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The authors developed a microfluidic device, FINDChip, to automate & enhance oocyte recovery from follicular fluid. In c...
04/13/2026

The authors developed a microfluidic device, FINDChip, to automate & enhance oocyte recovery from follicular fluid. In clinical settings, the device recovered oocytes missed during manual screening, increasing the number of viable oocytes for

Infertility is a global health challenge affecting millions worldwide, and in vitro fertilization (IVF) remains the main treatment option. The...

Long-term follow-up of participants in the ADVENT , comparing pulsed field ablation to conventional thermal ablation in...
04/06/2026

Long-term follow-up of participants in the ADVENT , comparing pulsed field ablation to conventional thermal ablation in patients with paroxysmal atrial fibrillation, shows preserved effectiveness of pulsed field ablation over 4y.

Pulsed field ablation (PFA) has proven to be a safe and effective non-thermal ablation modality for the treatment of atrial fibrillation (AF), but...

In a study of 4 brain-dead human decedents, extracorporeal liver cross-circulation using genetically-modified pig livers...
04/03/2026

In a study of 4 brain-dead human decedents, extracorporeal liver cross-circulation using genetically-modified pig livers provides evidence for provision of essential hepatic function, supporting its feasibility for temporary liver support.

Extracorporeal liver cross-circulation (ELC) using genetically modified pig livers may address an unmet need for temporary liver support in...

In a randomized controlled study of 1,298 participants, performance of humans when assisted by an was inferior to the ...
04/02/2026

In a randomized controlled study of 1,298 participants, performance of humans when assisted by an was inferior to the LLM alone when assessing 10 medical scenarios.

Global healthcare providers are exploring the use of large language models (LLMs) to provide medical advice to the public. LLMs now achieve nearly...

In a phase 2 trial, the live-attenuated Chikungunya Vaccine (VLA1553) was given to children < 12y old in Honduras & the ...
03/31/2026

In a phase 2 trial, the live-attenuated Chikungunya Vaccine (VLA1553) was given to children < 12y old in Honduras & the Dominican Republic, & was found to be safe & immunogenic.

Currently, no licensed vaccine is available against chikungunya virus (CHIKV) in children aged less than 12 years. In this phase 2, observer-blind,...

In a randomized study involving 9 general cardiologists & 107 patient cases, assistance from an led to preferable resp...
03/30/2026

In a randomized study involving 9 general cardiologists & 107 patient cases, assistance from an led to preferable responses on complex case management vs physicians alone.

The scarcity of subspecialist medical expertise poses a considerable challenge for healthcare delivery. This issue is particularly acute in...

In a case series of 8 pediatric patients with systemic lupus erythematosus, dermatomyositis or systemic sclerosis, autol...
03/27/2026

In a case series of 8 pediatric patients with systemic lupus erythematosus, dermatomyositis or systemic sclerosis, autologous anti-CD19 CAR-T cell therapy was feasible, safe & effective in reducing disease activity.

Chimeric antigen receptor (CAR) T cell therapy was recently proposed as a treatment for adults with B-cell-mediated autoimmune diseases (ADs)...

In the phase 1/2 TRIDENT-1 , treatment of patients with NRTK fusion–positive advanced solid tumors with repotrectinib l...
03/26/2026

In the phase 1/2 TRIDENT-1 , treatment of patients with NRTK fusion–positive advanced solid tumors with repotrectinib led to systemic & intracranial clinical response. .

Early-generation TRK tyrosine kinase inhibitors (TKIs) approved for treating NTRK fusion–positive (NTRK+) solid tumors provide clinical benefit;...

Elevated serum pTau levels are not specific to Alzheimer´s disease and may also serve as diagnostic tool for the most co...
03/25/2026

Elevated serum pTau levels are not specific to Alzheimer´s disease and may also serve as diagnostic tool for the most common types of systemic amyloidosis, with potential utility in distinguishing amyloidosis-related polyneuropathy from polyneuropathy of other etiologies

Elevated blood levels of phosphorylated tau (p-tau) are diagnostic of Alzheimer disease and are associated with the deposition of amyloid-β in the...

The phase 2/3 DEVOTE demonstrated that high-dose nusinersen improved motor function & was safe in patients with spinal...
03/25/2026

The phase 2/3 DEVOTE demonstrated that high-dose nusinersen improved motor function & was safe in patients with spinal muscular atrophy, vs a matched sham control.

Despite the remarkable benefits of nusinersen and other disease-modifying therapies in spinal muscular atrophy (SMA), patients may still experience...

Global cancer estimates across 185 countries show that 7.1 million new cancer cases were attributable to 30 modifiable r...
03/24/2026

Global cancer estimates across 185 countries show that 7.1 million new cancer cases were attributable to 30 modifiable risk factors in 2022, with smoking, infections & alcohol consumption leading contributors to cancer burden.

Global cancer estimates across 185 countries show that 7.1 million new cancer cases were attributable to modifiable risk factors in 2022, with...

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