Dvojica

19/06/2026

19/06/2026

Background Synthetic Notch (synNotch) receptors are a powerful gene regulation platform that activate transcription in response to membrane-bound ligands and extracellular matrix components, with emerging applications in cancer, autoimmunity, and regenerative medicine. Whether synNotch can be adapte...

19/06/2026

Alzheimer’s disease is the most common form of dementia; however, its molecular mechanisms are not fully understood. We recently identified polymeric glycine–arginine-containing (polyGR+) aggregates as a novel type of proteinopathy in AD autopsy brains. Here, we performed a comprehensive analysi...

19/06/2026

Chronic primary low back pain (cpLBP) is a leading contributor to years lived with disability. Early-life stress is a major risk factor predisposing to cpLBP later in life upon minor injuries. We investigated s*x differences in the involvement of microglia in the pathophysiology of early-life stress...

19/06/2026

Activity in the parabrachial calcitonin gene‐related peptide to bed nucleus of the stria terminalis (PBN[CGRP] → BNST) circuit associates with anxiety‐like behavior. To test whether previous stress‐induced anxiety is associated with neuronal ...

19/06/2026

Monkeypox, a zoonotic disease caused by the monkeypox virus (MPXV), has significant global public health implications. Inflammasomes serve as crucial components of the innate immune system, detecting pathogens and triggering cell death in infected cells to eliminate harmful agents. However, the prec...

19/06/2026

Hepatitis B virus (HBV) is a hepatotropic DNA virus that infects over 250 million people worldwide and causes serious liver diseases. HBV infection can modulate host cellular processes, potentially inducing proteomic changes in hepatocytes. In this study, we investigated how acute HBV infection al...

19/06/2026

Chronic cadmium exposure, even in environmental doses, has been linked to multiple metabolic disturbances, including white adipose tissue (WAT) dysfunction. WAT dysfunction is defined as a loss of endocrine, immunologic, and metabolic homeostasis, characterized by a low-grade, progressive, and non-r...