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Epion Therapeutics (Epion) is developing innovative treatments for corneal diseases with the goal of saving and improving vision for millions of patients around the world.

10/11/2025

Today is World Keratoconus Day, an opportunity to raise awareness for a common condition with huge impacts to vision, quality of life, and emotional well-being.

Historically, prevalence has been reported as 1 in 2000 patients. With advances in diagnostics and increased screening, we now know keratoconus affects far more people.

Awareness, early detection, and innovation can make a real difference for those living with keratoconus. At Epion, we’re proud to be part of the growing effort to better understand and treat keratoconus.

26/11/2024

🌟 Epion Featured in Recent National Keratoconus Foundation Newsletter! 🌟

We’re proud to share that Epion Therapeutics and our innovative Phase 3 clinical trials were highlighted in the latest NKCF newsletter!

📖 Read the full newsletter now: https://www.epiontx.com/featured-articles/phase-3-trials-in-focus-advances-in-cross-linking-for-keratoconus

NKCF regularly shares exciting new research opportunities with their patient and physician audiences. Make sure to subscribe to future communications from NKCF at their website!

In their latest newsletter, the National Keratoconus Foundation (NKCF), highlights Epion Therapeutics’ Phase 3 trials of the EpiSmart Epithelium-On Cross-Linking System.

03/09/2024

🆕 Exciting News for Keratoconus Patients!

We're thrilled to share our latest video featuring Dr. Ovette Villavicencio, who introduces the EpiSmart Epi-On Corneal Cross-linking procedure. 👁️🔆 This innovative treatment, currently in Phase 3 trials, aims to improve patient outcomes by reducing discomfort, speeding recovery, and offering treatment of both eyes at the same time.

Join Dr. Ovette Villavicencio, a leading cornea specialist, as he introduces EpiSmart Epi-On Corneal Cross-linking—an investigational treatment for keratocon...

27/08/2024

🔗 𝗪𝗵𝗮𝘁 𝗶𝘀 𝗖𝗿𝗼𝘀𝘀-𝗟𝗶𝗻𝗸𝗶𝗻𝗴?
Corneal cross-linking uses vitamin B2 (also known as riboflavin) and ultraviolet light to form new bonds between collagen molecules in the eye, helping to stiffen the cornea. Although epithelium-off cross-linking is effective, the current approach involves removing the cornea’s epithelium to allow riboflavin to pe*****te. Removing this outer layer can be painful and is associated with a slow recovery and occasional corneal scarring.

💡𝗪𝗵𝗮𝘁 𝗶𝘀 𝗘𝗽𝗶𝗦𝗺𝗮𝗿𝘁?
EpiSmart is an investigational epithelium-on cross-linking system for keratoconus in Phase 3 trials. The new approach relies on a modified form of riboflavin which pe*****tes deep into the cornea 𝙬𝙞𝙩𝙝𝙤𝙪𝙩 𝙘𝙝𝙚𝙢𝙞𝙘𝙖𝙡 𝙤𝙧 𝙢𝙚𝙘𝙝𝙖𝙣𝙞𝙘𝙖𝙡 𝙙𝙞𝙨𝙧𝙪𝙥𝙩𝙞𝙤𝙣 𝙤𝙛 𝙩𝙝𝙚 𝙚𝙥𝙞𝙩𝙝𝙚𝙡𝙞𝙪𝙢. The procedure lasts approximately 50 minutes, including 30 minutes of riboflavin application and 20 minutes of ultraviolet treatment.

🤔 𝗪𝗵𝘆 𝗘𝗽𝗶𝗦𝗺𝗮𝗿𝘁?
Since EpiSmart does not require the removal of the corneal outer layer (epithelium), most patients were able to return to normal activities quickly and reported improvements in their visual performance. EpiSmart can be used to treat both eyes in a single session.

▶️ 𝗖𝗵𝗲𝗰𝗸 𝗼𝘂𝘁 𝘁𝗵𝗲 𝘃𝗶𝗱𝗲𝗼 𝘁𝗼 𝗹𝗲𝗮𝗿𝗻 𝗺𝗼𝗿𝗲 𝗮𝗯𝗼𝘂𝘁 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁𝘀 𝗶𝗻 𝗸𝗲𝗿𝗮𝘁𝗼𝗰𝗼𝗻𝘂𝘀 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁!

Keratoconus is an eye disease affecting millions of individuals worldwide. The condition causes the transparent layer on the front of the eye, named the corn...

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1500 District Avenue

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https://www.epiontx.com/

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