Nature Medicine

08/31/2026

As presented at the 2026 ESC Congress, use of direct oral anticoagulants together with potent P2Y12 inhibitors in patients with atrial fibrillation and acute coronary syndrome was associated with higher bleeding rates without evidence of reduced ischemic events, as compared to direct oral anticoagulants together with clopidogrel and aspirin.

As presented at the 2026 European Society of Cardiology Congress, use of direct oral anticoagulants together with potent P2Y12 inhibitors in patients with atrial fibrillation and acute coronary syndrome was associated with higher bleeding rates without evidence of reduced ischemic events, as compare...

08/31/2026

As presented at the 2026 ESC Congress, in a secondary analysis of the CARDIOTTRansform trial testing the transthyretin-targeting antisense oligonucleotide eplontersen in patients with transthyretin amyloid cardiomyopathy, a beneficial effect was observed in patients who were not on transthyretin stabilizers at baseline, but not in those who were on stabilizers.

As presented at the 2026 ESC Congress, in a secondary analysis of the CARDIOTTRansform trial testing the transthyretin-targeting antisense oligonucleotide eplontersen in patients with transthyretin amyloid cardiomyopathy, a beneficial effect was observed in patients who were not on transthyretin sta...

08/31/2026

A cross-trial analysis using data from 38,753 participants across nine trials estimates effects of comprehensive medical therapy for heart failure on blood pressure, kidney function, and potassium levels, potentially guiding safer therapy initiation.

A cross-trial analysis using data from 38,753 participants across nine trials estimates effects of comprehensive medical therapy for heart failure on blood pressure, kidney function and potassium levels, potentially guiding safer therapy initiation.

08/28/2026

A new trial on -assisted therapy for treatment-resistant shows promising adherence and safety. It also raises questions about access, treatment locations, and necessary standards for sustainability. News & Views from Liliana Galindo & colleagues:

A feasibility trial delivering psilocybin-assisted therapy for treatment-resistant depression within the UK health service reports encouraging adherence and safety — it opens future questions about who is reached, where treatment happens and what standards will be needed to sustain it.

08/28/2026

Liver DiagnOsis Network (LiON), a contrast enhanced-CT-based AI system that supports flexible multiphase processing, clinical-data integration and workflow-compatible liver malignancy diagnosis, may help reduce missed or delayed diagnoses and guide clinical interventions.

Liver DiagnOsis Network (LiON), a contrast-enhanced-computed tomography-based AI system that supports flexible multiphase processing, clinical data integration and workflow-compatible liver malignancy diagnosis, may help reduce missed or delayed diagnoses and guide clinical interventions.

08/28/2026

A pilot implementation study of a large-language model clinical decision support system in a tertiary emergency department showed safe integration but steadily declining clinical adoption over four weeks.

A pilot implementation study of a large language model clinical decision support system in a tertiary emergency department showed safe integration but steadily declining clinical adoption over 4 weeks.

08/27/2026

The Global Neurosurgical Study‑1 (GNS‑I), conducted across 100 hospitals in 29 countries, found substantial variation in the causes of traumatic brain injury and in associated mortality outcomes across human‑development index tiers.

The Global Neurosurgical Study-1 (GNS-I), conducted across 100 hospitals in 29 countries, found substantial variation in the causes of traumatic brain injury and in associated mortality outcomes across Human Development Index tiers.

08/27/2026

Whole-side histopathological images from 40 tissue types reveal morphological changes associated with aging, which when paired with transcriptomic data from blood, is used to develop aging clocks that reflect tissue structural integrity and organ-level physiological fitness in health and disease.

08/27/2026

Whole-side histopathological images from 40 tissue types reveal morphological changes associated with aging, which when paired with transcriptomic data from blood, is used to develop aging clocks that reflect tissue structural integrity and organ-level physiological fitness in health and disease.

Whole-slide histopathological images from 40 tissue types reveal morphological changes associated with aging, which, when paired with transcriptomic data from blood, are used to develop aging clocks that reflect tissue structural integrity and organ-level physiological fitness in health and disease.

08/27/2026

In an early-stage randomized trial, the safety and efficacy of intramyocardial injection of hiPSC-derived cardiomyocytes in patients with advanced heart failure were evaluated.

In an early-stage randomized trial, the safety and efficacy of intramyocardial injection of hiPSC-derived cardiomyocytes in patients with advanced heart failure were evaluated.