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Monday 8:30am - 6pm Wednesday 8:30am - 6pm

Olaris, Inc, 175 Crossing Boulevard, Suite 410, Framingham, MA (2026)

06/11/2026

𝗜𝗻𝘁𝗿𝗼𝗱𝘂𝗰𝗶𝗻𝗴 𝗼𝘂𝗿 𝗻𝗲𝘄 𝗗𝗶𝗿𝗲𝗰𝘁𝗼𝗿 𝗼𝗳 𝗗𝗮𝘁𝗮 𝗘𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴, 𝗘𝗱𝘄𝗮𝗿𝗱 (𝗧𝗲𝗱) 𝗔𝗹𝗹𝗲𝗻!

We are thrilled to welcome Ted to the Olaris team as he helps us deliver actionable insights through integration of metabolomics, machine learning, and biology. Ted’s skills in software engineering and bioinformatics, combined with his biotherapeutics industry experience, will be instrumental as we continue to build and power diagnostics that reveal what is happening in disease.

06/09/2026

Our #𝐌𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐭𝐞𝐨𝐟𝐭𝐡𝐞𝐌𝐨𝐧𝐭𝐡 𝗖𝗿𝗲𝗮𝘁𝗶𝗻𝗶𝗻𝗲 is a metabolite of creatine and phosphocreatine. The word creatinine is derived from creatine named after the Greek word kreas (“meat”) by chemist Michel Eugène Chevreul who first isolated creatine from beef.

Creatine and phosphocreatine maintain ATP concentrations in muscle and other tissues with high-energy demands. Muscles do not store large amounts of ATP directly, but phosphocreatine can instantly donate its phosphate to recharge spent ATP.

Creatinine, the spontaneous non-enzymatic degradation product of creatine/phosphocreatine, diffuses out of cells into circulation and is eliminated in urine. Clinical testing of creatinine levels in blood and urine is used to measure how well kidneys filter waste from the body.

References: Delanghe et al., Journal of Thoracic Disease, 2016. DOI: 10.21037/jtd.2016.05.36; Popp et al., Diagnostics, 2023. DOI: 10.3390/diagnostics13101737; Wyss et al., Physiological Reviews, 2000. DOI: 10.1152/physrev.2000.80.3.1107

06/02/2026

𝗨𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱𝗶𝗻𝗴 𝗠𝗲𝗱𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗡𝗼𝗻-𝗔𝗱𝗵𝗲𝗿𝗲𝗻𝗰𝗲 𝗶𝗻 𝗢𝗿𝗴𝗮𝗻 𝗧𝗿𝗮𝗻𝘀𝗽𝗹𝗮𝗻𝘁

Medication adherence in organ transplant refers to the recipient following agreed upon recommendations and instructions from healthcare professionals for taking immunosuppressive medications at the prescribed dosage and times with consistency and persistence.

Medication non-adherence (MNA) is estimated to occur in 22-68% of transplant recipients and is responsible for approximately 50% of late rejections and 15% of graft loss.

The ability to adhere to a consistent immunosuppressant regimen is impacted by a variety of factors including difficulty obtaining medications, insurance issues, disruptions in daily routine, poor social support and drug side effects.

References: Bendersky, V. A. et al. (2023). Clinical Transplantation, 37(6), e14962. https://doi.org/10.1111/ctr.14962; Nevins, T. E., et al. (2017). Journal of the American Society of Nephrology, 28(8), 2290–2301. https://doi.org/10.1681/ASN.2017020216; Tang, J., et al. (2021). American Journal of Transplantation, 21(10), 3369–3387. https://doi.org/10.1111/ajt.16613

05/29/2026

Did you know? 70-80% of the body’s immune system cells reside in the gut. What we eat shapes our gut microbiota and the metabolites released there which regulate local and systemic immunity.
References: Wiertsema, S. P., et al. (2021). Nutrients, 13(3), Article 886. https://doi.org/10.3390/nu13030886; Yoo, B. B., & Mazmanian, S. K. (2017). Immunity, 46(6), 910–926. https://doi.org/10.1016/j.immuni.2017.05.011

05/28/2026

Should older kidney transplant recipients receive less immunosuppression?

Lower risk of rejection (under-immunosuppression)
• Aging immune systems (immunosenescence) are less reactive to the graft.
• Death with a functioning graft is more common due to comorbidities and infection.

Higher risk of over-immunosuppression
• Immunosenescence increases susceptibility to infection.
• Chronic kidney disease accelerates immunosenescence.
• Immunosuppression of an aging immune system may exacerbate risks of malignancy, cardiovascular disease and diabetes through chronic low-grade inflammation and reduced tumor surveillance.
• Older recipients often receive older donor kidneys that are more sensitive to drug toxicity.
• Age-related metabolic changes increase adverse effects.

Important considerations
• Older donor kidneys may have higher rejection risk.
• Rejection in older patients is more likely to be fatal or lead to graft loss.
• The OPTIMIZE study found that reduced immunosuppression was safe in older kidney transplant recipients but did not improve outcomes.
• Pharmacological studies have often excluded older patients.
• Better biomarkers are needed to guide personalized immunosuppression reduction.

References: Alshaer, I. et al. (2025) Journal of Transplantation, 2025(1). https://doi.org/10.1155/joot/5547629; Jallah, B.P., Kuypers, D.R.J. (2024) Drugs Aging, 41, 219-238. https://doi.org/10.1007/s40266-024-01100-5; University Medical Center Groningen (2025) https://umcgresearch.org/w/lower-immunosuppression-in-elderly-kidney-transplant-patients-is-safe-but-not-more-effective

05/26/2026

Voices of Transplant: Dr. Anil Chandraker, Chief of Nephrology, UMass Memorial Health, on the problem of over-immunosuppression after kidney transplant.

05/21/2026

Our melanin has three main types in humans: eumelanin, pheomelanin and neuromelanin. In skin, eumelanin and pheomelanin are synthesized from the amino acid tyrosine via tyrosinase and they protect us from UV radiation.

Neuromelanin, a complex polymeric molecule containing eumelanin and pheomelanin, concentrates in the substantia nigra pars compacta brain region, central to movement and reward, within catecholaminergic neurons. Neuromelanin is thought to mainly form from oxidative polymerization of dopamine with incorporation of cysteine. By soaking up toxic substances like heavy metals, neuromelanin helps protect neurons.

Neuromelanin accumulates as we age in the brain area prone to degeneration in Parkinson’s disease and other neurodegenerative disorders. Neuromelanin-sensitive imaging signals are being explored as a biomarker of brain health.

References: Brooks, J., et al. (2020). Angewandte Chemie (International ed. in English), 59(29), 11984–11991. https://doi.org/10.1002/anie.202000239 (Image Source: http://creativecommons.org/licenses/by/4.0/); Hatch, K. et al. (2026). Biomolecules, 16(1), 61. https://doi.org/10.3390/biom16010061 (Image Source: http://creativecommons.org/licenses/by/4.0/)

05/19/2026

Born on this day in 1859 was scientist 𝐉𝐨𝐡𝐧 𝐉𝐚𝐜𝐨𝐛 𝐀𝐛𝐞𝐥, who conceptualized dialysis, filtering waste from blood, a century before this life-sustaining treatment was used in patients with kidney failure in the 1950s.

The first description of dialysis, “On the Removal of Diffusible Substances From the Circulating Blood by Means of Dialysis”, in 1913 by Dr. John Abel and colleagues from Johns Hopkins University, was published in the Transactions of the Association of American Physicians.

Improved dialysis apparatus became practical for medical use once the materials cellophane (semi-permeable membrane), heparin (anticoagulant), and Teflon (non-stick cannula) replaced Abel’s collodion membrane, hirudin (from leech saliva), and glass.

References: Eknoyan, G. (2009). Seminars in Dialysis, 22(3), 287–296. https://doi.org/10.1111/j.1525-139x.2009.00527.x; Sharma, N., et al. (2024). Cureus. https://doi.org/10.7759/cureus.69098

05/15/2026

FRIDAY FUN FACT

Why does viral reactivation occur in astronauts?
A) Exposure to alien microbes 👽
B) Microgravity directly creates viruses
C) Immune dysregulation + stress hormones
D) Lack of vaccines

💡Transplant connection: Spaceflight alters T-cell function, cytokines, and stress responses. Immunosuppressant medications, while necessary for transplant recipients, can also lead to viral reactivation. Herpesviruses (e.g., EBV, CMV, VZV) establish lifelong latency and reactivate when immune control weakens in both spaceflight and immunosuppression. While reactivation is generally asymptomatic in astronauts, it is often symptomatic in transplant patients due to the higher, more sustained level of immunosuppression.

References: Moller, D.L., et al. Front Immunol 14, 1183703 (2023). doi: 10.3389/fimmu.2023.1183703; Winer, D.A., et al. Nat Rev Immunol 26, 189–212 (2026). https://doi.org/10.1038/s41577-025-01226-6

05/14/2026

𝐖𝐡𝐚𝐭 𝐭𝐨𝐨𝐥𝐬 𝐚𝐬𝐬𝐞𝐬𝐬 𝐨𝐯𝐞𝐫-𝐢𝐦𝐦𝐮𝐧𝐨𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐢𝐨𝐧?

𝙏𝙝𝙚𝙧𝙖𝙥𝙚𝙪𝙩𝙞𝙘 𝙙𝙧𝙪𝙜 𝙢𝙤𝙣𝙞𝙩𝙤𝙧𝙞𝙣𝙜 𝙗𝙡𝙤𝙤𝙙 𝙩𝙚𝙨𝙩𝙨
• Pharmacokinetic (PK) monitoring measures levels of immunosuppressant drugs within the body to ensure the appropriate dose.
• The state of immunosuppression varies between individuals and is not reliably captured by drug levels alone.

𝙑𝙞𝙧𝙖𝙡 𝙨𝙘𝙧𝙚𝙚𝙣𝙞𝙣𝙜
• Viral infection, such as BK polyomavirus, detected by nucleic acid testing, is a sign of over-immunosuppression.

𝙆𝙞𝙙𝙣𝙚𝙮 𝙜𝙧𝙖𝙛𝙩 𝙞𝙣𝙟𝙪𝙧𝙮 𝙨𝙪𝙧𝙫𝙚𝙞𝙡𝙡𝙖𝙣𝙘𝙚
• Immunosuppression adjustment is largely reactionary, with doses being increased with rejection and lowered with infection.
• Many tools are non-specific or specific to rejection (under-immunosuppression).
• Surveillance biopsies can detect the type of kidney injury early in clinically stable patients, but less than half of high-volume US transplant centers perform them because they are invasive and costly.
• myOLARIS-KTdx is a commercially available urine-based test under continued development and validation with potential to reduce unnecessary biopsies and guide personalized immunosuppression.

References: Ahlenstiel-Grunow T. and Pape L. (2021) Mol. Cell. Pediatr. 8: 8. https://doi.org/10.1186/s40348-021-00118-8; D**g C. et al. (2025) iScience. 28(9): 113331. 10.1016/j.isci.2025.113331; Han HS and Lubetzky ML (2023) Front. Nephrol. 3:1293907. doi: 10.3389/fneph.2023.1293907

Olaris, Inc

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