08/11/2025
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Laboratory and Clinical Department of Molecular immunopharmacology
Kharkov
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In August 1886, the Kharkov Medical Society took the decision to establish a Pasteur vaccination institute and a bacteriological station that were open on 20 April 1887. The first directors were appointed U. U. Motte and N. A. Protopopov.
The institute's formation and growth was going on in conditions of struggling with epidemics of formidable infectious diseases. The founders of native microbiology, epidemiology, vaccine serum production were prominent scientists V. K. Vysokovich, S. I. Zlatogorov, V. I. Nedrigaylov; S. V. Korshun, S. M. Kotsevalov, active members of Soviet Medical Sciences Academy M. M. Tsekhnovitser, M. N. Solovyov, V. M. Zhdanov, associate member of Soviet Medical Sciences Academy V. S. Derkach, and many other prominent microbiologists, epidemiologists, general pathology experts were at various times administering or co-operating in the institute.
In spite of critical epidemiological condition in the country during the first years of Soviet power theoretical research was conducted in the institute to develop methods to fight cholera, dysentery, spotted and typhoid fever, to prevent and cure especially dangerous infectious diseases. To lower the levels TB morbidity a number of measures, both social and medical, had to be carried out. Research on TB was conducted in the institute since 1921; tuberculin production was organised, and for the first time in the country's history anti-tuberculosis vaccine production was set up to immunise children, regular anti-tuberculosis vaccination was initiated. Diphtheric and scarlet fever infections were researched here since the day of the institute's foundation, since 1925 special emphasis was placed on anaerobe infection research botulism, tetanus, anaerobe gangrene. Since after the war the production of 12 types of sera and 10 types of vaccines was started. From 1931 to 1941 the All-Ukrainian Mechnikov Institute of bacteriology, epidemiology, and serum-therapy - this was the name of the institute at that time - concentrates its efforts on anti-epidemic research in Donbass, developing active immunisation vaccines (enteric, scarlet fever); bacteriophage, bacterial antiagents chemistry studies, complex vaccine development. At this time the amount vaccine and serum preparations was greatly increased - in 1940 their list comprised 37 items. Since the very beginning of the Great Patriotic War the institute's activities were completely dedicated to the needs of the war. The production of tetanus sera, anti-gangrene preparations, vaccines against typhoid fever and cholera. The records of 1942 say: 110 000 wounded people were vaccinated against anaerobe gangrene, more than 1 120 000 soldiers were injected with serum against tetanus made in the institute. The institute's staff was repeatedly praised by high command for uninterrupted supply of vaccine and serum preparations.
Immediately after the end of the war a new and promising course of action was taken in the institute - the development of anti- microbe remedies and preventative medicines, the antibiotic sanasin and antitumor preparation neocid were developed. On the regained territory scientists organise and administer anti-epidemic campaign, fighting mass diseases typhoid fever and parasitogenic disease, dysentery, diphtheria.