Castle Biosciences, Inc.

Castle Biosciences, Inc. Leading diagnostics company improving health through innovative tests that guide patient care. total addressable market.

At Castle, we aim to transform disease management by keeping people first — the patients who benefit from the information that our advanced diagnostic tests provide, the clinicians who use our tests to guide disease management decisions, our talented and valued employees, and our investors. For the diseases that our portfolio of tests cover, we believe the traditional approach to developing a trea

tment plan for cancers and other diseases using clinical and pathology factors alone is inadequate and can be improved by incorporating the personalized information our tests provide. Our innovative portfolio of commercial and pipeline tests targets unmet clinical need along the patient care continuum. We currently market five proprietary tests designed to answer clinical questions and address treatment plan challenges facing physicians in dermatologic cancers, uveal melanoma and Barrett’s esophagus. https://castletestinfo.com

Our test for invasive cutaneous melanoma, DecisionDx®-Melanoma, is a proprietary gene expression profile, or GEP, test that uses an individual patient’s tumor biology to predict the risk of metastasis or recurrence, as well as the risk of sentinel lymph node positivity, independent of traditional staging factors. https://castletestinfo.com/decisiondx-melanoma

DecisionDx®-SCC is our GEP test that predicts the risk of metastasis in patients with cutaneous squamous cell carcinoma, who have one or more risk factors. https://castletestinfo.com/products/decision-dx-scc

DecisionDx®-UM, the standard of care in uveal melanoma staging, is our GEP test that predicts the risk of metastasis for patients with uveal melanoma, a rare eye cancer. https://castletestinfo.com/products/decisiondx-um

Our comprehensive diagnostic offering — myPath® Melanoma and DecisionDx® DiffDx™-Melanoma — provides a highly accurate, objective result to aid dermatopathologists and dermatologists in characterizing suspicious pigmented lesions. https://castletestinfo.com/mypath-melanoma-diffdx-melanoma

TissueCypher® Barrett’s Esophagus is the world’s first precision medicine test designed to predict future development of esophageal cancer in patients with Barrett’s esophagus. https://tissuecypher.com

Together, we believe these commercial products support an estimated total addressable market of approximately $3 billion in the United States. Additionally, in 2021, we announced the launch of our innovative pipeline initiative to develop a genomic test aimed at predicting response to systemic therapy in patients with moderate-to-severe psoriasis, atopic dermatitis and related inflammatory skin conditions. If successful, this pipeline test has the potential to add approximately $1.9 billion to our current estimated U.S. Castle Biosciences (Nasdaq: CSTL) is based in Friendswood, Texas and has laboratory operations in Phoenix, Arizona, and Pittsburgh, Pennsylvania. For more information, please visit www.CastleBiosciences.com.

Thank you to all those who serve. Today and every day, we honor you and remember those who've made the ultimate sacrific...
05/25/2026

Thank you to all those who serve. Today and every day, we honor you and remember those who've made the ultimate sacrifice.

NEXT MONTH: Castle's executive management will present a company overview at the 2026 Jefferies Global Healthcare Confer...
05/13/2026

NEXT MONTH: Castle's executive management will present a company overview at the 2026 Jefferies Global Healthcare Conference on Wednesday, June 3, at 1:20pm ET.

Details/registration: https://hubs.la/Q04gszsM0

05/12/2026

This calls for a celebration!🎉 Castle's AdvanceAD-Tx test has won the Genomics Innovation Award in the 10th annual MedTech Breakthrough Awards program, which recognizes companies driving meaningful progress and improving patient care across the global health and medical technology industry. This marks the fifth MedTech Breakthrough Award that Castle has earned for our innovative testing solutions.

AdvanceAD-Tx is Castle's clinically validated gene expression profile (GEP) test designed to guide systemic treatment decision making in patients 12 and older with moderate-to-severe atopic dermatitis (AD). Further details: https://hubs.la/Q04gcQLR0

Gene Expression Profiling (GEP) is a laboratory testing method that measures which genes are being expressed in a cell a...
05/12/2026

Gene Expression Profiling (GEP) is a laboratory testing method that measures which genes are being expressed in a cell at any given moment.

Understanding the expression levels of certain genes for a specific type of cancer helps to create a molecular portrait of the cancer. This information can provide a deeper understanding of the biology of a tumor, which can vary from patient to patient, and can be utilized in several ways: to diagnose a disease or condition, to understand response to therapy, or to provide prognostic information, all of which can guide clinical management decisions.


We would walk forever for a cure! 💙  was proud to support AIM at Melanoma's 20th annual Steps Against Melanoma walk in G...
05/07/2026

We would walk forever for a cure! 💙 was proud to support AIM at Melanoma's 20th annual Steps Against Melanoma walk in Galveston, Texas, helping to raise awareness, fund research, and support patients and caregivers every step of the way.

Representing : Camilla Zuckero, Olga Cain, and Carmen Gomez

JUST RELEASED: Castle Biosciences announces financial results for the 1st quarter ended 3/31/26Q1 2026 Highlights: Reven...
05/06/2026

JUST RELEASED: Castle Biosciences announces financial results for the 1st quarter ended 3/31/26

Q1 2026 Highlights: Revenue of $83.7 million; Q1 2026 total test reports for our core revenue drivers (DecisionDx®-Melanoma, TissueCypher®) increased 36% over Q1 2025; raising full-year 2026 revenue guidance to $345-355 million from $340-350 million, as of 3/31/26

View further results and access the webcast archive here: https://hubs.la/Q04fJRBS0

JOIN US TODAY: Castle will release Q1 2026 financial results via webcast at 4:30 pm ET. Registration/log-in details: htt...
05/06/2026

JOIN US TODAY: Castle will release Q1 2026 financial results via webcast at 4:30 pm ET. Registration/log-in details: https://hubs.la/Q04c9vpT0

In honor of  , Castle continues longstanding collaborations with AIM at Melanoma, the Melanoma Research Foundation, The ...
05/05/2026

In honor of , Castle continues longstanding collaborations with AIM at Melanoma, the Melanoma Research Foundation, The Skin Cancer Foundation, IMPACT Melanoma, and The Sun Bus to advance awareness and education through several community initiatives, including advocacy walks, skin cancer screenings, and patient education programs nationwide.

Press release: https://hubs.la/Q04fvqSM0

NEW DATA generated by researchers at Mayo Clinic will be presented at Digestive Disease Week®  , taking place May 2–5 in...
05/04/2026

NEW DATA generated by researchers at Mayo Clinic will be presented at Digestive Disease Week® , taking place May 2–5 in Chicago. The findings, featured in two poster presentations, demonstrate how molecular risk stratification with the TissueCypher test can refine risk assessment and directly inform real-world management decisions for patients with Barrett's esophagus.

"The findings presented at DDW 2026 suggest that relying on traditional clinical risk assessment alone may not fully capture a patient's true risk of progression," said Cadman L. Leggett, M.D., gastroenterologist at Mayo Clinic and senior author on both studies. "Molecular risk stratification with TissueCypher can provide more clinically actionable insights by more accurately identifying which patients are truly at higher or lower risk. And we see that translating into real-world changes in how physicians manage patients."

Details: https://hubs.la/Q04flflr0

05/04/2026

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Friendswood, TX

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