Jackson Immunoresearch

Jackson Immunoresearch Jackson ImmunoResearch Laboratories, Inc. specializes in the production and conjugation of affinity-purified secondary antibodies and purified immunoglobulins.

We have strict quality control standards giving our products an unparalleled reputation amoung the scientific community for reliability and reproducibility. Our range includes Affinity Purified Whole IgG, F(ab')2 Fragment and Monovalent Fab Fragment Antibodies with a multitude of species and conjugate options. There are in addition to our Flow Cytometry and Western Blot optimized antibodies, an ex

tensive range of blocking reagents and much more, providing a comprehensive solution for immunological procedures. Jackson ImmunoResearch Laboratories, Inc has been certified by BSI to ISO 9001:2008 under certificate FM 545248.

AIM2 drives inflammatory cell death and monkeypox pathogenesis.
06/05/2026

AIM2 drives inflammatory cell death and monkeypox pathogenesis.

Monkeypox, a zoonotic disease caused by the monkeypox virus (MPXV), has significant global public health implications. Inflammasomes serve as crucial components of the innate immune system, detecting pathogens and triggering cell death in infected cells to eliminate harmful agents. However, the prec...

CryoEM and computational modeling structural insights into the pH regulator NBCn1. Follow the link to access the full ar...
06/04/2026

CryoEM and computational modeling structural insights into the pH regulator NBCn1. Follow the link to access the full article

NBCn1 plays an important role as a base loader allowing breast cancer cells to survive in an acidic environment. Here, Wang et al report its near atomic structure and transport cycle involving minimal structural changes associated with an exceptionally high turnover rate, enabling efficient cellular...

A monoclonal antibody that inhibits the shedding of CD16a and CD16b and promotes antibody-dependent cellular cytotoxicit...
06/03/2026

A monoclonal antibody that inhibits the shedding of CD16a and CD16b and promotes antibody-dependent cellular cytotoxicity against tumors. Don't scroll without reading first at

CD16a triggers antibody-dependent cellular cytotoxicity but CD16a shedding dampens its anti-tumor activity. Here the authors develop a monoclonal antibody (F9H4) that prevents CD16a shedding, which synergizes with a tumor cell opsonizing antibody (cetuximab) to elicit natural killer cell-driven immu...

Eye‐Targeted A20 Gene Therapy Alleviates Ischemic Retinopathy by Reducing Pathologic Neovascularization, Gliosis, and Ne...
06/02/2026

Eye‐Targeted A20 Gene Therapy Alleviates Ischemic Retinopathy by Reducing Pathologic Neovascularization, Gliosis, and Neuronal Apoptosis. Click the link to learn more at

Intravitreal administration of anti‐VEGF therapies has been highly beneficial in treating ischemic proliferative retinopathies (PR). However, a quarter of patients do not benefit from these therapies due to primary or secondary non‐response and ...

Identification of a novel MIPEP splice variant with altered substrate-binding properties.
06/01/2026

Identification of a novel MIPEP splice variant with altered substrate-binding properties.

Mitochondrial intermediate peptidase (MIPEP) is a mitochondrial signal peptidase that removes N-terminal amino acids from mitochondrial matrix proteins. We have identified a novel Mipep splice variant that lacks exons 15 and 16, which we termed ...

Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period. Curious to...
05/31/2026

Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period. Curious to learn more? The following link has the full article

The melanocortin circuit of the hypothalamus is crucial for regulating energy balance, but the development of this circuit is incompletely understood. This study in mice shows that activity and vesicle release from oxytocin neurons during the first postnatal weak are critical for proper circuit deve...

Clinical performance of a dual-target SARS CoV-2 antibody assay using sera from Ghana. Learn more here with the followin...
05/30/2026

Clinical performance of a dual-target SARS CoV-2 antibody assay using sera from Ghana. Learn more here with the following article

During the pandemic, numerous serological tests for severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) have been developed. However, limited data

Citrullinated and Malondialdehyde–Acetaldehyde-Modified Fibrinogen Activates Macrophages and Promotes Coronary Endotheli...
05/29/2026

Citrullinated and Malondialdehyde–Acetaldehyde-Modified Fibrinogen Activates Macrophages and Promotes Coronary Endothelial Cell Inflammation.

Individuals with rheumatoid arthritis (RA) face increased cardiovascular mortality due to heart failure (HF) complications. Post-translational modifications, such as citrullination (CIT) and malondialdehyde–acetaldehyde (MAA) adduction, are implicated in RA pathogenesis. However, their role in RA-...

Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells.
05/28/2026

Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells.

Aims/hypothesis Residual pancreatic beta cells in type 1 diabetes show reduced insulin production but the mechanisms remain unclear. Beta cells undergo stress responses during type 1 diabetes, including endoplasmic reticulum (ER) stress and DNA damage-associated senescence, which may affect insulin....

Age-impaired remyelination is associated with dysregulated microglial transitions. Don't miss out on this fascinating ar...
05/27/2026

Age-impaired remyelination is associated with dysregulated microglial transitions. Don't miss out on this fascinating article

Microglial states throughout remyelination are incompletely understood. Here, the authors show that microglia form several states during the early stages of remyelination that coalesce into a partially resolved state that is dysregulated with age.

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