10/01/2026
What happens when exosomes meet microneedling? A randomized, split-face clinical study set out to answer exactly that.
28 adults with facial wrinkles had microneedling on both sides of the face. One side received adipose-derived stem cell exosomes; the other received saline. After 12 weeks, the exosome side showed greater improvement in:
— wrinkles
— elasticity
— hydration
— pigmentation
No adverse reactions were reported.
Study: Park GH, Kwon HH, Seok J, et al. Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: a 12-week prospective, randomized, split-face study. J Cosmet Dermatol. 2023;22(12):3418–3426. doi:10.1111/jocd.15872
Findings reflect a single study. Individual results vary. This post is not medical advice.