04/21/2025
Initial preclinical data from ATNM-400 will be presented at in Chicago on April 27, 2025, 2:00 pm – 5:00 pm CT.
Highlights from the abstract include:
• ATNM-400 selectively binds to prostate cancer cells, undergoes rapid internalization, and induces dose-dependent cytotoxicity.
• In prostate cancer xenograft mouse models, ATNM-400 accumulated in tumors for up to 144 hours, while showing minimal uptake in normal tissues.
• Small animal SPECT/CT imaging with Indium-111-labeled antibody confirmed selective tumor accumulation and clearance from healthy tissues.
• A single dose of ATNM-400 achieved 68.5% tumor growth inhibition at 20 µCi/kg and 99.8% at 40 µCi/kg, with all doses being well tolerated.
ATNM-400 AACR Presentation Details:
• Title: ATNM-400 is a novel Actinium-225 antibody radioconjugate with strong efficacy in preclinical models of prostate cancer
• Abstract Number: 578
• Session: PO.ET08.01 - Theranostics and Radiotheranostics
• Date & Time: April 27, 2025 – 2:00 pm – 5:00 pm CT
More details here: https://bit.ly/41OmjPt