Biomedican, Inc.

09/13/2021

What are used to treat ?
✓ Many early evidences, anecdotal reports, and small clinical trials suggested the efficacy of phytocannabinoids in epilepsy.

∆ CBD: CBD is the most commonly analyzed anticonvulsant phytocannabinoid with sufficient data in many acute animal models but limited data in chronic models. Literature has reported nearly more than 65 molecular targets of . The exact mechanism of action of CBD as the anti-epileptic drug is still unknown, but literature documented the effect of CBD on the equilibrative nucleoside transporter(ENT), the orphan G-protein-coupled receptor GPR55; the transient receptor potential of vanilloid type-1 channel; the 5-HT1a receptor; and the α3 and α1 glycine receptors. Numerous studies also document the neuroprotective and anti-inflammatory effects of cannabinoids.

∆ CBDV: Another phytocannabinoid, cannabidivarin ( ), a direct analog of CBD derived from cannabigerovarin (CBGV), has shown a favorable pharmacokinetic profile and anticonvulsant effects. At micro-and nanomolar concentrations, it inhibits the reuptake of AEA and 2-AG.

: It is one of the important phytocannabinoids that is non-psychoactive. CBG potentially works as an antagonist of serotonin receptors. This data, along with other data, leads to the postulations that 5-HT2A receptor signaling is implicated in controlling neuronal excitability via GABAergic, glutamatergic, and monoaminergic neurotransmission. This acts as evidence of the possible anticonvulsant effects of CBG by direct modulation of activity at 5-HT2A receptors.
https://biomedican.com/cannabinoids-and-epilepsy-treatment/
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09/12/2021

The principle of the effect of cannabinoids on the human body
Humans have an endocannabinoid system (ECS) consisting of cannabinoid receptors, endocannabinoids, and enzymes. ECS is involved in several physiological processes and pathological conditions where it has a protective role. Cannabinoids interact with the cannabinoid receptors, i.e., CB1 and CB2, regulating these physiological and several pathological conditions such as epilepsy.
https://biomedican.com/cannabinoids-and-epilepsy-treatment/

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09/11/2021

~ as a treatment option for epilepsy~
✓ Ancient Greek and Arabic medical texts were the first literature that mentioned the use of natural cannabinoids in the treatment of seizures. Cannabis-based products were first utilized as an anti-seizure medication in 1843. Medical literature of the 1850s and 60s also reported the effectiveness of cannabis in treating several medical conditions, including epilepsy. In contrast, a few small case studies of the 1980s and 90s reported contradictory results. The limitations of these studies were the variable concentration of in the extracts. However, numerous other in vitro and in vivo studies documented the anti-epileptic effect.

✓ The U.S. Food & Drug Administration (FDA) approved EPIDIOLEX® (cannabidiol, CBD) oral solution on June 25, 2018, to treat seizures associated with- Lennox-Gastaut syndrome and Dravet syndrome. This CBD product was a new medication option for pediatric epilepsy. It was approved for use in people two years of age or older. Epidiolex represents the first-ever FDA-approved medication that can treat seizures associated with Dravet syndrome.
https://biomedican.com/cannabinoids-and-epilepsy-treatment/
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Since the FDA has approved cannabinoids, i.e., CBD, to treat Dravet syndrome and Lennox-Gastaut syndrome, the researchers are now evaluating other rare cannabinoids to treat infantile spasms, Fragile X syndrome, and Rett syndrome. Biosynthetic cannabinoids produced by Biomedican are the most reliabl...

09/10/2021

~Medical use of ~
✓ Apart from recreational use, human has a long history of using plant as a herbal remedy for various ailments. The advancement in science and medicine has found the chemical compounds (cannabinoids) of the ma*****na plant associated with medicinal effects. Cannabinoids are a group of chemical compounds with therapeutic potential obtained from the Cannabis Sativa plant.

✓Though federal governments have not yet legalized cannabinoids, most states have allowed the recreational and medicinal use of therapeutically potent chemical compounds. The FDA has approved the use of to treat seizures. Researchers are now studying cannabinoids as a potential pharmacological/therapeutic option to treat neuropsychiatric disorders, neurogenerative diseases, gastric disorders, movement disorders, and anti-cancerous therapy. Due to the effect of cannabinoids on endocannabinoid receptors, there are possibilities of various other medicinal uses of cannabinoids that are yet to discover.
https://biomedican.com/medical-use-of-cannabinoids/
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While CBD products pique consumer interest, scientists came to light another very high-end cannabinoid, i.e., CBG.

09/08/2021

The Bio Revolution marks the beginning of a new era: Innovations enabled by the convergence of biology and technology have the potential to significantly improve our lives, our nutrition, and our health.

Bio-Organic is the future of health and wellness.
Read more at: https://lnkd.in/dfPaRBSa

The world is rapidly changing, demanding Higher Quality, Less expensive food, drugs and other value high compounds be produced sustainably. The challenge is being met a in a significant way through cross pollination of Biosynthesis, Engineering, DNA and Computational computing.

09/08/2021

✓ There is plenty of money to be made: the size of the market alone in Mexico is expected to reach $249.6m by 2025, according to an analysis by United States-based consultancy Grand View Research.

✓ Major global cannabis firms such as Canopy Growth, BIOMEDICAN, Inc. and Aurora Cannabis have been keeping a close eye on the legislative developments in Mexico with a view to profit from a countrywide market once the legalisation bill passes.
Read more at: https://www-aljazeera-com.cdn.ampproject.org/c/s/www.aljazeera.com/amp/economy/2021/9/3/how-will-legal-cannabis-firms-navigate-mexicos-business-risks
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Major firms are eager to profit from a legal Mexican cannabis market, but will they be able to navigate the risks?

09/06/2021

~Benefits of biosynthesized ~
✓Conventional methods to yield cannabinoids are time-consuming and labor-consuming. The end product is not enough to fulfill the current market demand for cannabinoids. While, the Biosynthesis of cannabinoids allows the products to be faster, cost-effective, and more than conventional methods. Biosynthetic cannabinoids are produced through naturally occurring processes within a living organism. These processes of the living organism make the cannabinoids identical to the ones extracted from plants. Also, biosynthetic cannabinoids usually have higher quality, are , , and free or almost free of undesirable byproducts.
Read more at: https://biomedican.com/cannabinoids-and-cancer-treatment/
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09/05/2021

∆ Benefits of in the treatment of cancer ∆
✓ Though research found promising cannabinoids in cancer treatment, these aren’t conclusive and require more advanced study. However, cannabinoids have proven efficacy as a complementary therapy. For example, the US Food and Drug Administration (FDA) has approved delta-9-tetrahydrocannabinol (THC) in the treatment of nausea and vomiting induced by chemotherapy. A combination of and can also produce an analgesic effect in cancer patients. The rare cannabinoids CBN can help improve sleep as well as reduces pain sensations.

It is crucial to mention the preventive effect of rare cannabinoids such as , , , and . These cannabinoids produce reactive oxygen species andact as antioxidants, reduce inflammation, thus preventing colon cancer, and induce apoptosis. A 2015 study concluded that patients who consume cannabinoids have a 45% reduced risk of developing bladder cancer. In the light of the above research studies, it is safe to say that cannabinoids can effectively prevent tumorgenesis and exert a cytotoxic effect on tumor cells.
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09/04/2021

√ that can treat cancer

Several studies reported that and act as cannabinoids receptor agonists and exert an anti-tumor effect in experimental models. THC also induces cancer cell death by up-regulating nuclear protein 1 (Nupr1) and pseudo-kinase tribbles homolog 3 (TRIB3). (CBD) enhances reactive oxygen species production, activates TRPV2 receptors, and promotes cell death. A 2020 review study found that “∆9-THC and CBD increased the cytostatic effects of chemotherapeutic drugs”.

Rare cannabinoids such as , , , and also produce an anti-tumor effect by reducing angiogenesis, activating apoptotic pathways, and killing cancer cells.
Read more at: https://biomedican.com/cannabinoids-and-cancer-treatment/
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Research on cannabinoids as a potential treatment for cancer started after discovering various growth-limiting, apoptosis-inducing, and antioxidant properties of cannabinoids.

09/04/2021

beverages
✓ Cannabinoids are lipophilic; therefore, it is easy to incorporate them in butter and oils. Cannabinoids are not water soluble therefore food industries have developed techniques to infuse cannabinoids in various beverages. The aroma and taste in these beverages are maintained by using terpenes. Cannabis infuses beer, coffee, and cocktail are the most well-known beverages. Food industries are now incorporating cannabinoids in various energy drinks.

✓ Other than the edibles mentioned earlier, cannabinoids are now a part of honey, coconut oil, flour, truffles, cookies, bread, and butter.
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09/03/2021

gummies
Gummies are great for snacking as they are small and easy to carry while traveling, and not as sweet as chocolates. Cannabis gummies come in various shapes such as fish, worm, lime, rings, bear, and flavor combinations such as grape, lime, peach, and strawberry. Gummies may have psychoactive cannabinoids such as THC and non-psychoactive cannabinoids such as or . These gummies are often available in dispensaries in different states.
Cannabis capsules
Cannabis capsules are an excellent option for people who wants to consume for their therapeutic effect. Cannabis capsules are not sweet like chocolate and gummies. These are taken as a medicine and may contain therapeutically active cannabinoids without psychoactive effect. (cannabinol) capsules are most often utilized for their health benefits such as insomnia treatment.
Read more at: https://biomedican.com/cannabinoids-in-the-food-industry/
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09/02/2021

tincture
Tinctures are an alcoholic extract of a cannabis crude drug. These tinctures contain 60-70% alcohol. These concentrated tinctures are widely used sublingually. A few drops of tinctures are dropped below the tongue and absorbed. Sublingual route avoid hepatic metabolism and produce rapid effect.
chocolates
Since snacking on cannabis edibles is now legal, edibles are one of the most desirable ways. Consuming cannabis chocolates is a common cannabis consumption method for people who wants to consume cannabis in a refined form. These chocolates may contain THC that may get you high.
Scientists found anandamides while studying cannabinoid receptors that influence appetite, health, and pleasure—Anandamide level in the body increases by cannabis chocolate consumption, leading to analgesic and anti-inflammatory effects. The sugar in chocolate enhances the impact of cannabinoids on cannabinoids receptors. Cannabis chocolates show an effect in 20-60 minutes.
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