Dovetail Genomics

08/31/2026

What if one of our best tools for preventing extinction is hidden inside the species themselves?

From sharks to butterflies, chromosome-level genomes are giving conservationists a clearer picture of genetic diversity, inbreeding, and population health - while there’s still time to act.

Read the full blog: https://na2.hubs.ly/H07w3-p0

08/27/2026

SV SPOTLIGHT: Structural variants, like other genetic variants, can be either germline or somatic.

Germline variants are inherited, while somatic variants arise during life. Understanding the difference can be critical for assessing disease risk, cancer diagnosis, and treatment decisions.

Learn more about it here: https://na2.hubs.ly/H07qgQq0

08/20/2026

SV SPOTLIGHT: Structural variants can do more than alter DNA, they can rewire gene regulation and help drive cancer.

Learn more about it here: https://na2.hubs.ly/H079XhD0

08/18/2026

Our team had an incredible time at AACR 2026!

Check out our latest blog for highlights from AACR and a look back at our time in San Diego: https://na2.hubs.ly/H079_V30

Discover how AACR 2026 highlighted advances in structural variant detection, ecDNA, linked-read sequencing, FFPE analysis, and 3D genome analysis.

08/11/2026

A new assay is only as convincing as its data. So here's what the Dovetail® FFPE Assay actually shows: Head-to-head comparisons show that FFPE-derived results detect structural variants with high concordance to matched fresh frozen tissue, in both breakpoint precision and VAF estimation.

Performance has been validated across multiple tumor types including breast, ovarian, and osteosarcoma samples. Critically, this includes samples with varying DIN scores and tumor fractions — the kind of real-world FFPE material that causes problems for other NGS platforms.

The Dovetail® FFPE assay is available as a kit for in-house library preparation, or as a service if you'd prefer to outsource the wet lab. Either way, data analysis runs through the Dovetail Analysis Portal — so you get consistent, actionable results without building custom bioinformatics pipelines.

The data speaks for itself.

🔗 Explore the data: https://na2.hubs.ly/H075_7J0

08/06/2026

📚 From the Literature: Exploring Regeneration in Jellyfish 🪼

🎉 Congratulations to Yiqian Li, Sean T.S. Law, Wenyan Nong, Jerome H.L. Hui, and colleagues on their publication in Molecular Biology and Evolution exploring tissue remodeling and regeneration in two species of true jellyfish.

Using single-cell RNA sequencing, the team profiled bell tissue remodeling and regeneration in the Asian moon jellyfish, Aurelia coerulea, and the flame jellyfish, Rhopilema esculentum. They identified 12 cell populations in each species and uncovered conserved, sequential changes during remodeling and regeneration, with proliferative, gastrodermal, neural, and secretory gland cells active early in the process, followed by cnidocytes in a later phase. The study also identified conserved transcription factors and signaling pathways associated with tissue remodeling and regeneration, including Otx, TFAP2A, Erg, NFIA, and Wnt/β-catenin signaling.

🧬 To support these analyses, the researchers generated a new Aurelia genome assembly using PacBio HiFi and Dovetail Omni-C data. The improved assembly significantly increased sequence continuity and enabled mapping rates of approximately 90–92% for the single-cell RNA-seq reads, providing a stronger genomic foundation for the study. Dovetail Genomics also contributed directly to the genome assembly and sequencing workflow.

👏 We're proud to have supported this work and excited to see Dovetail technologies helping researchers uncover the cellular and molecular basis of regeneration in understudied marine organisms.

🔗 Read the publication:

Abstract. The phylum Cnidaria is the outgroup of Bilateria and includes sea anemones, corals, hydroids, and jellyfish. Cnidarians play crucial ecological r

08/04/2026

📖 Customer Publication Highlight

🎉 Congratulations to Gonzalo Sabarís, Marco Di Stefano, Bernd Schuettengruber, Giacomo Cavalli, and colleagues on their recent publication in Nucleic Acids Research!

In this study, the authors investigated how Polycomb response elements (PREs) establish specific chromatin loops that regulate gene expression during development. Their findings reveal that while high GAF occupancy is required for robust PRE looping, GAF alone is not sufficient. Instead, chromatin loop specificity appears to depend on a combinatorial set of looping factors, supporting the idea that these combinations may form a molecular "code" that helps determine which PREs interact. The study also challenges previous models by showing that Polycomb Repressive Complex 1 (PRC1) is dispensable for local PRE loop formation, despite its association with these regions.

🧬 Using the Dovetail Micro-C Kit, the team generated high-resolution chromatin interaction maps that enabled them to quantify PRE looping across multiple genetic perturbations and support their mechanistic conclusions.

👏 We're proud that Dovetail Micro-C contributed to this important work and excited to see researchers advancing our understanding of 3D genome organization, chromatin architecture, and gene regulation.

🔗 Read the publication:

Abstract. Chromatin looping between cis-regulatory elements is essential for precise developmental gene expression, and its disruption is frequently linked

07/28/2026

📖 Customer Publication Highlight

Researchers generated 20 near-complete haplotype-phased assemblies from 10 Japanese individuals, providing a more complete view of medically relevant complex genomic regions that have historically been difficult to assemble and analyze.

By combining Dovetail Omni-C technology, PacBio HiFi, and ONT ultra-long reads, the team achieved chromosome-scale, haplotype-resolved assemblies with contig NG50 values exceeding 100 Mb. Their work substantially improved reconstruction of challenging regions—including KIR and SMN—and identified previously unresolved haplotypes and putative gene conversion events, advancing our understanding of human genomic diversity and medically relevant structural variation.

Congratulations to Yoshihiko Suzuki, Shinichi Morish*ta, and all of the co-authors on this outstanding work. We're excited to see Omni-C supporting high-quality genome assembly and pangenome research alongside complementary long-read sequencing technologies.

🔗 Read the publication:

A Japanese human pangenome graph built from near-complete genomes brings medically important blind spots of the human genome into focus, revealing hidden diversity in complex genomic regions related to immunity and disease.

07/23/2026

Most cancer genomics labs rely on multiple assays to build a comprehensive picture of somatic variation. This is not a process most labs happily choose. It's because no single technology has consistently captured the full spectrum of somatic variants with high performance.

Dovetail's linked-read approach changes that. It enables detection of SNVs, INDELs, CNVs, and SVs from a single library, running on your existing short-read sequencing platform. The workflow is compatible with both fresh-frozen and FFPE samples.

Importantly, this isn't a trade-off. You retain the strengths of conventional whole-genome sequencing for SNV, INDEL, and CNV detection while gaining highly sensitive SV detection.

If your current workflow requires stitching together multiple assays to cover the somatic variant landscape, this is worth a look.

See how the single-assay workflow works: https://na2.hubs.ly/H06R2j-0

07/22/2026

This week, we brought together our APAC distributor partners in beautiful Bali for the Dovetail Genomics APAC Distributor Meeting 2026. 🌏

Over two days, we shared product updates, exchanged insights from across the region, celebrated successes, and aligned on how we can better support the research community in the year ahead.

Our distributor partners are much more than a sales network—they are trusted collaborators who help bring Dovetail technologies to researchers worldwide, providing the local expertise and support that enable scientific discovery.

A special congratulations to Tomy Digital Biology, our Best Performing Distributor of 2025! 🎉

To all of our APAC partners, thank you for your dedication, expertise, and continued collaboration. 🤝 Your commitment helps extend the reach of our technologies and empowers researchers tackling some of the most important questions in genomics. 🧬

Here's to another exciting year of working together to advance genomics research.