Real-World Evidence Circles

10/29/2026

𝗧𝗵𝗲 𝗯𝗲𝘀𝘁 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗿𝗮𝗿𝗲𝗹𝘆 𝗰𝗼𝗺𝗲 𝗳𝗿𝗼𝗺 𝗮 𝘀𝗶𝗻𝗴𝗹𝗲 𝗽𝗿𝗮𝗰𝘁𝗶𝗰𝗲.

They emerge when physicians pool knowledge and learn from a broader patient population. The Wickline/Mercuri TKA Circle now includes 𝟭𝟰 𝗶𝗻𝘃𝗲𝘀𝘁𝗶𝗴𝗮𝘁𝗼𝗿𝘀 contributing outcomes and clinical data from real-world knee replacement patients. Together, they’ve documented an average 𝟭𝟴.𝟯𝟯-𝗽𝗼𝗶𝗻𝘁 𝗶𝗺𝗽𝗿𝗼𝘃𝗲𝗺𝗲𝗻𝘁 𝗶𝗻 𝗞𝗢𝗢𝗦 𝗝𝗥 𝘀𝗰𝗼𝗿𝗲𝘀 𝘄𝗶𝘁𝗵𝗶𝗻 𝘀𝗶𝘅 𝘄𝗲𝗲𝗸𝘀 𝗮𝗳𝘁𝗲𝗿 𝘀𝘂𝗿𝗴𝗲𝗿𝘆.

This finding raises important questions: What are these patients doing differently? What can clinicians learn from their recovery journeys? And how can those lessons be applied more broadly?

The larger the network of participating physicians, the greater the opportunity to identify patterns that might otherwise remain invisible. Better outcomes don't happen simply because data is collected. They happen when clinicians learn from the data together.

But there’s another critical dimension: who actually owns that progress?

Too often, valuable clinical insights are absorbed by third-party platforms without any return to the practices that generate them. With the Wickline/Mercuri Circle, participating physicians retain full sovereignty over their clinical data—including the ability to share in dataset licensing and monetization.

By building this network together, we aren’t just advancing orthopedic science. We are creating a high-value, physician-owned dataset that is both a clinical asset and an economic one.

That’s where collaboration becomes both progress and enterprise.

Comment below or send us a message to learn how to join, retain your data rights, and contribute to the Circle.

10/28/2026

Ethics isn't a cost of doing business. It's becoming a competitive advantage.
As healthcare organizations invest in AI, , and advanced analytics, trust is emerging as a key differentiator. The organizations that prioritize transparency, accountability, and responsible innovation will be the ones best positioned to succeed.

Read our latest perspective on why ethics belongs in every growth strategy: https://www.rgnmed.com/post/ethics-as-a-competitive-advantage

Ethics is a competitive edge in healthcare data. See how embedded transparency and verifiable integrity build lasting trust and market resilience.

10/22/2026

Most organizations don't discover data problems until it's too late.

See why the future of healthcare depends on making data trustworthy from the moment it's collected.
Read more: https://www.rgnmed.com/post/data-integrity-by-design

Circle builds data integrity into healthcare architecture, with cryptographic proof and immutable audit trails that make compliance native.

10/20/2026

𝐂𝐌𝐒 𝐞𝐯𝐚𝐥𝐮𝐚𝐭𝐞𝐬 𝐒𝐮𝐛𝐬𝐭𝐚𝐧𝐭𝐢𝐚𝐥 𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐁𝐞𝐧𝐞𝐟𝐢𝐭 𝐚𝐭 𝟏𝟐 𝐦𝐨𝐧𝐭𝐡𝐬. 𝐌𝐎𝐓𝐈𝐕™ 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐫𝐞𝐚𝐜𝐡𝐞𝐝 𝐢𝐭 𝐢𝐧 𝟗𝟎 𝐝𝐚𝐲𝐬.

Surgeons and facilities face mounting regulatory pressures under the mandatory THA/TKA PRO-PM. Our live registry demonstrates what happens when high-performing surgical pathways meet standardized data capture:

𝐏𝐫𝐞-𝐎𝐩: 52.7 (n =362)
𝟐 𝐖𝐞𝐞𝐤𝐬: 65.4 (n = 292) | +𝟏𝟐.𝟕 𝐩𝐭𝐬 (immediate MCID)
𝟔 𝐖𝐞𝐞𝐤𝐬: 70.2 (n = 242) | +𝟏𝟕.𝟓 𝐩𝐭𝐬 (bordering CMS PASS ≥ 71)
𝟑 𝐌𝐨𝐧𝐭𝐡𝐬: 74.0 (n = 172) | +𝟐𝟏.𝟑 𝐩𝐭𝐬 (surpasses CMS 1-yr SCB ≥ 20)
𝟔 𝐌𝐨𝐧𝐭𝐡𝐬: 75.3 (n = 49) | Sustained functional plateaus

𝐓𝐡𝐞 𝐌𝐎𝐓𝐈𝐕™ 𝐏𝐫𝐨𝐭𝐨𝐜𝐨𝐥 & 𝐏𝐫𝐚𝐜𝐭𝐢𝐜𝐞 𝐁𝐨𝐭𝐭𝐨𝐦 𝐋𝐢𝐧𝐞:

Co-authored by Drs. Andrew Wickline and John J. Mercuri, expert-reviewed by Orthopaedic Research and Education Foundation, and published in , the ™ protocol is product-agnostic. While we are still investigating which specific clinical and perioperative variables drive this early acceleration, capturing standardized is vital to elevate care for all patients.

✔️ 𝐃𝐞-𝐑𝐢𝐬𝐤𝐢𝐧𝐠 𝐂𝐌𝐒 𝐑𝐞𝐢𝐦𝐛𝐮𝐫𝐬𝐞𝐦𝐞𝐧𝐭𝐬: Avoid the 25% Medicare APU penalty. While 1-year survey attrition remains a massive liability, MOTIV™ maintains >𝟗𝟎% 𝐜𝐨𝐦𝐩𝐥𝐢𝐚𝐧𝐜𝐞 𝐚𝐜𝐫𝐨𝐬𝐬 𝐚𝐜𝐭𝐢𝐯𝐞 𝐭𝐢𝐦𝐞𝐩𝐨𝐢𝐧𝐭𝐬, with patients clearing the CMS 1-year clinical benchmark in just 90 days.

✔️ 𝐓𝐫𝐮𝐞 𝐃𝐚𝐭𝐚 𝐎𝐰𝐧𝐞𝐫𝐬𝐡𝐢𝐩: Physicians retain 100% data ownership to build practice equity and support future RWE monetization.

Learn more about the MOTIV™ protocol and how to participate: https://www.rgnmed.com/motiv

(𝘐𝘯𝘵𝘦𝘳𝘪𝘮 𝘶𝘯𝘢𝘥𝘫𝘶𝘴𝘵𝘦𝘥 𝘢𝘯𝘢𝘭𝘺𝘴𝘪𝘴 𝘰𝘧 𝘳𝘰𝘭𝘭𝘪𝘯𝘨 𝘳𝘦𝘨𝘪𝘴𝘵𝘳𝘺 𝘤𝘰𝘩𝘰𝘳𝘵. 𝘋𝘢𝘴𝘩𝘣𝘰𝘢𝘳𝘥 𝘤𝘩𝘢𝘳𝘵 𝘢𝘵𝘵𝘢𝘤𝘩𝘦𝘥.)

LINK TO MOTIV™ PROTOCOL:https://circles.rgnmed.com/hubfs/Unlisted%20Pages/MOTIV%20(OREF)/MOTIV%20Wickline-Mercuri%20TKA/Foundational/MOTIV%20Total%20Knee%20Arthroplasty%20Protocol%20PDF.pdf

10/13/2026

CMS bundled-payment mandates like CJR-X are not a pilot. They represent a strong trend, and are likely to extend to more procedures and therapeutic areas.

Beginning January 1, 2028, roughly 2,500 hospitals become accountable for a joint-replacement episode that runs from a 180-day pre-admission risk-adjustment lookback, through the acute stay, to 90 days after discharge. Covered hospitals face four challenges:

1. 𝗖𝗼𝘀𝘁 𝗮𝗻𝗱 𝗰𝗼𝗺𝗽𝗹𝗲𝘅𝗶𝘁𝘆. Monitoring every partner across that span (P*P, pre-op clinic, surgeon, SNF, home health) takes systems and IT infrastructure that are expensive to build and difficult to sustain. For many hospitals, building it internally is not realistic.

2. 𝗧𝗶𝗺𝗶𝗻𝗴. Even when the data can be assembled, it arrives too late. CMS's data feed and final reconciliation come after the performance year ends, when no corrective action remains.

3. 𝗢𝘂𝘁𝗰𝗼𝗺𝗲𝘀 𝗽𝗮𝗶𝗿𝘀. CJR-X scores patient-reported outcomes using matched surveys: one within 90 days before surgery, one 300 to 425 days after. Falling short of the minimum defaults that measure to a mediocre score. A low enough Composite Quality Score then forfeits the entire reconciliation payment, however well costs were managed. Separately, hospital-wide completion below 50% cuts the annual Medicare payment update.

4. 𝗙𝗿𝗮𝗴𝗺𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻. Each partner is responsible for one piece of pre-admission risk-adjustment lookback and the post-discharge care. No one has visibility into the entire episode while it is still running.

RegenMed's patented Circles Platform addresses this with a single architecture spanning pre-op, hospital, post-acute, and patient surveys. Hospitals see quality-score drivers and survey completion during the episode, at lower cost than attempting to assemble a number of point solutions.

More here: https://www.rgnmed.com/post/circles-platform-for-cjr-x

10/08/2026

What if the biggest barrier to improving outcomes isn’t surgery, but what happens after patients leave the hospital?

Healthcare has invested heavily in advancing implants, surgical robotics, and perioperative pathways. Yet one of the greatest challenges remains remarkably consistent:

𝐊𝐞𝐞𝐩𝐢𝐧𝐠 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐞𝐧𝐠𝐚𝐠𝐞𝐝 𝐥𝐨𝐧𝐠 𝐞𝐧𝐨𝐮𝐠𝐡 𝐭𝐨 𝐚𝐜𝐭𝐮𝐚𝐥𝐥𝐲 𝐥𝐞𝐚𝐫𝐧 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞𝐢𝐫 𝐫𝐞𝐜𝐨𝐯𝐞𝐫𝐲.

In a landmark total joint arthroplasty study published in The Journal of Arthroplasty (Sutton et al., Rothman Institute), institutional compliance rates highlighted this industry-wide struggle:

◾ Preoperative KOOS, JR. survey completion compliance rates reached only 65% across all knee patients.

◾ 1-year postoperative compliance dropped to 46% overall—despite nearly $1M invested in dedicated registry personnel, software, and outreach teams.

See also Morrell et al., reporting from the AJRR registry that "among 1,264,863 outpatient primary TKAs, 70,677 had linked baseline and 1-year PROMs" — 5.6%

In contrast the MOTIV™ TKA Circle — launched this past February and with 362 cases to date and increasing daily — is already demonstrating that compliance thresholds that once seemed unattainable in routine clinical practice are possible when patients are meaningfully engaged in their care. The MOTIV™ data, fully verifiable to ground truth sources, reflects that difference:

◾ 96% pre-op compliance
◾ 86% 6-month post-op compliance (with surveys still actively coming in)
◾ 90% overall protocol compliance (1,036 completed surveys out of 1,154 due across all active intervals)

Combined with a carefully pre-structured Observational Protocol, that level of participation creates something rare in : true visibility into which patients recover quickly, which interventions make a measurable difference, and where real opportunities exist to optimize care pathways.

For example, the MOTIV™ TKA Circle data is showing — again with full provenance — an average 18.33-point increase in KOOS, JR. scores within just six weeks of surgery, representing a roughly 20% improvement from baseline.

The functional improvement is exciting. But showing that high compliance can be sustained across real-world workflows without substantial longitudinal attrition is the foundational breakthrough. Because when patients stay engaged, they don't just provide numbers. They generate the insights that actively improve care for the patients who come next.

Learn more about the ™ project here: https://www.rgnmed.com/motiv

Link to Sutton et al article: https://www.arthroplastyjournal.org/article/S0883-5403(22)00896-8/fulltext

Link to Morrell et al.: https://www.sciencedirect.com/science/article/abs/pii/S0883540326002287

10/07/2026

Most healthcare organizations focus on innovation.

The bigger challenge? Replicating success.

A promising pilot, a breakthrough care model, or a new technology only creates lasting value when it can consistently deliver results across providers, patients, and settings. That's where the real economics begin.

Our latest article explores why replication, not innovation alone, may be the true driver of sustainable healthcare transformation.

What are the biggest barriers to replicating success in healthcare?

https://www.rgnmed.com/post/the-economics-of-replication

Replication sustains scientific trust but goes unfunded and unrewarded. See what incentives could make verification pay.

10/05/2026

Healthcare is generating more data and research than ever before.

For clinical researchers and healthcare leaders, the challenge is no longer finding information. It's turning that information into meaningful evidence quickly enough to support better decisions.

AI is creating new opportunities to accelerate evidence synthesis, reduce manual effort, and help organizations move from questions to insights faster while maintaining scientific rigor.

As healthcare continues to evolve, the conversation is shifting from whether AI should support evidence generation to how it can be integrated responsibly and effectively.

Interested in discussing the future of AI-powered evidence generation and clinical research? Reach out to our team. We'd love to connect.

10/05/2026

Healthcare can't afford to wait months for answers.

As the volume of research continues to grow, AI is helping organizations accelerate evidence synthesis and turn information into action faster.

Explore how Evidence as a Service is reshaping the future of evidence generation and decision-making: https://www.rgnmed.com/post/evidence-as-a-service-compressing-the-synthesis-timeline-through-ai-integration

Accelerate clinical translation with Evidence-as-a-Service. Learn how AI and Circle Datasets compress systematic review timelines with 97% precision.

10/01/2026

Patient trust is becoming a competitive advantage.
As healthcare organizations pursue AI, research, and data-driven improvement, the ability to earn meaningful patient participation may matter more than the technology itself.

Our latest article explores why that creates a powerful Consent Dividend: https://www.rgnmed.com/post/the-consent-dividend

Circle Health Coins reward verified consent with recognition and financial yield, turning participation into equity.