with fellow researchers.

Big congratulations to Prof. Jonathan Heddle and the team at MCB! 🍾Their paper, "Designed, Programmable Protein Cages Ut...
26/05/2026

Big congratulations to Prof. Jonathan Heddle and the team at MCB! 🍾

Their paper, "Designed, Programmable Protein Cages Utilizing Diverse Metal Coordination Geometries Show Reversible, pH‐Dependent Assembly" published in Macromolecular Rapid Communications, has ranked in the top 10% of most-viewed papers published by the journal in 2024! 📊✨

Fantastic work by our researchers on pushing the boundaries of programmable protein design! 👏🧬

Check the paper: https://onlinelibrary.wiley.com/doi/epdf/10.1002/marc.202400712

MCB Summer School 2026! 🎉Over the last two days at Radocza Park, we truly lived up to our theme: "From Discovery to Impa...
22/05/2026

MCB Summer School 2026! 🎉
Over the last two days at Radocza Park, we truly lived up to our theme: "From Discovery to Impact: Translating Life Sciences." It was an incredibly intense and inspiring time packed with groundbreaking science, brilliant keynotes, fantastic student presentations, and some well-deserved networking by the traditional bonfire and PhDJ party! 🔥🔬

A massive thank you to our brilliant participants for their energy and ideas, to the organizers Magda Masłoń, Monika Jakubowska Mateusz Sikora and their teams) for working tirelessly behind the scenes, and to MCB and all our sponsors: Lenovo, SmartLab, GENOMED S.A. (Poland), TK Biotech Sp. z o.o., Lab-JOT® Ltd. Sp.z o.o., I.C.LabM , A&A Biotechnology and Dioscuri Centre for Moddeling of Posttranslational Modifications for making this event possible. You all made this edition unforgettable!

📸 Stay tuned! A full photo gallery and a detailed recap of the scientific highlights and award winners are coming soon.

 How do bacteria make vitamin B2 so efficiently without internal organs? They build their own nanoscale "cages"! An inte...
19/05/2026


How do bacteria make vitamin B2 so efficiently without internal organs? They build their own nanoscale "cages"! An international research team led by dr. hab. Yusuke Azuma has just published a breakthrough in Nature Communications, revealing a secret biological mechanism.

Using advanced cryo-electron microscopy at the Synchrotron SOLARIS, researchers captured a rare, "open" intermediate cage for the very first time. Unlike other biological systems, the cargo enzymes anchor right where the shell building blocks connect. They keep the shell partially open until enough cargo is loaded, and then a molecular lock clicks the final piece into place to trap the cargo inside.

Since bacteria lack membrane-bound organelles, they use these elegant protein cages to compartmentalize and organize complex biochemical processes. This remarkable precision provides scientists with a brand-new blueprint for building biomimetic nanoreactors, which can be used to engineer drugs and other high-value chemicals in the future.

Congratulations to the collaborative team from MCB, the Helsinki Institute of Life Science (HiLIFE) Science, and the Institute for Molecular Science (Japan) for unlocking this 40-year-old molecular mystery! 👏

Check the full text paper: https://www.nature.com/articles/s41467-026-73260-4
Check the full press release: https://mcb.uj.edu.pl/aktualnosci/-/journal_content/56_INSTANCE_wWpAonkKsToI/150912362/160956011

fot. Arkadiusz Dobosz

🎉 Huge congratulations to our PhD student Igor Kaczmarczyk from the Max Planck Research Group at MCB! 👏Igor has been awa...
15/05/2026

🎉 Huge congratulations to our PhD student Igor Kaczmarczyk from the Max Planck Research Group at MCB! 👏

Igor has been awarded the prestigious START scholarship by the FNP Foundation for Polish Science. This highly competitive annual award recognizes the most talented young researchers under the age of 30 who have already made significant contributions to their fields. 🔬✨

With 100 scholarships awarded nationwide, we are incredibly proud to see our brilliant minds recognized at the highest level. We are thrilled that every year, young scientists from MCB continue to join the prestigious ranks of START laureates! 🌟

Keep shining and pushing the boundaries of science, Igor! 🚀

Fundacja na rzecz Nauki Polskiej
Uniwersytet Jagielloński
Szkoła Doktorska Nauk Ścisłych i Przyrodniczych UJ

We are thrilled to announce that four of our brilliant researchers have been nominated for the Top 100 Women in Biotech ...
14/05/2026

We are thrilled to announce that four of our brilliant researchers have been nominated for the Top 100 Women in Biotech in Poland list! 🧬✨

This prestigious ranking, organized by the Perspektywy Women in Tech Educational Foundation, celebrates the visionary women driving innovation and excellence across STEM.

Please join us in celebrating our nominees:
in the category "Rising Stars in Biotech":
💫Dr Aleksandra Synowiec
💫Marta Walczak
💫Agata Szymanek
and in the category "Biotech Entrepreneurs"
💫Dr Kinga Zielińska

The final Top 10 will be revealed during the ceremonial gala on June 10, selected by a distinguished jury of international experts.

We are incredibly proud to see the talent from the Małopolska Centre of Biotechnology recognized on such a significant stage. Congratulations to all the nominees for their dedication to shaping the future of science! 👏🔬

🚀 Kraków powers up the future of AI!The Gaia AI Factory has officially launched, marking the start of Poland’s largest A...
12/05/2026

🚀 Kraków powers up the future of AI!

The Gaia AI Factory has officially launched, marking the start of Poland’s largest AI infrastructure project. While led by Academic Computer Centre CYFRONET AGH, a key role is played by the Małopolska Centre of Biotechnology (MCB) of the Jagiellonian University.

The MCB UJ team, led by dr hab. Paweł P. Łabaj, dr Mateusz Sikora, and mgr Wojciech Pilch, is deeply involved in developing the project's core solutions. They are leveraging the project's massive computing power to advance structural biology, bioinformatics, and computational medicine.

From predicting protein structures and designing new drugs to modeling the exposome and analyzing epidemiological threats, MCB’s expertise is turning raw data into life-saving medical innovations.

This collaboration solidifies Kraków’s position as a premier European hub for AI and biotechnology.

Photo source: dziennikpolski24.pl

 🔬 We are proud to share that a successful collaboration between Molecure, the Medical University of Warsaw (MUW), and o...
11/05/2026


🔬 We are proud to share that a successful collaboration between Molecure, the Medical University of Warsaw (MUW), and our Structural Biology Core Facility (SBCF) has been published in the Journal of Medicinal Chemistry.

Our team provided critical structural insights through macromolecular crystallography, helping to optimize the potent USP7 inhibitor OAT-4828. This compound shows great promise in enhancing T-cell killing capacity and demonstrates significant antileukemic activity.

Congratulations!

Uniwersytet Jagielloński

Check the full text: https://doi.org/10.1021/acs.jmedchem.6c00407

 Antibiotics are losing their edge, but nature has a backup. Researchers led by dr hab. Rafał Mostowy and Prof. Zuzanna ...
06/05/2026


Antibiotics are losing their edge, but nature has a backup. Researchers led by dr hab. Rafał Mostowy and Prof. Zuzanna Drulis-Kawa have used "virus archaeology" and machine learning to uncover how bacteriophages—viruses that hunt bacteria—breach the defenses of deadly pathogens like Klebsiella pneumoniae.

Previously, we thought phages only destroyed bacterial "armor" using brute-force enzymes. This study, published in PLOS Biology, reveals a much stealthier tactic: some phages act as "trimmers," quietly snipping away tiny chemical hooks on the bacterium's surface to gain entry.

"Some viruses demolish this wall, while others – as we discovered – quietly remove the hooks." — Prof. Rafał Mostowy

This discovery expands our toolkit for fighting antibiotic resistance. By mastering these viral "keys," scientists can better design precision therapies to neutralize superbugs that have evolved past traditional medicine.

Congratulations to the Authors!

The research was funded by the Narodowe Centrum Nauki, NAWA Narodowa Agencja Wymiany Akademickiej and European Molecular Biology Organisation.

This story is also presented in another form - we invite you to check out the comic below. The creator of the comic is the illustrator Paweł Piechnik.

Check the article full text: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003716

Check the full press-release: https://mcb.uj.edu.pl/en_GB/aktualnosci/-/journal_content/56_INSTANCE_wWpAonkKsToI/150912362/160845356

We are proud to announce that Dr. Mateusz Sikora, leader of the Dioscuri Centre at the MCB, has reached a major mileston...
27/04/2026

We are proud to announce that Dr. Mateusz Sikora, leader of the Dioscuri Centre at the MCB, has reached a major milestone in the commercialization of his research. Following a high-stakes bootcamp and a successful pitch before an expert jury, Dr. Sikora’s project—GlycoDYNAMIX—has been selected to advance to the Exploration Phase of the prestigious MAX!mize incubation program.

Developed in collaboration with Dr. Balázs Fábián from the Max Planck Institute of Biophysics, the project is now entering a critical stage where scientific excellence meets business strategy. Throughout this phase, Dr. Sikora will work alongside mentors and industry experts to refine the project's business model, evaluate potential market applications, and shape the future development of this innovative research.

"While there is still a lot of work ahead of us, participation in the MAX!mize program has already helped us clarify our development path and better define the application of our research," says Dr. Mateusz Sikora.

The MAX!mize program, led by Max Planck Innovation, is designed to bridge the gap between world-class research and entrepreneurship. We are incredibly excited to see Dr. Sikora represent the Małopolska Centre of Biotechnology on this international stage of innovation. 👏🧬

Uniwersytet Jagielloński

Adres

Ulica Gronostajowa 7a
Kraków
30-387

Godziny Otwarcia

Poniedziałek 09:00 - 17:00
Wtorek 09:00 - 17:00
Środa 09:00 - 17:00
Czwartek 09:00 - 17:00
Piątek 09:00 - 17:00
Sobota 09:00 - 17:00

Telefon

12 664 5369

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