Welch Materials, Inc.

06/12/2026

Chiral chromatography plays a key role in modern chemical synthesis, particularly where enantiomeric purity is paramount. Many of synthetic intermediates posses one or more chiral centers, produced as racemates.

Even when the target molecule is not itself the final active ingredient, the stereochemical purity of an intermediate can strongly influence yield, impurity profile, reaction selectivity, and regulatory compliance.

In this article, we present application notes of five typical synthetic intermediates, witnessing how Blossmate chiral columns successfully separate them from their enantiomers.

Read the article: https://www.welch-us.com/blogs/knowleage-base/advanced-chromatographic-resolution-of-chiral-compounds-part-vi-intermediates

06/05/2026

A special gift to the upcoming CPHI & PMEC China 2026 exhibition in Shanghai from Welch Materials!

To celebrate this premier industry gathering, we are bringing a special highlight to our booth: the Welch Chromatography Column Plush Blind Box. This creative item will be gifted to our exhibition visitors at our booth W15B11.

🎬 Watch the video below for a preview of the different collectible plush designs included in the blind boxes. (Each box contains a random one!)
📍 Exhibition Venue: Shanghai New International Expo Center (SNIEC)
📅 Dates: June 16–18, 2026
📍 Booth W15B11

Note: The quantity of blind boxes reserved for the exhibition is limited. We encourge you to plan your visit to our booth early to secure yours.

06/03/2026

In High-Performance Liquid Chromatography (HPLC), columns are high-cost core consumables. Premature column failure compromises data reproducibility and disrupts laboratory workflows in addition to escalating operational costs.

While columns inevitably degrade over time due to normal wear, a substantial number of failures stem from improper handling and operational errors.

In this article, we introduce five foundational rules, and explain why they safeguard your HPLC columns from being retired too early.

Read on our website: https://www.welch-us.com/blogs/knowleage-base/maximizing-longevity-five-practical-ways-to-extend-hplc-column-life

Learn the five essential and practical rules to extend HPLC column life: follow the column's pH range, filter before injection, use guard columns, and so on.

06/02/2026

Welch Materials will be at 2026 in !

Join our team of chromatography experts to explore our latest innovations, including our industry-leading HPLC & GC columns, advanced Chiral stationary phases, and high-performance preparative systems designed to streamline your laboratory workflows and manufacturing scale-up.

Date: June 16—18, 2026
Location: New International Expo Center, Shanghai, China
Booth: W15B11

Schedule a meeting with our team ahead of time or drop by Booth W15B11. See you in Shanghai!

05/29/2026

What an incredible event at Asia Labex 2026!

The whole event was filled with meaningful interactions, exciting discussions, and an overwhelming number of customer visits at the Welch Materials booth, which we recorded in this 2-minute video.

Thank you to all our colleagues devoting their time to the event, and to everyone who visited us at the event! We look forward to connecting with you again in our future exhibitions!

Watch the video: https://youtu.be/T_c8tnTIa-Y

What an incredible response at Asia Labex 2026!The whole event wa...

05/29/2026

has always been one of the greatest challenges in analytical chemistry. Many of us dream of obtaining chromatograms that are as "clean and beautiful" as reference standards, but the reality is often harsh.

In this article, we discuss about extraction in sample preparation. We compare the characteristics, disadvantages, and target applications of Solid-Phase Extraction ( ), dispersive SPE (e.g. ), and Liquid-Liquid Microextraction ( ).

Read the article: https://welchlab.com/blogs/news/an-overview-of-different-extraction-methods-in-sample-preparation-and-their-characteristics

05/26/2026

In modern pharmaceutical development, more than half of the APIs currently synthesized and marketed possess one or more chiral centers. If they are not separated properly during production, not only the drug efficacy is hindered, but also they may become toxic.

In this article, we present application notes on the chiral separation of five distinct APIs, using various Welch Blossmate chiral stationary phases.

Read the article: https://www.welch-us.com/blogs/knowleage-base/advanced-chromatographic-resolution-of-chiral-compounds-part-v-apis

05/21/2026

In chromatographic analysis, achieving high sensitivity and selectivity for trace-level analytes within complex matrices is a foundational challenge towards accurate determination.

Photochemical post-column derivatization utilizes high-intensity UV light as a clean, reagent-free catalyst, addressing operational drawbacks from electrochemical post-column derivatization, enhancing the response of target analytes under fluorescence, UV, electrochemical, and chemiluminescence detection.

The Photo Chemical Reactor developed by Welch Materials, featuring a color display for instrument status monitoring, UV lamp fault detection and leak alarm functions, significantly improving derivatization performance in aflatoxin analysis, sulfonamide drug analysis, etc.

Read more about the device with example applications: https://www.welch-us.com/blogs/knowleage-base/welview-photo-chemical-reactor

05/18/2026

Isomer separation is one of the most challenging tasks in chromatography. Due to the similarities in structure, isomers, especially positional isomers, often possess nearly identical partition coefficients.

In this article, we evaluate the chromatographic performance of three Welch Materials’ Ultisil stationary phases—PFP, Alk-C18, and XS-C18—on the separation of isomeric derivatives and analogs of antharaquinone.

Explore and witness which of them shows the optimal performance: https://www.welch-us.com/blogs/knowleage-base/a-comparison-of-welch-ultisil-columns-on-the-isomeric-separation-of-anthraquinones

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05/15/2026

𝗔𝗻𝘁𝗶𝗯𝗼𝗱𝘆-𝗗𝗿𝘂𝗴 𝗖𝗼𝗻𝗷𝘂𝗴𝗮𝘁𝗲𝘀 (𝗔𝗗𝗖𝘀) is a complex class of targeted cancer therapeutics which consist of three integral components: an antibody, a chemical linker, and a potent cytotoxic payload.

In the analysis of ADCs, the number of payloads one carries, or to say the 𝗗𝗿𝘂𝗴-𝘁𝗼-𝗔𝗻𝘁𝗶𝗯𝗼𝗱𝘆 𝗥𝗮𝘁𝗶𝗼 (𝗗𝗔𝗥) is a critical quality attribute we pay great attention to, as it determines the drug's "firepower".

In order to determine the DAR value of an ADC drug "gently" without harming the ADC's conformation (like what RP-HPLC does), 𝗛𝘆𝗱𝗿𝗼𝗽𝗵𝗼𝗯𝗶𝗰 𝗜𝗻𝘁𝗲𝗿𝗮𝗰𝘁𝗶𝗼𝗻 𝗖𝗵𝗿𝗼𝗺𝗮𝘁𝗼𝗴𝗿𝗮𝗽𝗵𝘆 (𝗛𝗜𝗖), which separates species based on the varying degrees of hydrophobicity, is employed.

Read the article to learn how HIC determines the DAR distribution 𝗿𝗲𝗹𝗶𝗮𝗯𝗹𝘆, and 𝘄𝗵𝗮𝘁 𝘁𝗼 𝗼𝗽𝘁𝗶𝗺𝗶𝘇𝗲 when developing an HIC-based ADC analysis method:
https://www.welch-us.com/blogs/knowleage-base/hydrophobic-interaction-chromatography-your-best-teammate-in-the-analysis-of-adcs