Chemical Microscopy LLC

05/01/2026

Our latest article

The structure of nirmatrelvir MTBE solvate, C23H32F3N5O4·C5H12O, at 150 K has monoclinic (P21) symmetry. The asymmetric unit contains one nirmatrelvir mol­e ...

09/30/2025

We're now a Sustaining Member!

Chemical Microscopy is now a Sustaining Member of Microscopy Society of America (MSA) and being recognized in the controlled-circulation trade magazine Microscopy Today, Volume 33, Number 4, 2025 July

11/20/2024

Please join us at this online symposium.

Emerging Trends in Pharmaceutical and Biopharmaceutical Analysis

What are the cutting-edge techniques shaping biopharmaceutical and pharmaceutical development today? This two-day event, hosted by Spectroscopy, the Coblentz Society, and the Society for Applied Spectroscopy, will dive into the latest breakthroughs transforming both biomedicine and drug development. Hear from leading companies and researchers as they showcase the newest innovations driving the future of pharmaceutical and biopharmaceutical research, with a focus on creating more effective treatments and a healthier world for all.

Register now: https://ow.ly/q4bM50U1oE8

09/18/2024

Watch this exciting demonstration of micromanipulator technology.

Chemical Microscopy LLC will host a hands-on demonstration of the Micro Support Axis Pro benchtop micromanipulator on Wednesday, September 25, 2024, at 10:30

12/19/2023

https://www.wiley.com/en-us/Solving+Problems+with+Microscopy:+Real+life+Examples+in+Forensic,+Life+and+Chemical+Sciences-p-9781119788201

11/11/2022

Grateful for all who have served.

11/01/2022

Ritonavir Form III: Lightning strikes twice at the same time, 137 miles apart

Polymorph screening is a crucial step in the characterization and development of pharmaceuticals. The 1998 recall of ritonavir upon the unexpected appearance of the more stable Form II polymorph remains a notorious case of disappearing polymorphs as the presence of Form II inhibited the ability to g...

09/11/2022

07/06/2022

Read more about this groundbreaking technology developed in the early 80’s.

In 1981, Gerd Binnig and Heinrich Rohrer developed the scanning tunneling microscope. A microscope that transcended the limits of optical microscopes.

In optical microscopes the size of objects that can be observed is limited by the wavelength of light. The scanning tunneling microscope transcended this limit. The instrument is based on an extremely thin point that passes very close to a surface. A low electrical charge is positioned between the point and the surface, and through a quantum mechanical effect, the tunnel effect, a current arises that varies with the distance from the surface. The current is registered and allows the creation of an image in which objects as small as individual atoms can be distinguished.

Four years after revealing their new microscope, Binnig and Rohrer were awarded the 1986 Nobel Prize in Physics "for their design of the scanning tunneling microscope." They shared the award with Ernst Ruska.

Learn more about their research by reading their paper 'Surface Studies by Scanning Tunneling Microscopy' that was published on this day in 1982.

Read the publication: https://journals.aps.org/prl/pdf/10.1103/PhysRevLett.49.57