Mitochondrial Toxicology and Experimental Therapeutics

Mitochondrial Toxicology and Experimental Therapeutics This page aims to publicize the activities of the MitoXT research group .UC

Areas of focus
-Failure of energy metabolism on drug and stress-induced cardiovascular injury.
-Role of bioenergetic failure in cardiovascular disease initiation and progression.
-Modulation of energy metabolism function and cross-tolerance against cardiac injury afforded by exercise and diet.
-Fetal programming of cardiac mitochondrial fitness and relevance for adulthood pathologies.
-Regulation

of cardiac mitochondrial stress responses to drug-induced injury.
-Mitochondrial alterations during stem cell differentiation and carcinogenesis.
-Use of mitochondrial-directed natural and synthetic compounds as anti-cancer and anti-oxidant agents.

New breakthrough in cardiovascular research! Our team has uncovered key mechanisms to prevent heart disease. Portuguese ...
03/02/2025

New breakthrough in cardiovascular research! Our team has uncovered key mechanisms to prevent heart disease. Portuguese science at its best

As doenças cardiovasculares são a principal causa de morte em Portugal e no mundo e vitimam mais de 18 milhões de pessoas todos os anos. A descoberta agora feita é de uma equipa da Universidade de Coimbra.

✨ Artigo Disponível! ✨Estou muito entusiasmado em compartilhar o nosso estudo: "Maternal heart exhibits metabolic and re...
09/10/2024

✨ Artigo Disponível! ✨

Estou muito entusiasmado em compartilhar o nosso estudo: "Maternal heart exhibits metabolic and redox adaptations post-uncomplicated pregnancy". Este trabalho traz novas descobertas sobre como o coração materno se adapta metabolicamente e em termos de equilíbrio redox após uma gravidez sem complicações.

A melhor parte? podes acessar o artigo completo gratuitamente até 28 de novembro de 2024! Aproveite esta oportunidade para ler e descarregar o artigo completo, sem necessidade de registro ou taxas.

📖 Descarrega aqui: https://authors.elsevier.com/a/1jvLO3IQ%7EqMP7P

Curioso para saber mais? Deixe seus comentários abaixo! 👇

Pregnancy may be a challenging period for the maternal systems and has been regarded as a stress test, as imperceptible/mild dysfunctions eventually p…

🌟 Entendendo o Coração de uma Mãe 🌟É com entusiasmo que partilho o nosso recente manuscrito "O Coração Materno Exibe Ada...
07/10/2024

🌟 Entendendo o Coração de uma Mãe 🌟

É com entusiasmo que partilho o nosso recente manuscrito "O Coração Materno Exibe Adaptações Metabólicas e de Redox após uma Gravidez sem Complicações" na Biochimica et Biophysica Acta – Molecular Basis of Disease!

Este estudo contribui para a compreensão da saúde cardiovascular materna, destacando "as marcas moleculares" que a gravidez deixa no coração materno, as quais podem ser cruciais na avaliação de riscos cardiovasculares futuros em mães.

artigo integral: https://www.sciencedirect.com/science/article/pii/S0925443924005337

🌟 Understanding a Mother's Heart🌟

Excited to share our recent manuscript "Maternal Heart Exhibits Metabolic and Redox Adaptations Post-Uncomplicated Pregnancy" in Biochimica et Biophysica Acta – Molecular Basis of Disease!

This study advances our understanding of maternal cardiovascular health, highlighting how pregnancy leaves a long-lasting imprint on the heart, which may be critical in assessing future cardiovascular risks in mothers.

full: https://www.sciencedirect.com/science/article/pii/S0925443924005337



Universidade de Coimbra
CNC UC
Ciafel
FADEUP

🔬 Descoberta revolucionária sobre o envelhecimento cardíaco! 🫀Uma equipa de investigação internacional, com a participaç...
01/10/2024

🔬 Descoberta revolucionária sobre o envelhecimento cardíaco! 🫀

Uma equipa de investigação internacional, com a participação da UUniversidade de Coimbrae , desvendou um mecanismo crucial no envelhecimento natural do coração. Estes novos dados podem abrir portas para diagnósticos mais precoces e tratamentos preventivos de doenças cardiacas!

📰 Lê mais sobre esta descoberta e como pode transformar o futuro da saúde cardiovascular:
https://noticias.uc.pt/artigos/cientistas-desvendam-mecanismo-de-envelhecimento-do-coracao-que-pode-potenciar-o-aparecimento-de-doencas-cardiovasculares/

https://onlinelibrary.wiley.com/doi/10.1002/advs.202309211

🔬 Revolutionary discovery in heart aging! 🫀

An international research team, with the participation of the University of Coimbra, has uncovered a crucial mechanism in the natural aging of the heart. These new findings could pave the way for earlier diagnoses and preventive treatments for heart diseases!

📰 Read more about this discovery and how it could transform the future of cardiovascular health:
https://noticias.uc.pt/artigos/cientistas-desvendam-mecanismo-de-envelhecimento-do-coracao-que-pode-potenciar-o-aparecimento-de-doencas-cardiovasculares/

https://onlinelibrary.wiley.com/doi/10.1002/advs.202309211

This study examines baboon heart left ventricles across the adult lifespan (equivalent to human ages 30–88 years) to identify early aging-related cardiac changes. It reveals that aging in primates ca...

No passado dia 2 de Dezembro, os alunos de doutoramento Gabriela Oliveira e Luís Grilo foram distinguidos com o prémio d...
06/12/2023

No passado dia 2 de Dezembro, os alunos de doutoramento Gabriela Oliveira e Luís Grilo foram distinguidos com o prémio de melhor poster no congresso "Mitochondria in Aging, Cancer and Cell Death" que decorreu em Coimbra. Parabéns aos dois! 👏

----

On December 2nd, the PhD students Gabriela L. Oliveira and Luís F. Grilo were awarded the Best Poster Awards at the conference "Mitochondria in Aging, Cancer and Cell Death" which took place in Coimbra. Congratulations! 👏

🏆 Parabéns à colaboradora do Mitochondrial Toxicology and Experimental Therapeutics Susana P. Pereira, vencedora do Prêm...
27/09/2023

🏆 Parabéns à colaboradora do Mitochondrial Toxicology and Experimental Therapeutics Susana P. Pereira, vencedora do Prêmio BiotechSTARS BioBOOST! 🌟

Hoje é um dia de celebração e reconhecimento! Temos o prazer de anunciar que Susana P. Pereira, investigadora da Universidade do Porto e colaboradora do MitoXT, recebeu o prestigiado Prémio BiotechSTARS BioBOOST pelo projeto PREDICT: Predicting Cardiovascular Disease Risk at Birth.

👏🎉O projeto PREDICT é uma verdadeira revolução no campo da saúde, antecipando o risco de doenças cardiovasculares desde o nascimento. O empenho e dedicação da Susana e sua equipa na área da ciência é verdadeiramente inspirador, este prémio é mais uma prova do seu talento e perseverança.

🔬 Queremos agradecer a todos que apoiam e acreditam no nosso trabalho, pois este prémio também é de vocês. Continuaremos a avançar na ciência e na pesquisa para criar um mundo mais saudável e promissor para todos.

🌍💪

Congratulations to the Mitochondrial Toxicology and Experimental Therapeutics collaborator Susana P. Pereira, winner of the BiotechSTARS BioBOOST Award! 🌟

Today is a day of celebration and recognition! We are delighted to announce that Susana P. Pereira scientist at University of Porto and collaborator of MitoXT, has received the prestigious BiotechSTARS BioBOOST Award for her exceptional project, "PREDICT: Predicting Cardiovascular Disease Risk at Birth."

The PREDICT project is a true revolution in the field of health, foreseeing cardiovascular disease risks at birth. Susana and her team's dedication to the field of science is truly inspiring, and this award is a testament to their talent and perseverance.

We want to thank everyone who supports and believes in our work, as this award belongs to you as well. We will continue to advance in science and research to create a healthier and more promising world for all.

25/09/2023

📢 Attention all scientists interested in presenting their research on mitochondria at MAC 2023! 📢 Don't forget that the deadline for abstract submission is fast approaching. Submit your abstract by September 25 for a chance to present your work at the upcoming conference in Coimbra, Portugal. We welcome abstracts related to the role of mitochondria in aging, cancer, and cell death. The selection of Short Talks will prioritize junior scientists and aim for gender balance. Additionally, selected poster presenters will have the opportunity to give a Flash Talk, providing further opportunities for sharing research. Submit your abstract today and join us in Coimbra this November! IIIUC - Instituto de Investigação Interdisciplinar da Universidade de CoimbraCNC UCMitochondrial Toxicology and Experimental TherapeuticsUniversidade de Coimbra

15/09/2023

EXCITING ANNOUNCEMENT AHEAD!!! We are thrilled to share that abstracts from MAC2023 will be prominently showcased in a dedicated special edition of BBA - Molecular Basis of Disease. You now have an additional 10 days to submit your abstracts! Seize this exceptional opportunity – don't let it slip away!
(https://bit.ly/mac_2023)

CNC UCUniversidade de CoimbraMitochondrial Toxicology and Experimental TherapeuticsIIIUC - Instituto de Investigação Interdisciplinar da Universidade de Coimbra

11/09/2023

📢 Attention all scientists interested in presenting their research on mitochondria at MAC 2023! 📢 Don't forget that the deadline for abstract submission is fast approaching. Submit your abstract by September 15 for a chance to present your work at the upcoming conference in Coimbra, Portugal. We welcome abstracts related to the role of mitochondria in aging, cancer, and cell death. The selection of Short Talks will prioritize junior scientists and aim for gender balance. Additionally, selected poster presenters will have the opportunity to give a Flash Talk, providing further opportunities for sharing research. Submit your abstract today and join us in Coimbra this November!
CNC UC
Mitochondrial Toxicology and Experimental Therapeutics
Universidade de Coimbra
IIIUC - Instituto de Investigação Interdisciplinar da Universidade de Coimbra

20/07/2023

Join us at MAC 2023 to hear from Prof. Natalia Prevarskaya from the University of Lille, France, as she speaks about the role of calcium signaling in prostate cancer, with a focus on senescence and mitochondrial dysfunction.
Her research has important implications for the development of novel therapies for prostate cancer.
Don't miss out on this exciting opportunity to learn from one of the leading experts in the field.
Register for MAC 2023 now!



CNC UC Mitochondrial Toxicology and Experimental Therapeutics Universidade de Coimbra IIIUC - Instituto de Investigação Interdisciplinar da Universidade de Coimbra

Endereço

CNC/Center For Neuroscience And Cell Biology, University Of Coimbra
Cantanhede
3060-197CANTANHEDE,

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