03/24/2022
March is multiple sclerosis (MS) awareness month! MS is the most common disease in which myelin, the insulating sheath surrounding the neurons of the brain and spinal cord, degrades and is not repaired. Pinto, et al. describe a platform utilizing rat cerebellar slices and primary microglia to model demyelination and remyelination ex vivo. The clearance of myelin debris by microglia is a critical step in repair of the myelin sheath. They induced demyelination in their slices, and, using a unique fluorescent probe, they were able to track the fate of this debris as it was cleared, supporting it as a candidate for diagnostic imaging of MS. Check out how our Perfused Organ Panel featuring Blood Substitute can improve the viability of tissue slices: https://www.lenabio.com/perfused-organ-panel1.html
Read more:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620345/pdf/cells-10-03163.pdf