BWH Platelet and Megakaryocyte Group

BWH Platelet and Megakaryocyte Group We study platelets and megakaryocytes in health and disease! Labs include: Italiano, Battinelli, Machlus, and Giannini

Circulating blood platelets are specialized cells that function to prevent bleeding and minimize blood vessel injury. As such, platelets play a critical role in both normal and disease physiology. Large progenitor cells in the bone marrow called megakaryocytes (MKs) release platelets by extending long processes, proplatelets, into sinusoidal blood vessels. Some of the topics we study are:
- How an

d why megakaryocytes make platelets
- How different disease states such as inflammation and cancer alter megakaryocyte and platelet function
- What regulates platelet life-span

Our goal is to create novel therapeutics to treat thrombocytopenia and platelet disorders.

Welcoming some new lab members with a perfect fall afternoon
10/12/2020

Welcoming some new lab members with a perfect fall afternoon

Finally some help with NIH grant writing. Opie has some thoughts on hypotheses and rigor!
04/30/2020

Finally some help with NIH grant writing. Opie has some thoughts on hypotheses and rigor!

While most of the time I have to live vicariously (doing science) through our postdocs and graduate student, there is no...
03/06/2020

While most of the time I have to live vicariously (doing science) through our postdocs and graduate student, there is nothing like being at the bench- love it!

One of the best parts of the holidays is when lab alumni stop by. Today we were treated to a visit from Tom- former tech...
12/20/2019

One of the best parts of the holidays is when lab alumni stop by. Today we were treated to a visit from Tom- former technician who is now finishing up Medical school at Tufts. So proud of all he’s done since leaving us!!!

Special thanks to everyone for a great holiday lunch at Toro. I feel privileged to work with such a great team.
12/16/2019

Special thanks to everyone for a great holiday lunch at Toro. I feel privileged to work with such a great team.

Special thanks to Ed Conway for giving me the opportunity to speak at the 2019 Earl Davie Symposium.
11/22/2019

Special thanks to Ed Conway for giving me the opportunity to speak at the 2019 Earl Davie Symposium.

Great opportunity to present our science at the 2019 Biotek Imaging and Microscopy Meeting in Cambridge, MA
11/15/2019

Great opportunity to present our science at the 2019 Biotek Imaging and Microscopy Meeting in Cambridge, MA

Our experiments are finally working- divine intervention?
10/31/2019

Our experiments are finally working- divine intervention?

Special Thanks to everyone in the academic lab at Harvard Medical School for helping me celebrate the BIG 50 with an 80s...
10/08/2019

Special Thanks to everyone in the academic lab at Harvard Medical School for helping me celebrate the BIG 50 with an 80s themed party!

Great talk by Dr. Roy Silverstein, Chair of Medicine at the Medical College of Wisconsin and President of The American S...
09/27/2019

Great talk by Dr. Roy Silverstein, Chair of Medicine at the Medical College of Wisconsin and President of The American Society of Hematology. Roy delivered the 26th Annual BWH Hematology Moloney Lecture. Always a pleasure to talk platelet biology with Roy.

I was in Portland, Maine in search of oysters and ran into one of our old research technicians- Tom Soussou. What a gre...
08/19/2019

I was in Portland, Maine in search of oysters and ran into one of our old research technicians- Tom Soussou. What a great surprise. And I found some yummy oysters.

We are so excited to share with you our most recent article, out in the current issue of ATVB! Leila, Shauna, and Kellie...
07/17/2019

We are so excited to share with you our most recent article, out in the current issue of ATVB! Leila, Shauna, and Kellie have taken on the daunting task of reviewing the state-of-the-art on Megakaryopoiesis in this exciting and ever changing field.
https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.312129

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4 Blackfan Circle, HIM 7
Boston, MA
02115

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