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Monday 8am - 5pm Tuesday 8am - 5pm Wednesday 8am - 5pm Thursday 8am - 5pm Friday 8am - 5pm

Crown Bioscience

Name: Crown Bioscience
Address: 16550 West Bernardo Drive, San Diego, CA, 92127, US
Telephone: +18586222900
Price range: $

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Crown Bioscience

A range of biomarker analysis and applied genomics services are also available to optimize therapeutic benefit. Find out more: www.crownbio.com

Crown Bioscience, a JSR Life Sciences company, is a global contract research organization (CRO) dedicated to accelerating drug discovery and development in oncology and immuno-oncology. Crown Bioscience, a JSR Life Sciences company, is a global contract research organization (CRO) providing discovery, preclinical, and translational platforms to advance oncology and immuno-oncology. Known for their

high quality and expansive in vivo, in vitro and ex vivo preclinical models, they partner with their clients to quantify the efficacy and pharmacological profile of their drug candidate before they move into the clinic. The company is the only preclinical CRO to provide tumor organoid services utilizing HUB technology and has the world’s largest commercially available PDX collection. Additionally, further services available in the areas of high content imaging and a 3D Ex Vivo Patient Tissue Platform, provide greater insights into complex disease pathophysiology. Crown Bioscience helps to deliver superior drug candidates to ensure that patients get the right treatment at the right time. Founded in 2006, Crown Bioscience has 12 facilities in the US, Europe, and APAC.

05/29/2026

Intrapatient organoid models can provide a more accurate recapitulation of corresponding parental tumors, supporting more translationally relevant in vitro research.

This month, we’re highlighting PA20006B, a primary-site pancreatic organoid model derived from a patient sample.

Use models like PA20006B to help recapitulate key characteristics of parental tumors and support more informed evaluation of tumor biology and therapeutic response.

Explore PA20006B and other available models in the Crown Bioscience databases: https://hubs.la/Q04jrBC00

05/27/2026

Looking for the best customer experience available in the industry? Explore our monthly Customer Satisfaction Report: https://hubs.la/Q04h_TpR0

05/26/2026

How do we enable deeper insights into CAR-T efficacy within complex tumor microenvironments? Our AACR 2026 Poster demonstrates how organoid fibroblast co-culture systems, combined with high-content imaging (HCI), improve the assessment of tumor killing, immune infiltration and resistance mechanisms.

See how this approach bridges the gap between mechanistic insights and translational relevance in immuno-oncology: https://hubs.la/Q04hSF-p0

05/22/2026

Crown Bioscience will be attending the 74th ASMS Conference on Mass Spectrometry and Allied Topics in San Diego.

We look forward to connecting with industry colleagues to discuss the latest advances supporting bioanalysis, translational research and drug development.

If you’re attending, schedule a meeting with Chengfei Ruan to learn more about how Crown Bioscience can support your research programs.

Schedule a meeting: https://hubs.la/Q04htc3X0

05/21/2026

How do you accurately predict clinical outcomes? By bridging the gap between drug concentration and biological effect.

In this on-demand webinar, Rekha Pal, PhD, provides a masterclass in integrating pharmacokinetics (PK) with pharmacodynamics (PD) to transform raw data into a roadmap for candidate success.

From mechanistic modeling to risk mitigation, see how early PK/PD integration can accelerate your transition from bench to clinic.

Watch now: https://hubs.la/Q04hsdTt0

05/20/2026

We’re pleased to share a new publication in Frontiers in Immunology:

“Translational 3D in vitro models for immunotherapy testing: from reconstituted organoid co-culture assays to autologous ex vivo patient tissues”

This study highlights how advanced organoid-based 3D in vitro platforms can improve the translational relevance of immunotherapy testing by more accurately modeling the tumor microenvironment.

The paper presents data from several T cell engagers and demonstrates how these platforms enable clinically relevant tumor microenvironment modeling, high-content multiparametric imaging, and assessment of immune cell infiltration, activation, and tumor killing across multiple immuno-oncology modalities, including ICIs, BiTEs, and CAR-T cell therapies.

These translational models can help generate more informative preclinical data and better support immuno-oncology drug development.

Read the full publication: https://hubs.la/Q04h4gvl0

05/19/2026

Did you know skin cancer is the most common type of cancer in the US? ¹ This Skin Cancer Awareness Month, we’re highlighting research advancements in melanoma cancer treatment.

Much progress has been made in treating people with melanoma and researchers are continuing to explore ways to make these treatments more effective for more patients, including through:

➡️ Targeted therapies using drug combinations

➡️ Immunotherapy, like immune checkpoint inhibition

➡️ Adoptive cell therapy, like tumor-infiltrating lymphocyte (TIL) therapy

Learn more about advances in melanoma and other skin cancers research: https://www.cancer.gov/types/skin

Make sure to follow us as we continue to share some our latest melanoma research and more.

¹https://hubs.la/Q04h4byp0

05/18/2026

Oncology researchers frequently struggle with the poor predictability of traditional xenografts. Why? Because these models don’t accurately reflect human tumor biology and clinical response.

Our patient-derived xenograft (PDX) mouse models mimic human tumor biology accurately – enhancing clinical translation and improving the precision of personalized treatment strategies.

See how our PDX MCTs increase the likelihood of success in clinical trials: https://hubs.la/Q04gyyr_0

05/15/2026

From target validation and biomarker discovery to hypothesis testing and AI/ML model development, Crown Bioscience Data Licensing empowers confident decision-making during oncology drug discovery.

With access to high-quality preclinical and translational oncology datasets – including in vivo study data and biomarker-rich molecular profiling – researchers can save time, reduce variability and accelerate insights.

Discover more: https://hubs.la/Q04gx2K30

05/14/2026

Crown Bioscience’s Model of the Month, CR9831, is a colorectal cancer PDX derived from a heavily pretreated patient, featuring prior exposure to an anti-c-MET ADC (ABBV-400).

With confirmed pathology (moderately differentiated adenocarcinoma, P2) and full multi-omics coverage (RNA-seq, exome-seq, WGS), CR9831 is built to power:
✔ ADC development
✔ Resistance mechanism studies
✔ Translational oncology research

ADC pretreated PDX models are rare and critical for advancing next generation targeted therapies.

Partner with us to access models that mirror today’s clinical landscape.
https://hubs.la/Q04gwqmz0

Address

16550 West Bernardo Drive
San Diego, CA
92127

Opening Hours

Monday	8am - 5pm
Tuesday	8am - 5pm
Wednesday	8am - 5pm
Thursday	8am - 5pm
Friday	8am - 5pm

Telephone

+18586222900

Website

http://www.crownbio.com/

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