The Immunology Fraternity

11/21/2020

The Most Beautiful Experiment: Meselson and Stahl!
iBiology

www.iBiology.org Matt Meselson and Frank Stahl share the story of their groundbreaking experiment from 1958 that definitively showed semiconservative DNA rep...

10/30/2020

M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity

The pathogen Mycobacterium tuberculosis reprograms hematopoietic stem cells and limits myelopoiesis while impairing trained immunity responses via a type I IFN/iron signaling axis.

10/24/2020

The Yale Center for Immuno-Oncology Symposium!
View presentations from this year's Symposium!

Link:

The Yale Center for Immuno-Oncology Symposium was held virtually on October 16, 2020. View the agenda>> View presentations from this years Symposium (please note: Dr. Rafi Ahmed and Dr. Arlene Sharpe’s talks were not included due to preliminary data).

10/18/2020

09/16/2020

STRAND AT HOME - Virtual Cinema presents: PICTURE A SCIENTIST A feature-length documentary film chronicling the groundswell of researchers who are writing a ...

07/28/2020

https://www.nature.com/articles/s41587-020-0613-1

A system to express neoantigens in tumor cells and mice circumvents central T cell tolerance.

07/28/2020

https://www.nature.com/articles/s41422-020-0379-5

The maintenance of organismal homeostasis requires partitioning and transport of biochemical molecules between organ systems, their composite cells, and subcellular organelles. Although transcriptional programming undeniably defines the functional state of cells and tissues, underlying biochemical n...

07/28/2020

https://www.annualreviews.org/doi/10.1146/annurev-immunol-032414-112315

Mucosal surfaces provide a remarkably effective barrier against potentially dangerous pathogens. Therefore, enhancing mucosal immunity through vaccines—strengthening that first line of defense—holds significant promise for reducing the burden of viral diseases. The large and varied class of vira...

07/28/2020

https://science.sciencemag.org/content/early/2020/07/15/science.abc8511

COVID-19 is currently a global pandemic, but human immune responses to the virus remain poorly understood. We analyzed 125 COVID-19 patients, and compared recovered to healthy individuals using high dimensional cytometry. Integrated analysis of ~200 immune and ~50 clinical features revealed activati...

07/28/2020

https://www.cell.com/cell/fulltext/S0092-8674(20)30687-5

During acute psychological stress, brown adipocytes initiate a chain of events mediated by adrenergic signaling and IL-6 release that metabolically fuels “fight or flight” adaptive responses but at the same time comes at an inflammatory cost.

07/28/2020

https://www.nature.com/articles/s41586-020-2422-6

An engineered version of IL-18 that is resistant to binding by the soluble decoy receptor IL-18BP shows strong anti-tumour activity in mouse models of cancer.

07/28/2020

https://www.nature.com/articles/s41590-020-0706-5

Bcl-6 is the signature transcription factor for TFH cells. Crotty and colleagues provide a comprehensive transcriptional map depicting the regulatory circuitry controlled by Bcl-6 in determining TFH cell fate and function.