Gharip Biotech

11/06/2026

اعلان مهم

بدء التقديم لبرنامج ماجستير المعلوماتية الحيوية من خلال الضغط على الرابط:

http://postgraduate-nubri.nu.edu.sd/

#بورتسودان #السودان

07/04/2026

12/03/2026

https://youtu.be/7blkYsbShzc
This video illustrates the hereditary patterns of X-linked recessive traits when a mother possesses a mutated gene. In the first scenario, a carrier mother and a healthy father have a 50% chance of producing sons who express the condition and a 50% chance of having daughters who serve as carriers. The Punnett square visually demonstrates how s*x chromosomes segregate to determine these specific biological outcomes for offspring. A second scenario describes a homozygous mother, whose genetic makeup ensures that all male children will inherit the disorder. Meanwhile, every daughter born to a homozygous mother will become a genetic carrier regardless of the father's health. These examples highlight how maternal genetics uniquely influence the health risks of children based on their biological s*x.

This Video illustrates the hereditary patterns of X-linked recessive traits when a mother possesses a mutated gene. In the first scenario, a carrier mother a...

25/01/2026

24/01/2026

https://youtu.be/wSXY3pFOoBc
This module explores the transformative impact of medical genomics on the field of oncology, shifting the focus from generalized treatments to personalized medicine. Traditional methods often rely on clinical trial averages, but genomic analysis reveals that cancers like breast cancer and lymphoma are actually collections of distinct molecular subtypes requiring specific therapies. By utilizing transcriptome clustering and circulating tumor DNA monitoring, doctors can now predict treatment responses and track how a tumor evolves and mutates during recurrence. The text highlights successful cases where targeted therapies, such as vitamin derivatives for specific leukemias, have dramatically improved survival rates. However, this rapid advancement introduces significant ethical and practical challenges regarding the standard of care and the ability of clinicians to stay current with evolving research. Ultimately, the source emphasizes that understanding a tumor's unique genetic signature is essential for effective, modern cancer management.

This module explores the transformative impact of medical genomics on the field of oncology, shifting the focus from generalized treatments to personalized m...

23/01/2026

https://youtu.be/6bdpjTLwtMI
Title: Somatic mosaicism for copy-neutral loss of heterozygosity and DNA copy number variations in the human genome

Journal: BMC Genomics (2015), Volume 16, Article number: 703
DOI: 10.1186/s12864-015-1916-3
Access: Open Access

Authors:
Olga Zilina¹,²* (Corresponding author)
Marina Koltsina¹
Raivo Raid¹
Ants Kurg¹
Neeme Tõnisson²,³†
Andres Salumets⁴,⁵,⁶†

This review examines genomic mosaicism, a condition where cells within a single individual possess distinct genetic profiles due to post-zygotic mutations. While historical research prioritized its role in cancers and overgrowth syndromes, contemporary studies highlight its presence in healthy brain development and the aging process. The authors detail various mutation types, ranging from single nucleotide variants to large structural alterations, and explain how these serve as permanent "barcodes" for tracing cellular lineages. Advances in next-generation sequencing and single-cell analysis have revolutionized the detection of these variants, moving beyond traditional visualization methods like FISH. The text further explores the utility of natural and engineered mosaicism as tools for mapping the environmental exposures and developmental histories of neurons. Ultimately, the source frames mosaicism as both a potential driver of neurological disease and a powerful recorder of a cell's biological past.

Title: Somatic mosaicism for copy-neutral loss of heterozygosity and DNA copy number variations in the human genomeJournal: BMC Genomics (2015), Volume 16, A...

22/01/2026

https://www.lshtm.ac.uk/study/courses/short-courses/intermediate-pharmacoepidemiology-pharmacovigilance?utm_source=linkedin&utm_medium=cpc&utm_campaign=short_course&utm_content=sph3&li_fat_id=cbda8444-4f7c-43b9-ba4a-bdae3b42d0e3