BIA Separations produces pre-packed HPLC chromatographic columns that enable high speed purifications of virus vaccines, viral vectors for gene therapy, bacteriophages, VLPs, pDNA, mAbs (IgG, IgM) and PEGylated proteins accompanied with efficient removal of RNA up to industrial scale. We are a worldwide provider of simple solutions for biopharmaceutical companies in the fields of HPLC based downst
ream purification processes and process analytical technology (PAT). Products:
Preparative HPLC columns exhibit unrivaled high operational flow rates, binding capacity, separation resolution and simple scale-up thus enabling highly economic purification processes for different biopharmaceuticals. Columns are:
1) Pre-packed,
2) Reusable,
3) Available in different sizes from 0.1 mL up to 8 L format,
4) Available for different chromatographic modes (ion exchanging chromatography, hydrophobic interaction chromatography, affinity chromatography)
5) Flexible towards customer applications (different pore sizes; sterile and non-sterile, cGMP compliant and non-cGMP compliant…). Analytical CIMac columns accompanied with analytical HPLC system and special software PATfinder enable our customers to preform analytical tasks for up- and downstream in only minutes. BIA Separations is proud of providing its customers with specific analytical columns for quantification of specific biopharmaceuticals such as plasmid DNA, adeno viruses and antibodies. For more details visit www.biaseparations.com
Applications:
CIM chromatographic columns provide you with fascinating results in the fields of downstream processing for production of biopharmaceuticals as well as in the fields of process analytical technologies for analytics and quality control applications. Production of biopharmaceuticals: CIM columns are most suitable for concentration and purification of virus vaccines, viral vectors for gene therapy, bacteriophages, VLPs, pDNA, mAbs (IgG, IgM) and PEGylated proteins accompanied with efficient removal of RNA, endotoxins and other impurities. Process Analytical Technology: CIMac columns and PATfinder are the solutions for analytical needs in research, process development, manufacturing of biopharmaceuticals and quality control of biopharmaceuticals! Due to flow independent resolution CIMac columns enable the fastest high resolution analytics of large biomolecules available on the market! In addition, PATfinder HPLC system and software are capable of real-time monitoring of your active compound and the impurities at any stage of your bioprocessing. Services:
BIA Separations offers different services for our customers including tech support (via mails or on-site!), process development (CRO) for complete DSP processes and PAT and training programs designed to cater to our customers needs. Chromatographic monoliths enable immobilization of different affinity ligands, such as proteins, peptides, nucleotides etc. If you lack knowledge and skills, BIA Separations can do the optimization of ligand binding and testing of the prepared affinity columns. One of the routine services we offer is the immobilization of polyclonal and monoclonal antibodies to provide the customer with immunoaffinity sorbents. We have well educated and experienced staff, high-tech facility with state-of-the-art techniques and equipment, cGMP production, BSL2 lab and certificates (ISO, FDA). As a reliable partner we can provide complete solutions for downstream processes.
