08/12/2026
AstraZeneca’s investigational antibody-drug conjugate (ADC) sonesitatug vedotin (Sone-Ve) improved overall survival in patients with CLDN18.2-positive advanced gastric and gastroesophageal junction cancers.
Evaluated in the CLARITY-Gastric01 Phase 3 trial, Sone-Ve is the first CLDN18.2-targeted ADC to demonstrate positive survival benefit in this setting, highlighting the continued momentum behind targeted ADC approaches in precision oncology.
Read more here: https://www.onclive.com/view/sonesitatug-vedotin-improves-overall-survival-in-second--and-later-line-cldn18-2-positive-gastric-gej-cancer
Sonesitatug vedotin improved overall survival in pretreated CLDN18.2-positive advanced gastric/GEJ cancers in the phase 3 CLARITY-Gastric01 trial.