LICORbio

LICORbio LICORbio is your constant in discovery. Achieve superior results using the Pearl® Trilogy imaging system & BrightSite™ near-infrared fluorescent probes.

LICORbio develops state-of-the-art imaging solutions integrated with dedicated reagents, powerful software and unmatched support to help scientists obtain reliable, quantitative research results. LI-COR Biosciences offers imaging systems, analysis software, and IRDye® infrared reagents for quantitative protein and small animal imaging.

Come join the community over on the LI-COR Odyssey Western Blotting page! We share tips for getting the best da...
11/24/2020

Come join the community over on the LI-COR Odyssey Western Blotting page! We share tips for getting the best data and meeting publishing and grant funding requirements. https://bit.ly/3lGrhGq

Are you doing therapeutic research or interested in proteomics? Give our other page a follow to see tips and gr...
11/18/2020

Are you doing therapeutic research or interested in proteomics? Give our other page a follow to see tips and great journal articles! https://bit.ly/3lGrhGq

Using multiple organ tissue section infrared imaging to evaluate and validate targeted therapeutic delivery. http://ow.l...
06/23/2020

Using multiple organ tissue section infrared imaging to evaluate and validate targeted therapeutic delivery. http://ow.ly/CDWv50AaymL

Optimization and Characterization of Protein Nanoparticles for the Targeted and Smart Delivery of Cytochrome c to Non-Small Cell Lung Carcinoma

"The presented experiments demonstrated that the tested strategy of folate receptor targeting using a core-shell NP loaded with pro-apoptotic protein Cyt c is an efficient method to deliver this drug and induce cell death in lung carcinoma cells."

Near-infrared fluorescence detection (680 nm to 820 nm) is a sensitive and efficient modality for in vivo studies. Find ...
06/09/2020

Near-infrared fluorescence detection (680 nm to 820 nm) is a sensitive and efficient modality for in vivo studies. Find out the advantages and switch to NIR. http://ow.ly/zDvD50zGd4z

Interesting paper looking at the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. http://...
06/04/2020

Interesting paper looking at the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. http://ow.ly/rIF950zMzGV

Highlights:
•SARS-CoV-2 infection induces low IFN-I and -III levels with a moderate ISG response
•Strong chemokine expression is consistent across in vitro, ex vivo, and in vivo models
•Low innate antiviral defenses and high pro-inflammatory cues contribute to COVID-19

Quantitative Western blotting was done using the LI-COR Odyssey Clx imager.

Biodistribution studies can identify regions and time of specific and non-specific retention of the probe in organs and ...
06/02/2020

Biodistribution studies can identify regions and time of specific and non-specific retention of the probe in organs and tissues. use NIR dye-labeled probes and the Pearl Trilogy imager for fast, reliable results. http://ow.ly/fIe450zGcMi

The method used in this paper is an excellent example of two target in-vivo imaging for simultaneously monitoring both i...
05/28/2020

The method used in this paper is an excellent example of two target in-vivo imaging for simultaneously monitoring both inflammation burden and microbial infection development and severity. http://ow.ly/uqRw50zQJRh

Inflammation was tracked via IRDye®800CW 2-deoxyglucose in the 800-nm fluorescent channel and P. aeruginosa Xen5 was visualized using the bioluminescent channel, both on the LI-COR Pearl In-vivo Imager.

The same concept could be applied to other areas of research including cancer therapeutics where tumor burden is measured using the bioluminescent channel and your targeted labeled therapeutic is tracked (biodistribution) in a fluorescent channel.

Learn how to maximize your targeted therapeutics research and make groundbreaking scientific advancements with NIR detec...
05/26/2020

Learn how to maximize your targeted therapeutics research and make groundbreaking scientific advancements with NIR detection and innovative probe development. http://ow.ly/48KC50zGcAJ

Are you trying to assess your therapeutic agent’s performance in vitro and ex vivo? Use the Odyssey CLx Imager for in vi...
05/19/2020

Are you trying to assess your therapeutic agent’s performance in vitro and ex vivo? Use the Odyssey CLx Imager for in vivo and ex vivo using the Pearl Trilogy Small Animal Imager. http://ow.ly/edtp50zGcvz

Decide which of your candidates appears most promising and move to the next step of validation.

An example of the work being done to understand the relationship of current therapeutics to the microbiome. Nice work ou...
05/14/2020

An example of the work being done to understand the relationship of current therapeutics to the microbiome. Nice work out of Université de Toulouse. http://ow.ly/bqJp50zGaNy

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